The DOI matches its Crossref record; 90 of the 90 references it cites were found in a registry or an index.
Membrane transport of long-chain fatty acids: evidence for a facilitated process
Open accessAbstract
In mammalian cells, membrane uptake of long-chain fatty acids is mediated by two separate components; a passive component that is a linear function of the concentration of free fatty acid in the extracellular medium and a saturable component that exhibits the characteristics of a protein-facilitated process. This review summarizes the body of work that has accumulated related to the mechanism of fatty acid transport. Evidence in support of a facilitated uptake process is presented with relation to the different cell types or membrane systems where it was collected. The evidence includes saturation kinetics, competition between different substrates, and sensitivity to a variety of inhibitors. Recent knowledge related to membrane proteins thought to be implicated in the uptake process is reviewed. Factors that may modulate uptake or alter the relative contribution of passive versus facilitated components are briefly discussed. These include the molar ratio of fatty acid to its physiological carrier, plasma albumin and the metabolic or hormonal milieu.
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Cites
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Cited by
Unger, R. H. (2002) · Annual Review of Medicine · doi:10.1146/annurev.med.53.082901.104057 · Cited by 875
A Null Mutation in Murine CD36 Reveals an Important Role in Fatty Acid and Lipoprotein Metabolism
Febbraio, M., Abumrad, N. A., Hajjar, D. P., Sharma, K., Cheng, W., Pearce, S. F. A., & Silverstein, R. L. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.27.19055 · Cited by 769
Self-citationA novel mouse model of lipotoxic cardiomyopathy
Chiu, H.-C., Kovacs, A., Ford, D. A., Hsu, F.-F., Garcia, R., Herrero, P., Saffitz, J. E., & Schaffer, J. E. (2001) · Journal of Clinical Investigation · doi:10.1172/jci10947 · Cited by 760
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Self-citationBonen, A., Parolin, M. L., Steinberg, G. R., Calles‐Escandon, J., Tandon, N. N., Glatz, J. F. C., Luiken, J. J. F. P., Heigenhauser, G. J. F., & Dyck, D. J. (2004) · The FASEB Journal · doi:10.1096/fj.03-1065fje · Cited by 410
Metadata
- Authors
- Abumrad, N., Harmon, C., & Ibrahimi, A.
- Venue
- Journal of Lipid Research
- Publisher
- Elsevier BV
- Published
- 1998-12
- Volume
- 39
- Issue
- 12
- Pages
- 2309-2318
- ISSN
- 0022-2275 (ISSN-L)
- OpenAlex
- W2182965002
- Cited by
- 326
- References
- 90
- FWCI
- 10.55
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Abumrad, N., Harmon, C., & Ibrahimi, A. (1998). Membrane transport of long-chain fatty acids: evidence for a facilitated process. Journal of Lipid Research. https://doi.org/10.1016/s0022-2275(20)33310-1
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
