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Hepatic lipase facilitates the selective uptake of cholesteryl esters from remnant lipoproteins in apoE-deficient mice
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Hepatic lipase increases hepatic HDL-CE uptake.
“It has been shown that the enzyme hepatic lipase (HL) increases hepatic HDL-CE uptake (40-43).”
From The hepatic WASH complex is required for efficient plasma LDL and HDL cholesterol clearance (2019) · cites this paper as [40]
The passage indexed as Abstract (page unavailable) suggests that lipolysis may be required for HL-mediated enhanced selective uptake of HDL cholesteryl esters in apoE-deficient mice. It does not establish increased hepatic HDL-CE uptake: the measured increase in liver uptake was from VLDL cholesteryl ester, not HDL. (LLM, conf=0.85)
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Cited by
Sorted by citations
Cholesterol uptake in adrenal and gonadal tissues: the SR-BI and “selective” pathway connection
Azhar, S. (2003) · Frontiers in bioscience · doi:10.2741/1165 · Cited by 109
The hepatic WASH complex is required for efficient plasma LDL and HDL cholesterol clearance
Wijers, M., Zanoni, P., Liv, N., Vos, D. Y., Jäckstein, M. Y., Smit, M., Wilbrink, S., Wolters, J. C., van der Veen, Y. T., Huijkman, N., et al. (2019) · JCI Insight · doi:10.1172/jci.insight.126462 · Cited by 44
Metadata
- Authors
- Amar, M. J. A., Dugi, K. A., Haudenschild, C. C., Shamburek, R. D., Foger, B., Chase, M., Bensadoun, A., Hoyt, R. F., Brewer, H. B., & Santamarina-Fojo, S.
- Venue
- Journal of Lipid Research
- Publisher
- Elsevier BV
- Published
- 1998-12
- Volume
- 39
- Issue
- 12
- Pages
- 2436-2442
- ISSN
- 0022-2275
- Cited by
- 54
- References
- 1
- Language
- en
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