The DOI matches its Crossref record.
The citrate cleavage pathway and lipogenesis in rat adipose tissue: replenishment of oxaloacetate
Open accessAbstract
Fatty acid synthesis via the citrate cleavage pathway requires the continual replenishment of oxaloacetate within the mitochondria, probably by carboxylation of pyruvate. Malic enzyme, although present in adipose tissue, is completely localized in the cytoplasm and has insufficient activity to support lipogenesis. Pyruvate carboxylase was found to be active in both the mitochondria and cytoplasm of epididymal adipose tissue cells; it was dependent on both ATP and biotin. Alteractions in dietary conditions induced no significant changes in mitochondrial pyruvate carboxylase activity, but the soluble activity was depressed in fat-fed animals. The possible importance of the soluble activity in lipogenesis lies in its participation in a soluble malate transhydrogenation cycle with NAD malate dehydrogenase and malic enzyme, whereby a continual supply of NADPH is produced. Consequently, the pyruvate carboxylase in adipose tissue both generates mitochondrial oxaloacetate for the citrate cleavage pathway and supplies soluble NADPH for the conversion of acetyl-CoA to fatty acid.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Structure, mechanism and regulation of pyruvate carboxylase
Jitrapakdee, S., St Maurice, M., Rayment, I., Cleland, W. W., Wallace, J. C., & Attwood, P. V. (2008) · Biochemical Journal · doi:10.1042/bj20080709 · Cited by 451
Phosphoenolpyruvate carboxykinase and pyruvate carboxylase in developing rat liver
Ballard, F., & Hanson, R. (1967) · Biochemical Journal · doi:10.1042/bj1040866 · Cited by 408
Self-citationHanson, R. W., & Ballard, F. J. (1967) · Biochemical Journal · doi:10.1042/bj1050529 · Cited by 297
Self-citationAnaplerotic roles of pyruvate carboxylase in mammalian tissues
Jitrapakdee, S., Vidal-Puig, A., & Wallace, J. C. (2006) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-005-5410-y · Cited by 149
Metadata
- Authors
- Ballard, F. J., & Hanson, R. W.
- Venue
- Journal of Lipid Research
- Publisher
- Elsevier BV
- Published
- 1967-03
- Volume
- 8
- Issue
- 2
- Pages
- 73-79
- ISSN
- 0022-2275 (ISSN-L)
- OpenAlex
- W2098544099
- Cited by
- 164
- References
- 0
- FWCI
- 8.03
- Type
- journal article
- Language
- en
- Open access
- hybrid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: The citrate cleavage pathway and lipogenesis in rat adipose tissue: replenishment of oxaloacetate. https://app.cochat.ai/papers/10.1016/s0022-2275(20)38917-3
- The paper
- Ballard, F. J., & Hanson, R. W. (1967). The citrate cleavage pathway and lipogenesis in rat adipose tissue: replenishment of oxaloacetate. Journal of Lipid Research. https://doi.org/10.1016/s0022-2275(20)38917-3
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
