Postprandial hyperlipidemia and remnant lipoproteins.
Abstract
Improved methods for quantification of organ-specific contributions to postprandial hyperlipidemia indicate substantial increases in the concentration and altered properties of hepatogenous VLDL, in addition to accumulation of chylomicron remnants. Recent clinical studies support the hypothesis that small chylomicron remnants characterized by apolipoprotein (apo)B48 and VLDL remnants characterized by apolipoprotein B100 are atherogenic lipoproteins.
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Metabolic products of triglyceride-rich lipoproteins are atherogenic.
“In contrast, there is no doubt that metabolic products of triglyceride-rich lipoproteins are atherogenic (140 -142).”
From Evaluation and Treatment of Hypertriglyceridemia: An Endocrine Society Clinical Practice Guideline (2012) · cites this paper as [142]
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BackgroundResultChylomicron remnants are increased in the postprandial state in CD36 deficiency
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Measurement of postprandial remnant-like particles (RLPs) following a fat-loading test
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“containing triacylglycerol-rich lipoproteins constitute an overwhelming majority of the apo B-containing lipoproteins present in the postprandial state (Karpe et al. 19936, 1995; Schneeman et aE. 1993; Karpe & Hamsten, 1994; Havel, 1994).”
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“Key Words: CETP activity n chylomicrons n VLDL subspecies Several studies have provided data to support the hypothesisthat postprandial hypertriglyceridemia represents an independent risk factor for CAD.1–3 In patients with CAD, postprandial TG levels are higher and remain elevated over a longer period in comparison w…”
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“High-fat meals have been shown to increase glucose, insulin ( 11 ), and TG concentrations (11,12), impair (13‐18) or have minimal effect (19) on endothelial function; increase postprandial lipid hydroperoxides (biomarkers of oxidative stress) (20,21); and reduce the time needed to oxidize LDL particles (22).”
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MANAGEMENT OF SELECTED LIPID ABNORMALITIES
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Background
- Authors
- Havel, R. J.
- Affiliations
- University of California, San Francisco (US)
- Corresponding author
- Havel, Richard J.
- Venue
- Current Opinion in Lipidology
- Published
- 1994-04
- Volume
- 5
- Issue
- 2
- Pages
- 102-109
- ISSN
- 0957-9672 (ISSN-L)
- OpenAlex
- W2046776466
- Cited by
- 209
- References
- 0
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 1 · 2023: 6 · 2022: 15 · 2021: 1 · 2020: 5 · 2019: 1 · 2018: 2 · 2017: 5 · 2016: 7 · 2015: 4 · 2014: 3 · 2013: 6 · 2012: 2
- FWCI
- 10.75
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Lipidology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Keywords
- postprandial lipemia, remnant lipoproteins, chylomicron remnants, VLDL remnants, apolipoprotein B-48, apolipoprotein B-100, atherogenic lipoproteins, hepatic VLDL secretion
- MeSH terms
- Apolipoproteins B, Chylomicrons, Coronary Disease, Food, Humans, Hyperlipidemias, Lipoproteins, Lipoproteins, VLDL, Triglycerides, Apolipoprotein B-48, Apolipoprotein B-100
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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