The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Simultaneous determination of tissue tocopherols, tocotrienols, ubiquinols, and ubiquinones
Open accessAbstract
A tissue-specific distribution of the various vitamin E forms, tocotrienols and tocopherols, has been found, suggesting that these forms have unique roles in cellular functions. A sensitive procedure is described for the simultaneous determination of individual tocopherols, tocotrienols, ubiquinols, and ubiquinones using gradient high pressure liquid chromatography (HPLC) and electrochemical detection for vitamin E homologues and ubiquinols, and in-line UV detection for ubiquinones. Using this method, the lipophilic antioxidant complement of a variety of hairless mouse tissues was analyzed. Of the vitamin E forms, brain contained virtually only alpha-tocopherol (5.4 +/- 0.1 nmol/g; 99.8%) and no detectable tocotrienols were found. By contrast, skin contained nearly 15% tocotrienols and 1% gamma-tocopherol. In other tissues, the alpha-tocopherol content was higher (20 nmol/g), while each of the other forms represented about 1% of the total (gamma-tocopherol 0.2 to 0.4 nmol/g, alpha-tocotrienol 0.1, gamma-tocotrienol 0.2). Ubiquinol-9 concentrations were highest in kidney (81 nmol/g) and in liver (42 nmol/g), while the highest ubiquinone-9 concentrations were found in kidney (301 +/- 123 nmol/g) and heart (244 +/- 22 nmol/g). Liver contained nearly identical concentrations of each of the redox couple (ubiquinol-9 (41 +/- 16 nmol/g) and ubiquinone-9 (46 +/- 18 nmol/g). The unique distribution of these various antioxidants in the tissues measured suggests their distribution may be dependent upon selective mechanisms for maintaining antioxidant defenses in each tissue.
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Cites
Biochemical, physiological and medical aspects of ubiquinone function
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Stocker, R., Bowry, V. W., & Frei, B. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.5.1646 · Cited by 793
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Self-citationUbiquinol-10 is an effective lipid-soluble antioxidant at physiological concentrations.
Frei, B., Kim, M. C., & Ames, B. N. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.12.4879 · Cited by 620
Isolation of a quinone from beef heart mitochondria
Crane, F. L., Hatefi, Y., Lester, R. L., & Widmer, C. (1957) · Biochimica et Biophysica Acta · doi:10.1016/0006-3002(57)90457-2 · Cited by 587
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Vitamin E in Humans: Demand and Delivery
Traber, M. G., & Sies, H. (1996) · Annual Review of Nutrition · doi:10.1146/annurev.nu.16.070196.001541 · Cited by 502
Self-citationLang, J. K., Gohil, K., & Packer, L. (1986) · Analytical Biochemistry · doi:10.1016/0003-2697(86)90203-4 · Cited by 491
Self-citationParker, R. A., Pearce, B. C., Clark, R. W., Gordon, D. A., & Wright, J. J. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)82115-9 · Cited by 436
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Cited by
Halliwell, B. (2001) · Drugs & Aging · doi:10.2165/00002512-200118090-00004 · Cited by 1,502
Cutaneous photodamage, oxidative stress, and topical antioxidant protection
Pinnell, S. R. (2003) · Journal of the American Academy of Dermatology · doi:10.1067/mjd.2003.16 · Cited by 544
Molecular Aspects of α-Tocotrienol Antioxidant Action and Cell Signalling
Packer, L., Weber, S. U., & Rimbach, G. (2001) · The Journal of Nutrition · doi:10.1093/jn/131.2.369s · Cited by 520
Self-citationBramley, P., Elmadfa, I., Kafatos, A., Kelly, F., Manios, Y., Roxborough, H., Schuch, W., Sheehy, P., & Wagner, K.-H. (2000) · Journal of the Science of Food and Agriculture · doi:10.1002/(sici)1097-0010(20000515)80:7<913::aid-jsfa600>3.0.co;2-3 · Cited by 503
Vitamin E: non-antioxidant roles
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Metadata
- Authors
- Podda, M., Weber, C., Traber, M. G., & Packer, L.
- Venue
- Journal of Lipid Research
- Publisher
- Elsevier BV
- Published
- 1996-04
- Volume
- 37
- Issue
- 4
- Pages
- 893-901
- ISSN
- 0022-2275 (ISSN-L)
- OpenAlex
- W2151820614
- Cited by
- 344
- References
- 34
- FWCI
- 3.11
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Podda, M., Weber, C., Traber, M. G., & Packer, L. (1996). Simultaneous determination of tissue tocopherols, tocotrienols, ubiquinols, and ubiquinones. Journal of Lipid Research. https://doi.org/10.1016/s0022-2275(20)37587-8
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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