Lipotoxic diseases

Positional cloning of the mouse obese gene and its human homologue

Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature · doi:10.1038/372425a0 · Cited by 13,419 · see citing works

Weight-Reducing Effects of the Plasma Protein Encoded by the <i>obese</i> Gene

Halaas, J. L., Gajiwala, K. S., Maffei, M., Cohen, S. L., Chait, B. T., Rabinowitz, D., Lallone, R. L., Burley, S. K., & Friedman, J. M. (1995) · Science · doi:10.1126/science.7624777 · Cited by 4,451 · see citing works

Effects of the <i>obese</i> Gene Product on Body Weight Regulation in <i>ob</i> / <i>ob</i> Mice

Pelleymounter, M. A., Cullen, M. J., Baker, M. B., Hecht, R., Winters, D., Boone, T., & Collins, F. (1995) · Science · doi:10.1126/science.7624776 · Cited by 4,017 · see citing works

Recombinant Mouse OB Protein: Evidence for a Peripheral Signal Linking Adiposity and Central Neural Networks

Campfield, L. A., Smith, F. J., Guisez, Y., Devos, R., & Burn, P. (1995) · Science · doi:10.1126/science.7624778 · Cited by 3,243 · see citing works

Congenital leptin deficiency is associated with severe early-onset obesity in humans

Montague, C. T., Farooqi, I. S., Whitehead, J. P., Soos, M. A., Rau, H., Wareham, N. J., Sewter, C. P., Digby, J. E., Mohammed, S. N., Hurst, J. A., et al. (1997) · Nature · doi:10.1038/43185 · Cited by 2,936 · see citing works

Obesity and the regulation of energy balance

Spiegelman, B. M., & Flier, J. S. (2001) · Cell · doi:10.1016/s0092-8674(01)00240-9 · Cited by 2,398 · see citing works

A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction

Clément, K., Vaisse, C., Lahlou, N., Cabrol, S., Pelloux, V., Cassuto, D., Gourmelen, M., Dina, C., Chambaz, J., Lacorte, J.-M., et al. (1998) · Nature · doi:10.1038/32911 · Cited by 2,346 · see citing works

Abnormal splicing of the leptin receptor in diabetic mice

Lee, G.-H., Proenca, R., Montez, J. M., Carroll, K. M., Darvishzadeh, J. G., Lee, J. I., & Friedman, J. M. (1996) · Nature · doi:10.1038/379632a0 · Cited by 2,327 · see citing works

Programmed Cell Death Induced by Ceramide

Obeid, L. M., Linardic, C. M., Karolak, L. A., & Hannun, Y. A. (1993) · Science · doi:10.1126/science.8456305 · Cited by 1,794 · see citing works

Adipose Tissue as an Endocrine Organ

Ahima, R. S., & Flier, J. S. (2000) · Trends in Endocrinology &amp; Metabolism · doi:10.1016/s1043-2760(00)00301-5 · Cited by 1,608 · see citing works

The role of neuropeptide Y in the antiobesity action of the obese gene product

Stephens, T. W., Basinski, M., Bristow, P. K., Bue-Valleskey, J. M., Burgett, S. G., Craft, L., Hale, J., Hoffmann, J., Hsiung, H. M., Kriauciunas, A., et al. (1995) · Nature · doi:10.1038/377530a0 · Cited by 1,498 · see citing works

Differential expression and activation of a family of murine peroxisome proliferator-activated receptors.

Kliewer, S. A., FORMAN, B. M., Blumberg, B., Ong, E. S., Borgmeyer, U., Mangelsdorf, D. J., Umesono, K., & Evans, R. M. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.15.7355 · Cited by 1,400 · see citing works

Lipotoxic heart disease in obese rats: Implications for human obesity

Zhou, Y.-T., Grayburn, P., Karim, A., Shimabukuro, M., Higa, M., Baetens, D., Orci, L., & Unger, R. H. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.4.1784 · Cited by 1,265 · see citing works

Pathophysiology of insulin resistance in human disease

Reaven, G. M. (1995) · Physiological Reviews · doi:10.1152/physrev.1995.75.3.473 · Cited by 1,235 · see citing works

Fatty acid-induced β cell apoptosis: A link between obesity and diabetes

Shimabukuro, M., Zhou, Y.-T., Levi, M., & Unger, R. H. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.5.2498 · Cited by 1,142 · see citing works

Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice.

Vaisse, C., Halaas, J. L., Horvath, C. M., Darnell, J. E., Stoffel, M., & Friedman, J. M. (1996) · Nature Genetics · doi:10.1038/ng0996-95 · Cited by 1,086 · see citing works

The peroxisome proliferator activated receptors (PPARs) and their effects on lipid metabolism and adipocyte differentiation

Schoonjans, K., Staels, B., & Auwerx, J. H. (1996) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(96)00066-5 · Cited by 1,047 · see citing works

Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy

Shimomura, I., Hammer, R. E., Ikemoto, S., Brown, M. S., & Goldstein, J. L. (1999) · Nature · doi:10.1038/43448 · Cited by 1,038 · see citing works

Reduced Food Intake and Body Weight in Mice Treated with Fatty Acid Synthase Inhibitors

Loftus, T. M., Jaworsky, D. E., Frehywot, G. L., Townsend, C. A., Ronnett, G. V., Lane, M. D., & Kuhajda, F. P. (2000) · Science · doi:10.1126/science.288.5475.2379 · Cited by 1,004 · see citing works

Leptin: The Tale of an Obesity Gene

Caro, J. F., Sinha, M. K., Kolaczynski, J. W., Zhang, P. L., & Considine, R. V. (1996) · Diabetes · doi:10.2337/diab.45.11.1455 · Cited by 982 · see citing works

Fatty acids and retinoids control lipid metabolism through activation of peroxisome proliferator-activated receptor-retinoid X receptor heterodimers.

Keller, H., Dreyer, C., Medin, J. A., Mahfoudi, A., Ozato, K., & Wahli, W. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.6.2160 · Cited by 948 · see citing works

Role of Insulin Resistance in Human Disease (Syndrome X): An Expanded Definition

Reaven, G. M. (1993) · Annual Review of Medicine · doi:10.1146/annurev.me.44.020193.001005 · Cited by 908 · see citing works

Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl-CoA carboxylase 2

Abu-Elheiga, L., Matzuk, M. M., Abo-Hashema, K. A. H., & Wakil, S. J. (2001) · Science · doi:10.1126/science.1056843 · Cited by 903 · see citing works

Beta-cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: impairment in adipocyte-beta-cell relationships.

Lee, Y., Hirose, H., Ohneda, M., Johnson, J. H., McGarry, J., & Unger, R. H. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.23.10878 · Cited by 832 · see citing works

Leptin receptor missense mutation in the fatty Zucker rat

Phillips, M. S., Liu, Q., Hammond, H. A., Dugan, V., Hey, P. J., Caskey, C. T., & Hess, J. F. (1996) · Nature Genetics · doi:10.1038/ng0596-18 · Cited by 822 · see citing works

The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP

Ricquier, D., & Bouillaud, F. (2000) · Biochemical Journal · doi:10.1042/bj3450161 · Cited by 806 · see citing works

Obesity cardiomyopathy: pathophysiology and evolution of the clinical syndrome

Alpert, M. A. (2001) · The American Journal of the Medical Sciences · doi:10.1097/00000441-200104000-00003 · Cited by 795 · see citing works

A novel mouse model of lipotoxic cardiomyopathy

Chiu, H.-C., Kovács, A., Ford, D. A., Hsu, F., Garcia, R. A., Herrero, P., Saffitz, J. E., & Schaffer, J. E. (2001) · Journal of Clinical Investigation · doi:10.1172/jci10947 · Cited by 762 · see citing works

Tissue-specific overexpression of lipoprotein lipase causes tissue-specific insulin resistance

Kim, J. K., Fillmore, J. J., Chen, Y., Yu, C., Moore, I. K., Pypaert, M., Lutz, E. P., Kako, Y., Velez-Carrasco, W., Goldberg, I. J., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.121164498 · Cited by 753 · see citing works

A possible role for malonyl-CoA in the regulation of hepatic fatty acid oxidation and ketogenesis.

McGarry, J. D., Mannaerts, G. P., & Foster, D. W. (1977) · Journal of Clinical Investigation · doi:10.1172/jci108764 · Cited by 736 · see citing works

What if Minkowski Had Been Ageusic? An Alternative Angle on Diabetes

McGarry, J. D. (1992) · Science · doi:10.1126/science.1439783 · Cited by 657 · see citing works

Direct antidiabetic effect of leptin through triglyceride depletion of tissues

Shimabukuro, M., Koyama, K., Chen, G., Wang, M.-Y., Trieu, F., Lee, Y., Newgard, C. B., & Unger, R. H. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.9.4637 · Cited by 646 · see citing works

Lipotoxicity of beta-cells in obesity and in other causes of fatty acid spillover.

Unger, R. H., & Zhou, Y. (2001) · Diabetes · doi:10.2337/diabetes.50.2007.s118 · Cited by 476 · see citing works

A family of fatty acid transporters conserved from mycobacterium to man

Hirsch, D., Stahl, A., & Lodish, H. F. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.15.8625 · Cited by 454 · see citing works

Regulation of fatty acid homeostasis in cells: Novel role of leptin

Unger, R. H., Zhou, Y.-T., & Orci, L. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.5.2327 · Cited by 435 · see citing works

Diseases of liporegulation: new perspective on obesity and related disorders

Unger, R. H., & Orci, L. (2001) · The FASEB Journal · doi:10.1096/fj.00-0590 · Cited by 429 · see citing works

Lipoapoptosis in Beta-cells of Obese Prediabeticfa/fa Rats

Shimabukuro, M., Higa, M., Zhou, Y.-T., Wang, M.-Y., Newgard, C. B., & Unger, R. H. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.49.32487 · Cited by 394 · see citing works

Glucagon physiology and pathophysiology in the light of new advances

Unger, R. H. (1985) · Diabetologia · doi:10.1007/bf00281991 · Cited by 361 · see citing works

Membrane transport of long-chain fatty acids: evidence for a facilitated process

Abumrad, N. A., Harmon, C. M., & Ibrahimi, A. (1998) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)33310-1 · Cited by 326 · see citing works

The “Thrifty Genotype” in 19981

Neel, J. V. (2009) · Nutrition Reviews · doi:10.1111/j.1753-4887.1999.tb01782.x · Cited by 324 · see citing works

Fatty acid transport: difficult or easy?

Hamilton, J. A. (1998) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)33287-9 · Cited by 323 · see citing works

Generalized lipodystrophy, congenital and acquired (lipoatrophy)

Seip, M., & Trygstad, O. (1996) · Acta Paediatrica · doi:10.1111/j.1651-2227.1996.tb14262.x · Cited by 293 · see citing works

Role of nitric oxide in obesity-induced beta cell disease.

Shimabukuro, M., Ohneda, M., Lee, Y., & Unger, R. H. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119534 · Cited by 282 · see citing works

Effect of 5-Aminoimidazole-4-Carboxamide-1-β- d -Ribofuranoside Infusion on In Vivo Glucose and Lipid Metabolism in Lean and Obese Zucker Rats

Bergeron, R., Previs, S. F., Cline, G. W., Perret, P., Russell, R. R., Young, L. H., & Shulman, G. I. (2001) · Diabetes · doi:10.2337/diabetes.50.5.1076 · Cited by 280 · see citing works

Liporegulation in Diet-induced Obesity

Lee, Y., Wang, M.-Y., Kakuma, T., Wang, Z.-W., Babcock, E. E., McCorkle, K., Higa, M., Zhou, Y.-T., & Unger, R. H. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008553200 · Cited by 269 · see citing works

Pancreatic β-Cells in Obesity

Milburn, J. L., Hirose, H., Lee, Y. H., Nagasawa, Y., Ogawa, A., Ohneda, M., BeltrandelRio, H., Newgard, C. B., Johnson, J. H., & Unger, R. H. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.3.1295 · Cited by 269 · see citing works

Leptin, troglitazone, and the expression of sterol regulatory element binding proteins in liver and pancreatic islets

Kakuma, T., Lee, Y., Higa, M., Wang, Z.-W., Pan, W., Shimomura, I., & Unger, R. H. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.15.8536 · Cited by 261 · see citing works

Inhibition of fatty acid and cholesterol synthesis by stimulation of AMP‐activated protein kinase

Henin, N., Vincent, M. F., Gruber, H. E., & Berghe, G. (1995) · The FASEB Journal · doi:10.1096/fasebj.9.7.7737463 · Cited by 251 · see citing works

Troglitazone Lowers Islet Fat and Restores Beta Cell Function of Zucker Diabetic Fatty Rats

Shimabukuro, M., Zhou, Y.-T., Lee, Y., & Unger, R. H. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.6.3547 · Cited by 249 · see citing works

Obesity and the Heart

Alpert, M. A., & Hashimi, M. W. (1993) · The American Journal of the Medical Sciences · doi:10.1097/00000441-199308000-00011 · Cited by 245 · see citing works

Troglitazone prevents mitochondrial alterations, β cell destruction, and diabetes in obese prediabetic rats

Higa, M., Zhou, Y.-T., Ravazzola, M., Baetens, D., Orci, L., & Unger, R. H. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.20.11513 · Cited by 235 · see citing works

Protection against lipoapoptosis of β cells through leptin-dependent maintenance of Bcl-2 expression

Shimabukuro, M., Wang, M.-Y., Zhou, Y.-T., Newgard, C. B., & Unger, R. H. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.16.9558 · Cited by 212 · see citing works

Human and Murine Serine‐Palmitoyl‐CoA Transferase

Weiss, B., & Stoffel, W. (1997) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1997.00239.x · Cited by 205 · see citing works

Substitution at Codon 269 (Glutamine → Proline) of the Leptin Receptor (OB-R) cDNA Is the Only Mutation Found in the Zucker Fatty (fa/fa) Rat

Iida, M., Murakami, T., Ishida, K., Mizuno, A., Kuwajima, M., & Shima, K. (1996) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1996.1070 · Cited by 185 · see citing works

Lipodystrophy in patients naive to HIV protease inhibitors

Madge, S., Loes, S. K., Mercey, D., Johnson, M. A., & Weller, I. V. D. (1999) · AIDS · doi:10.1097/00002030-199904160-00020 · Cited by 184 · see citing works

Increased Lipogenic Capacity of the Islets of Obese Rats: A Role in the Pathogenesis of NIDDM

Lee, Y., Hiros, H., Zhou, Y.-T., Esser, V., McGarry, J., & Unger, R. H. (1997) · Diabetes · doi:10.2337/diab.46.3.408 · Cited by 184 · see citing works

Leptin plasma concentrations are dependent on body fat distribution in obese patients

Minocci, A., Savia, G., Lucantoni, R., Berselli, M. E., Tagliaferri, M., Calò, G., Petroni, M. L., Medici, C. D., Viberti, G., & Liuzzi, A. (2000) · International Journal of Obesity · doi:10.1038/sj.ijo.0801385 · Cited by 176 · see citing works

Role of peroxisome proliferator-activated receptor α in disease of pancreatic β cells

Zhou, Y.-T., Shimabukuro, M., Wang, M.-Y., Lee, Y., Higa, M., Milburn, J. L., Newgard, C. B., & Unger, R. H. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.15.8898 · Cited by 173 · see citing works

The cardiomyopathy of obesity

Alexander, J. K. (1985) · Progress in Cardiovascular Diseases · doi:10.1016/s0033-0620(85)80002-5 · Cited by 169 · see citing works

The role of leptin resistance in the lipid abnormalities of aging

WANG, Z.-W., Pan, W., Lee, Y., Kakuma, T., ZHOU, Y.-T., & Unger, R. H. (2001) · The FASEB Journal · doi:10.1096/fj.00-0310com · Cited by 146 · see citing works

Nucleoside reverse transcriptase inhibitor-induced mitochondrial toxicity as an etiology for lipodystrophy

Kakuda, T. N., Brundage, R. C., Anderson, P. L., & Fletcher, C. V. (1999) · AIDS · doi:10.1097/00002030-199911120-00019 · Cited by 144 · see citing works

Caloric restriction in obese pre-diabetic rats prevents beta-cell depletion, loss of beta-cell GLUT 2 and glucose incompetence

Ohneda, M., Inman, L. R., & Unger, R. H. (1995) · Diabetologia · doi:10.1007/bf00400091 · Cited by 110 · see citing works

OB-Rb gene transfer to leptin-resistant islets reverses diabetogenic phenotype

Wang, M.-Y., Koyama, K., Shimabukuro, M., Newgard, C. B., & Unger, R. H. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.2.714 · Cited by 102 · see citing works

Overexpression of leptin receptors in pancreatic islets of Zucker diabetic fatty rats restores GLUT-2, glucokinase, and glucose-stimulated insulin secretion

Wang, M.-Y., Koyama, K., Shimabukuro, M., Mangelsdorf, D. J., Newgard, C. B., & Unger, R. H. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.20.11921 · Cited by 98 · see citing works

Disruption of the Relationship between Fat Content and Leptin Levels with Aging in Humans

Møller, N. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.83.3.931 · Cited by 84 · see citing works

Adipose tissue as an endocrine organ

Ailhaud, G. (2000) · International Journal of Obesity · doi:10.1038/sj.ijo.0801267 · Cited by 79 · see citing works

Enhanced de novo lipogenesis in the leptin-unresponsive pancreatic islets of prediabetic Zucker diabetic fatty rats: role in the pathogenesis of lipotoxic diabetes.

Zhou, Y., Shimabukuro, M., Lee, Y., Koyama, K., Higa, M., Ferguson, T., & Unger, R. H. (1998) · Diabetes · doi:10.2337/diabetes.47.12.1904 · Cited by 75 · see citing works

Leptin physiology: a second look

Unger, R. H. (2000) · Regulatory Peptides · doi:10.1016/s0167-0115(00)00154-3 · Cited by 67 · see citing works

Cardiac findings in generalized lipodystrophy*

Bjørnstad, P., FOERSTER, A., & Ihlen, H. (1996) · Acta Paediatrica · doi:10.1111/j.1651-2227.1996.tb14264.x · Cited by 49 · see citing works

Increased lipogenic capacity of the islets of obese rats: a role in the pathogenesis of NIDDM

Lee, Y., Hirose, H., Zhou, Y. T., et al. (1997) · Diabetes · doi:10.2337/diabetes.46.3.408 · Cited by 47 · see citing works

Transient effects of long-term leptin supplementation in the prevention of diet-induced obesity in mice.

Surwit, R. S., Edwards, C. L., Murthy, S., & Petro, A. E. (2000) · Diabetes · doi:10.2337/diabetes.49.7.1203 · Cited by 40 · see citing works

Biochemical studies of the excitable membrane of Paramecium tetraurelia. VII. Sterols and other neutral lipids of cells and cilia.

Hennessey, T. M., Andrews, D. A., & Nelson, D. L. (1983) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)37962-1 · Cited by 30 · see citing works

Caloric restriction in obese pre-diabetic rats prevents beta-cell depletion, loss of beta-cell GLUT 2 and glucose incompetence

Ohneda, M., Inman, L. R., & Unger, R. H. (1995) · Diabetologia · doi:10.1007/s001250050267 · Cited by 9 · see citing works

AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism

Kahn, B. B., Alquier, T., Carling, D., & Hardie, D. G. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2004.12.003 · Cited by 2,799 · see citing works

Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans

Cinti, S., Mitchell, G., Barbatelli, G., Murano, I., Ceresi, E., Faloia, E., Wang, S., Fortier, M., Greenberg, A. S., & Obin, M. S. (2005) · Journal of Lipid Research · doi:10.1194/jlr.m500294-jlr200 · Cited by 2,529 · see citing works

Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes.

Guilherme, A., Virbasius, J. V., Puri, V., & Czech, M. P. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2391 · Cited by 2,292 · see citing works

Myocardial Fatty Acid Metabolism in Health and Disease

Lopaschuk, G. D., Ussher, J. R., Folmes, C. D. L., Jaswal, J. S., & Stanley, W. C. (2010) · Physiological Reviews · doi:10.1152/physrev.00015.2009 · Cited by 2,180 · see citing works

Myocardial Substrate Metabolism in the Normal and Failing Heart

Stanley, W. C., Recchia, F. A., & Lopaschuk, G. D. (2005) · Physiological Reviews · doi:10.1152/physrev.00006.2004 · Cited by 2,042 · see citing works

Oxygen, oxidative stress, hypoxia, and heart failure

Giordano, F. J. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24408 · Cited by 1,494 · see citing works

Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase

Haemmerle, G., Lass, A., Zimmermann, R., Gorkiewicz, G., Meyer, C., Rozman, J., Heldmaier, G., Maier, R., Theussl, C., Eder, S., et al. (2006) · Science · doi:10.1126/science.1123965 · Cited by 1,375 · see citing works

Overview of Epidemiology and Contribution of Obesity to Cardiovascular Disease

Bastien, M., Poirier, P., Lemieux, I., & Després, J.-P. (2014) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2013.10.016 · Cited by 1,125 · see citing works

Obesity Wars

Flier, J. S. (2004) · Cell · doi:10.1016/s0092-8674(03)01081-x · Cited by 1,105 · see citing works

Shotgun lipidomics: Electrospray ionization mass spectrometric analysis and quantitation of cellular lipidomes directly from crude extracts of biological samples

Han, X., & Gross, R. W. (2004) · Mass Spectrometry Reviews · doi:10.1002/mas.20023 · Cited by 1,111 · see citing works

Thematic review series: Glycerolipids. DGAT enzymes and triacylglycerol biosynthesis

Yen, C.-L. E., Stone, S. J., Koliwad, S., Harris, C., & Farese, R. V. (2008) · Journal of Lipid Research · doi:10.1194/jlr.r800018-jlr200 · Cited by 1,105 · see citing works

Fat tissue, aging, and cellular senescence

Tchkonia, T., Morbeck, D. E., Von Zglinicki, T., Van Deursen, J., Lustgarten, J., Scrable, H., Khosla, S., Jensen, M. D., & Kirkland, J. L. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2010.00608.x · Cited by 1,094 · see citing works

The Drosophila MicroRNA Mir-14 Suppresses Cell Death and Is Required for Normal Fat Metabolism

Xu, P., Vernooy, S. Y., Guo, M., & Hay, B. A. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00250-1 · Cited by 1,006 · see citing works

Adipose triglyceride lipase-mediated lipolysis of cellular fat stores is activated by CGI-58 and defective in Chanarin-Dorfman Syndrome

Lass, A., Zimmermann, R., Haemmerle, G., Riederer, M., Schoiswohl, G., Schweiger, M., Kienesberger, P. C., Bogner‐Strauß, J. G., Gorkiewicz, G., & Zechner, R. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.03.005 · Cited by 884 · see citing works

Insulin resistance: a metabolic pathway to chronic liver disease

Bugianesi, E., McCullough, A. J., & Marchesini, G. (2005) · Hepatology · doi:10.1002/hep.20920 · Cited by 900 · see citing works

Imaging of neutral lipids by oil red O for analyzing the metabolic status in health and disease

Mehlem, A., Hagberg, C. E., Muhl, L., Eriksson, U., & Falkevall, A. (2013) · Nature Protocols · doi:10.1038/nprot.2013.055 · Cited by 897 · see citing works

Adiponectin Expression From Human Adipose Tissue

Kern, P. A., Di Gregorio, G. B., Lu, T., Rassouli, N., & Ranganathan, G. (2003) · Diabetes · doi:10.2337/diabetes.52.7.1779 · Cited by 875 · see citing works

Free fatty acids promote hepatic lipotoxicity by stimulating TNF-α expression via a lysosomal pathway

Feldstein, A. E., Werneburg, N. W., Canbay, A. E., Guicciardi, M. E., Bronk, S. F., Rydzewski, R. M., Burgart, L. J., & Gores, G. J. (2004) · Hepatology · doi:10.1002/hep.20283 · Cited by 833 · see citing works

Adipokines and Insulin Resistance

Rabe, K., Lehrke, M., Parhofer, K. G., & Broedl, U. C. (2008) · Molecular Medicine · doi:10.2119/2008-00058.rabe · Cited by 814 · see citing works

Membrane Fatty Acid Transporters as Regulators of Lipid Metabolism: Implications for Metabolic Disease

Glatz, J. F. C., Luiken, J. J. F. P., & Bonen, A. (2010) · Physiological Reviews · doi:10.1152/physrev.00003.2009 · Cited by 757 · see citing works

Free Fatty Acids Induce JNK-dependent Hepatocyte Lipoapoptosis

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True

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