Cited by 174Lipid metabolism and disordersLipoproteins and Cardiovascular HealthDiabetes, Cardiovascular Risks, and Lipoproteins

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Remnant lipoproteins are related to intima-media thickness of the carotid artery independently of LDL cholesterol and plasma triglycerides

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Karpe, Fredrik, Boquist, Susanna, Tang, Rong, Bond, Gene M., de Faire, Ulf, Hamsten, Anders·2001·Journal of Lipid Research

DOI 10.1016/s0022-2275(20)32331-2

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Abstract

Remnants of triglyceride-rich lipoproteins (TRL) have been implicated in the early development of atherosclerosis. We tested this hypothesis by quantifying the plasma concentration of remnant-like particle cholesterol (RLP-C) in a cohort of healthy 50-year-old men in whom the common carotid artery intima-media thickness (CCA-IMT) was assessed by B-mode ultrasound as a surrogate marker for atherosclerosis. The subjects were given a fat-rich meal to study the generation of RLP-C during postprandial lipemia. Fasting plasma RLP-C and other major fasting plasma lipids and lipoproteins were determined twice, and the mean RLP-C concentration was strongly correlated with CCA-IMT (r = 0.32, P = 0.002). In addition, low density lipoprotein (LDL) cholesterol (r = 0.25, P = 0.01) and plasma triglycerides (r = 0.20, P = 0.05) were significantly related to CCA-IMT. Multivariate analyses showed a triglyceride-independent contribution of RLP-C to CCA-IMT. After fat intake, the median plasma RLP-C concentration was doubled after 3 h. The increase was strongly related to the postprandial generation of TRL apolipoprotein (apo)B-48, and large (S(f) 60;-400) TRL apoB-100. The association with CCA-IMT was somewhat stronger for the 3-h RLP-C level than for the fasting RLP-C concentration [r = 0.27, P < 0.01 (3 h) compared with r = 0.22, P < 0.05 (0 h)]. We conclude that the plasma concentration of RLP-C is related to CCA-IMT, independent of plasma triglycerides and LDL cholesterol, in a healthy middle-aged male population. - Karpe, F., S. Boquist, R. Tang, G. M. Bond, U. de Faire, and A. Hamsten. Remnant lipoproteins are related to intima-media thickness of the carotid artery independently of LDL cholesterol and plasma triglycerides. J. Lipid Res. 2001. 42: 17;-21.

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Authors: Karpe, F., Boquist, S., Tang, R., Bond, G. M., de Faire, U., & Hamsten, A.
Affiliations: Karolinska Institutet (SE)
Wake Forest University Health Sciences (US)
Corresponding author: Karpe, Fredrik
ORCID: Karpe, Fredrik
Tang, Rong
Hamsten, Anders
Venue: Journal of Lipid Research
Publisher: Elsevier BV
Published: 2001-01
Volume: 42
Issue: 1
Pages: 17-21
ISSN: 0022-2275 (ISSN-L)
DOI: 10.1016/s0022-2275(20)32331-2
OpenAlex: W1936800019
Cited by: 174
References: 14
Citations by year: 2026: 2 · 2025: 4 · 2024: 2 · 2023: 1 · 2022: 2 · 2021: 6 · 2020: 5 · 2019: 5 · 2018: 5 · 2017: 4 · 2016: 3 · 2015: 7 · 2014: 8 · 2013: 4 · 2012: 6
FWCI: 10.31
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 7191 d)
Locations: Journal of Lipid Research (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords: remnant-like particle cholesterol, remnant lipoproteins, triglyceride-rich lipoproteins, carotid intima-media thickness, atherosclerosis, LDL cholesterol, plasma triglycerides, postprandial lipemia, apolipoprotein B-48, apolipoprotein B-100, high-fat meal, middle-aged men
MeSH terms: Apolipoproteins, Arteriosclerosis, Carotid Arteries, Cholesterol, Fasting, Humans, Lipoproteins, Cholesterol, LDL, Male, Middle Aged, Triglycerides, Ultrasonography, Cohort Studies, Linear Models, Tunica Intima

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Remnant lipoproteins are related to intima-media thickness of the carotid artery independently of LDL cholesterol and plasma triglycerides

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