CoChat
Sign Up
Cited by 2,026

The DOI matches its Crossref record.

Identification of Scavenger Receptor SR-BI as a High Density Lipoprotein Receptor

Acton, Susan, Rigotti, Attilio, Landschulz, Katherine T., Xu, Shangzhe, Hobbs, Helen H., Krieger, Monty·1996·Science
DOI 10.1126/science.271.5248.518
Open this paper in CoChat — free account

Abstract

High density lipoprotein (HDL) and low density lipoprotein (LDL) are cholesterol transport particles whose plasma concentrations are directly (LDL) and inversely (HDL) correlated with risk for atherosclerosis. LDL catabolism involves cellular uptake and degradation of the entire particle by a well-characterized receptor. HDL, in contrast, selectively delivers its cholesterol, but not protein, to cells by unknown receptors. Here it is shown that the class B scavenger receptor SR-BI is an HDL receptor. SR-BI binds HDL with high affinity, is expressed primarily in liver and nonplacental steroidogenic tissues, and mediates selective cholesterol uptake by a mechanism distinct from the classic LDL receptor pathway.

Overview

Integrity signals

Registry

Crossref · 10.1126/science.271.5248.518

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

No references could be resolved yet.

Research works printed but not linked: 42

  1. ACTON L. S., EXPRESSION CLONING OF SR-BI, A CD36-RELATED CLASS-B SCAVENGER RECEPTOR, JOURNAL OF BIOLOGICAL CHEMISTRY 269, 21003 (1994). · DOI
  2. ANDERSEN M. J., KINETIC-PARAMETERS OF THE LIPOPROTEIN TRANSPORT-SYSTEMS IN THE ADRENAL-GLAND OF THE RAT DETERMINED INVIVO - COMPARISON OF LOW AND HIGH-DENSITY LIPOPROTEINS OF HUMAN AND RAT ORIGIN, JOURNAL OF BIOLOGICAL CHEMISTRY 256, 7362 (1981). · DOI · Paper page
  3. ARBEENY M. C., THE UPTAKE OF THE APOPROTEIN AND CHOLESTERYL ESTER OF HIGH-DENSITY-LIPOPROTEINS BY THE PERFUSED-RAT-LIVER, BIOCHIMICA ET BIOPHYSICA ACTA 917, 9 (1987). · DOI
  4. ASSRNAN G, METABOLIC MOL BASES: 2053 (1995).
  5. BRESLOW L. J., METABOLIC MOL BASES: 2031 (1995).
  6. BROWN S. M., RECENT PROGR HORMONE 35, 215 (1979).
  7. CALVO D, IDENTIFICATION, PRIMARY STRUCTURE, AND DISTRIBUTION OF CLA-1, A NOVEL MEMBER OF THE CD36/LIMPII GENE FAMILY, JOURNAL OF BIOLOGICAL CHEMISTRY 268, 18929 (1993). · DOI
  8. CHUNG H. B., SINGLE VERTICAL SPIN-DENSITY GRADIENT ULTRACENTRIFUGATION, METHODS IN ENZYMOLOGY 128, 181 (1986). · DOI
  9. CONVERSE A. C., LIPOPROTEIN ANAL PRA (1992). · DOI
  10. DELAMATRE G. J., EVIDENCE FOR EXTRALYSOSOMAL HYDROLYSIS OF HIGH-DENSITY-LIPOPROTEIN CHOLESTERYL ESTERS IN RAT HEPATOMA-CELLS (FU5AH) - A MODEL FOR DELIVERY OF HIGH-DENSITY-LIPOPROTEIN CHOLESTEROL, JOURNAL OF CELLULAR PHYSIOLOGY 146, 18 (1991). · DOI
  11. FIELDING J. C., MOLECULAR PHYSIOLOGY OF REVERSE CHOLESTEROL TRANSPORT, JOURNAL OF LIPID RESEARCH 36, 211 (1995). · DOI · Paper page
  12. GLASS C, UPTAKE OF HIGH-DENSITY LIPOPROTEIN-ASSOCIATED APOPROTEIN A-I AND CHOLESTEROL ESTERS BY 16 TISSUES OF THE RAT INVIVO AND BY ADRENAL-CELLS AND HEPATOCYTES INVITRO, JOURNAL OF BIOLOGICAL CHEMISTRY 260, 744 (1985). · DOI
  13. GLASS C, DISSOCIATION OF TISSUE UPTAKE OF CHOLESTEROL ESTER FROM THAT OF APOPROTEIN-A-I OF RAT PLASMA HIGH-DENSITY LIPOPROTEIN - SELECTIVE DELIVERY OF CHOLESTEROL ESTER TO LIVER, ADRENAL, AND GONAD, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES 80, 5435 (1983). · DOI
  14. GOLDSTEIN L. J., METABOLIC MOL BASES: 1981 (1995).
  15. GRUNDY M. S., CHOLESTEROL AND CORONARY HEART-DISEASE - A NEW ERA, JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION 256, 2849 (1986). · DOI
  16. GWYNNE T. J., THE ROLE OF LIPOPROTEINS IN STEROIDOGENESIS AND CHOLESTEROL-METABOLISM IN STEROIDOGENIC GLANDS, ENDOCRINE REVIEWS 3, 299 (1982). · DOI · Paper page
  17. GWYNNE T. J., RAT ADRENAL UPTAKE AND METABOLISM OF HIGH-DENSITY LIPOPROTEIN CHOLESTERYL ESTER, JOURNAL OF BIOLOGICAL CHEMISTRY 264, 8141 (1989). · DOI
  18. JACKLE S, DISSECTION OF COMPARTMENTS IN RAT HEPATOCYTES INVOLVED IN THE INTRACELLULAR TRAFFICKING OF HIGH-DENSITY-LIPOPROTEIN PARTICLES OR THEIR SELECTIVELY INTERNALIZED CHOLESTERYL ESTERS, HEPATOLOGY 17, 455 (1993).
  19. JOHNSON J. W., CHOLESTEROL TRANSPORT BETWEEN CELLS AND HIGH-DENSITY-LIPOPROTEINS, BIOCHIMICA ET BIOPHYSICA ACTA 1085, 273 (1991). · DOI
  20. JOKINEN V. E., REGULATION OF THE VERY-LOW-DENSITY LIPOPROTEIN RECEPTOR BY THYROID-HORMONE IN RAT SKELETAL-MUSCLE, JOURNAL OF BIOLOGICAL CHEMISTRY 269, 26411 (1994). · DOI
  21. KINGSLEY M. D., RECEPTOR-MEDIATED ENDOCYTOSIS OF LOW-DENSITY LIPOPROTEIN - SOMATIC-CELL MUTANTS DEFINE MULTIPLE GENES REQUIRED FOR EXPRESSION OF SURFACE-RECEPTOR ACTIVITY, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES 81, 5454 (1984). · DOI
  22. KNECHT P. T., A PLASMA-MEMBRANE POOL OF CHOLESTERYL ESTERS THAT MAY MEDIATE THE SELECTIVE UPTAKE OF CHOLESTERYL ESTERS FROM HIGH-DENSITY LIPOPROTEINS, BIOCHIMICA ET BIOPHYSICA ACTA 1002, 365 (1989). · DOI
  23. KOVANEN T. P., SEPARATE MECHANISMS FOR THE UPTAKE OF HIGH AND LOW-DENSITY LIPOPROTEINS BY MOUSE ADRENAL-GLAND INVIVO, JOURNAL OF BIOLOGICAL CHEMISTRY 254, 5498 (1979). · DOI · Paper page
  24. KRIEGER M, COMPLEMENTATION OF MUTATIONS IN THE LDL PATHWAY OF RECEPTOR-MEDIATED ENDOCYTOSIS BY CO-CULTIVATION OF LDL RECEPTOR-DEFECTIVE HAMSTER-CELL MUTANTS, CELL 33, 413 (1983). · DOI
  25. KRIEGER M, RECONSTITUTED LOW-DENSITY LIPOPROTEIN - VEHICLE FOR THE DELIVERY OF HYDROPHOBIC FLUORESCENT-PROBES TO CELLS, JOURNAL OF SUPRAMOLECULAR STRUCTURE 10, 467 (1979). · DOI
  26. LEITERSDORF E, THE ROLE OF APOLIPOPROTEINS OF HDL IN THE SELECTIVE UPTAKE OF CHOLESTERYL LINOLEYL ETHER BY CULTURED RAT AND BOVINE ADRENAL-CELLS, BIOCHIMICA ET BIOPHYSICA ACTA 878, 320 (1986). · DOI
  27. MACKINNON M, METABOLISM OF HIGH-DENSITY-LIPOPROTEINS BY THE PERFUSED RABBIT LIVER, JOURNAL OF BIOLOGICAL CHEMISTRY 261, 2548 (1986). · DOI
  28. MURPHY D. B., THE EFFECTS OF HYPOPHYSECTOMY AND ADMINISTRATION OF PITUITARY-HORMONES ON LUTEAL FUNCTION AND UPTAKE OF HIGH-DENSITY LIPOPROTEINS BY LUTEINIZED OVARIES AND ADRENALS OF THE RAT, ENDOCRINOLOGY 116, 1587 (1985). · DOI
  29. 10.1126/science.4035344 · DOI
  30. PIETERS N. M., IN-VITRO AND IN-VIVO EVIDENCE FOR THE ROLE OF HDL IN REVERSE CHOLESTEROL TRANSPORT, BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 1225, 125 (1994). · DOI
  31. PITAS E. R., ACETOACETYLATED LIPOPROTEINS USED TO DISTINGUISH FIBROBLASTS FROM MACROPHAGES INVITRO BY FLUORESCENCE MICROSCOPY, ARTERIOSCLEROSIS 1, 177 (1981). · DOI
  32. PITTMAN C. R., A NONENDOCYTOTIC MECHANISM FOR THE SELECTIVE UPTAKE OF HIGH-DENSITY LIPOPROTEIN-ASSOCIATED CHOLESTEROL ESTERS, JOURNAL OF BIOLOGICAL CHEMISTRY 262, 2443 (1987). · DOI
  33. REAVEN E, MORPHOLOGICAL EVIDENCE THAT HIGH-DENSITY LIPOPROTEINS ARE NOT INTERNALIZED BY STEROID-PRODUCING CELLS DURING INSITU ORGAN PERFUSION, JOURNAL OF CLINICAL INVESTIGATION 74, 1384 (1984). · DOI
  34. REAVEN E, CHOLESTEROL UPTAKE BY THE SELECTIVE PATHWAY OF OVARIAN GRANULOSA-CELLS - EARLY INTRACELLULAR EVENTS, JOURNAL OF LIPID RESEARCH 36, 1602 (1995). · DOI
  35. RIGOTTI A, THE CLASS-B SCAVENGER RECEPTORS SR-BI AND CD36 ARE RECEPTORS FOR ANIONIC PHOSPHOLIPIDS, JOURNAL OF BIOLOGICAL CHEMISTRY 270, 16221 (1995). · DOI
  36. RINNINGER F, A POOL OF REVERSIBLY CELL-ASSOCIATED CHOLESTERYL ESTERS INVOLVED IN THE SELECTIVE UPTAKE OF CHOLESTERYL ESTERS FROM HIGH-DENSITY-LIPOPROTEINS BY HEP G2 HEPATOMA-CELLS, BIOCHIMICA ET BIOPHYSICA ACTA 1166, 275 (1993). · DOI
  37. RINNINGER F, SELECTIVE UPTAKE OF HIGH-DENSITY LIPOPROTEIN-ASSOCIATED CHOLESTERYL ESTERS BY HUMAN HEPATOCYTES IN PRIMARY CULTURE, HEPATOLOGY 19, 1100 (1994). · DOI
  38. SCHOUTEN D, CHARACTERIZATION INVITRO OF INTERACTION OF HUMAN APOLIPOPROTEIN E-FREE HIGH-DENSITY-LIPOPROTEIN WITH HUMAN HEPATOCYTES, ARTERIOSCLEROSIS 10, 1127 (1990). · DOI
  39. SPARROW P. C., CHOLESTEROL ESTERS SELECTIVELY TAKEN UP FROM HIGH-DENSITY LIPOPROTEINS ARE HYDROLYZED EXTRALYSOSOMALLY, BIOCHIMICA ET BIOPHYSICA ACTA 1043, 203 (1990). · DOI
  40. STEIN Y, METABOLISM OF HDL-CHOLESTERYL ESTER IN THE RAT, STUDIED WITH A NON-HYDROLYZABLE ANALOG, CHOLESTERYL LINOLEYL ETHER, BIOCHIMICA ET BIOPHYSICA ACTA 752, 98 (1983). · DOI
  41. TALL R. A., PLASMA HIGH-DENSITY LIPOPROTEINS - METABOLISM AND RELATIONSHIP TO ATHEROGENESIS, JOURNAL OF CLINICAL INVESTIGATION 86, 379 (1990). · DOI
  42. WISHART R, UPTAKE AND METABOLISM OF HIGH-DENSITY LIPOPROTEINS BY CULTURED RABBIT HEPATOCYTES, BIOCHIMICA ET BIOPHYSICA ACTA 1044, 375 (1990). · DOI

Cited by

Sorted by citations

Metadata

Authors
Acton, S., Rigotti, A., Landschulz, K. T., Xu, S., Hobbs, H. H., & Krieger, M.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
1996-01-26
Volume
271
Issue
5248
Pages
518-520
ISSN
  • 0036-8075
  • 1095-9203
DOI
10.1126/science.271.5248.518
Cited by
2,026
References
0
Language
en

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review