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Cited by 34

The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.

Presence of dolichol and its derivatives in human blood.

Elmberger, P G, Engfeldt, P, Dallner, G·1988·Journal of Lipid Research

Abstract

Optimal conditions for the quantitative estimation of dolichol in human plasma were determined. Because of the large amounts of other lipids present in the blood, the extraction procedure, the procedure for hydrolysis, and the HPLC procedure are of decisive importance. Human plasma contains dolichol, dolichyl esters, and dolichyl phosphate at concentrations of 41, 102, and 55 ng/g, respectively. These polyisoprenoid lipids are associated with the high density lipoprotein fraction. The relative amounts and compositions of dolichyl esters in the plasma are similar to those observed in isolated human liver microsomes and Golgi vesicles. Sixty percent of the fatty acids present are saturated and almost no long-chain polyunsaturated components are present. There is no correlation between blood dolichol content and weight, sex, dietary state, or plasma cholesterol level, but there is an inverse relationship to plasma triglyceride content. A linear increase in the total plasma dolichol content with increasing age was found. In a few pathological conditions where the level of blood cholesterol was increased, the total blood dolichol content was not affected. Apparently, dolichol is a stable lipid component of human high density lipoprotein.

Overview

Integrity signals

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Crossref · 10.1016/s0022-2275(20)38414-5

Cites

58 of 58 references verified0 citation errors · 0 not checkable

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Citations

Cites

Research works printed but not linked: 3

  1. Wolfe, 1987, Dolichols, lysosomal membrane turnover and relationships to the accumulation of ceroid and lipofuscin in inherited diseases, Alzheimer's disease and aging, Chem. Scr., 27, 79
  2. Pullarkat, 1987, Dolichols and phosphodolichols in aging and in neurological disorders, Chem. Scr., 27, 85
  3. Haltia, 1987, Infantile neuronal ceroid-lipofuscinosis: an inherited disorder with disturbed dolichol metabolism, Chem. Scr., 27, 89

Cited by

See all 34

Metadata

Authors
Elmberger, P. G., Engfeldt, P., & Dallner, G.
Venue
Journal of Lipid Research
Publisher
Elsevier BV
Published
1988-12
Volume
29
Issue
12
Pages
1651-1662
ISSN
0022-2275
Cited by
34
References
58
Language
en

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.