The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Lipoprotein lipase and lipolysis: central roles in lipoprotein metabolism and atherogenesis
Open accessAbstract
Although it has been known for over 50 years that lipoprotein lipase (LPL) hydrolyzes triglyceride in chylomicrons, during the past half decade there has been a reinterest in the physiologic and pathophysiologic actions of this enzyme. In part, this has coincided with clinical studies implicating increased postprandial lipemia as a risk factor for atherosclerosis development. In addition, the recent creation of genetically altered mice with hypertriglyceridemia has focused the interest of geneticists and physiologists on the pathophysiology of triglyceride metabolism. As reviewed in this article, it is apparent that the lipolysis reaction is only partially understood. Several factors other than LPL are critical modulators of this process, in part, because the reaction requires the lipoproteins to interact with the arterial or capillary wall. Among the factors that affect this are the apolipoprotein composition of the particles, the size of the lipoproteins, and how LPL is displayed along the endothelial luminal surface. Zilversmit's observation that LPL activity is found in greater amounts in atherosclerotic than normal arteries has led to a large number of experiments linking LPL with atherogenesis. In medium and large arteries LPL is found on the luminal endothelial surface and in macrophage-rich areas within the plaque. LPL actions in both of these locations probably have major effects on the biology of the blood vessel. Possible atherogenic actions for this LPL based on in vitro experiments are reviewed.
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Triglycerides and Cardiovascular Disease: A Scientific Statement From the American Heart Association
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Inhibition of gastric inhibitory polypeptide signaling prevents obesity
Miyawaki, K., Yamada, Y., Ban, N., Ihara, Y., Tsukiyama, K., Zhou, H., Fujimoto, S., Oku, A., Tsuda, K., Toyokuni, S., et al. (2002) · Nature Medicine · doi:10.1038/nm727 · Cited by 963
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Rabenstein, D. L. (2002) · Natural Product Reports · doi:10.1039/b100916h · Cited by 870
Metadata
- Authors
- Goldberg, I. J.
- Venue
- Journal of Lipid Research
- Publisher
- Elsevier BV
- Published
- 1996-04
- Volume
- 37
- Issue
- 4
- Pages
- 693-707
- ISSN
- 0022-2275 (ISSN-L)
- OpenAlex
- W2117219849
- Cited by
- 1,010
- References
- 10
- FWCI
- 29.20
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Goldberg, I. J. (1996). Lipoprotein lipase and lipolysis: central roles in lipoprotein metabolism and atherogenesis. Journal of Lipid Research. https://doi.org/10.1016/s0022-2275(20)37569-6
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
