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Chylomicron remnant uptake is regulated by the expression and function of heparan sulfate proteoglycan in hepatocytes

Zeng, Bing-Ji, Mortimer, Bok-Cheng, Martins, Ian J., Seydel, Ulrich, Redgrave, Trevor G.·1998·Journal of Lipid Research
DOI 10.1016/s0022-2275(20)32571-2
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  • The genetic data presented here and previously, coupled with cell culture studies, argue for independent action of proteoglycans in the hepatic system.

    “Thus, we believe that the genetic data presented here and previously (9), coupled with numerous cell culture studies by other groups over the years (13–19, 21), argue for independent action of proteoglycans in the hepatic”

    From Syndecan-1 is the primary heparan sulfate proteoglycan mediating hepatic clearance of triglyceride-rich lipoproteins in mice (2009) · cites this paper as [19]

    The Discussion (page unavailable) reports residual remnant binding after LDL-receptor blockade and identifies an LDL-receptor-independent pathway, while the cell-culture results show that blocking syndecan also reduces binding. That supports a role for proteoglycans, but the paper does not establish their independent action in hepatic uptake; it also proposes that HSPGs may present remnants to other receptors for endocytosis. (LLM, conf=0.82)

    Experimental — accuracy not yet measured

  • Proteoglycans act independently in the hepatic clearance of triglyceride-rich remnants.

    “coupled with numerous cell culture studies by other groups over the years (13–19, 21), argue for independent action of proteoglycans in the hepatic clearance of triglyceride-rich remnants.”

    From Syndecan-1 is the primary heparan sulfate proteoglycan mediating hepatic clearance of triglyceride-rich lipoproteins in mice (2009) · cites this paper as [19]

    The Abstract reports that inhibiting heparan sulfate proteoglycans reduces remnant binding to HepG2 liver cells, supporting a role for proteoglycans. It does not establish that they act independently in hepatic clearance: the Discussion says binding depends on both proteoglycans and the LDL receptor and proposes that proteoglycans may present remnants to receptors for endocytosis. (LLM, conf=0.85)

    Experimental — accuracy not yet measured

  • Syndecan-1 can mediate binding and uptake of chylomicron remnants by HepG2 liver cells in vitro based on antisense and antibody inhibition experiments.

    “Syndecan-1 can also mediate binding and uptake of chylomicron remnants by HepG2 liver cells in vitro based on antisense and antibody inhibition experiments (19).”

    From Syndecan-1 is the primary heparan sulfate proteoglycan mediating hepatic clearance of triglyceride-rich lipoproteins in mice (2009) · cites this paper as [19]

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Research works printed but not linked: 46

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Metadata

Authors
Zeng, B.-J., Mortimer, B.-C., Martins, I. J., Seydel, U., & Redgrave, T. G.
Venue
Journal of Lipid Research
Publisher
Elsevier BV
Published
1998-04
Volume
39
Issue
4
Pages
845-860
ISSN
0022-2275
DOI
10.1016/s0022-2275(20)32571-2
Cited by
43
References
0
Language
en
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