Anaplerotic roles of pyruvate carboxylase in mammalian tissues
Open accessAbstract
Pyruvate carboxylase (PC) catalyzes the ATP-dependent carboxylation of pyruvate to oxaloacetate. PC serves an anaplerotic role for the tricarboxylic acid cycle, when intermediates are removed for different biosynthetic purposes. In liver and kidney, PC provides oxaloacetate for gluconeogenesis. In adipocytes PC is involved in de novo fatty acid synthesis and glyceroneogenesis, and is regulated by the peroxisome proliferator-activated receptor-gamma, suggesting that PC is involved in the metabolic switch controlling fuel partitioning toward lipogenesis. In islets, PC is necessary for glucose-induced insulin secretion by providing oxaloacetate to form malate that participates in the 'pyruvate/malate cycle' to shuttle 3C or 4C between mitochondria and cytoplasm. Hyperglycemia and hyperlipidemia impair this cycle and affect glucose-stimulated insulin release. In astrocytes, PC is important for de novo synthesis of glutamate, an important excitatory neurotransmitter supplied to neurons. Transcriptional studies of the PC gene pinpoint some transcription factors that determine tissue-specific expression.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
PC-mediated alternative anaplerosis is important in liver cancers and glioblastoma for maintaining biosynthesis and redox homeostasis.
“This PC-mediated alternative anaplerosis is considered important in specific types of cancers, including liver cancers and glioblastoma, for maintaining biosynthesis and redox homeostasis154–156.”
From Glutamine reliance in cell metabolism (2020) · cites this paper as [154]
Cites
Brown Adipose Tissue: Function and Physiological Significance
CANNON, B., & NEDERGAARD, J. (2004) · Physiological Reviews · doi:10.1152/physrev.00015.2003 · Cited by 6,433 · see citing works
Insulin signalling and the regulation of glucose and lipid metabolism
Saltiel, A. R., & Kahn, C. R. (2001) · Nature · doi:10.1038/414799a · Cited by 5,326 · see citing works
Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
Cross, D. A. E., Alessi, D. R., Cohen, P., Andjelkovich, M., & Hemmings, B. A. (1995) · Nature · doi:10.1038/378785a0 · Cited by 5,244 · see citing works
Transcriptional regulation by the phosphorylation-dependent factor CREB
Mayr, B., & Montminy, M. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35085068 · Cited by 2,587 · see citing works
CREB regulates hepatic gluconeogenesis through the coactivator PGC-1
Herzig, S., Long, F., Jhala, U. S., Hedrick, S., Quinn, R., Bauer, A., Rudolph, D., Schutz, G., Yoon, C., Puigserver, P., et al. (2001) · Nature · doi:10.1038/35093131 · Cited by 1,440 · see citing works
Molecular Regulation of Adipogenesis
Rosen, E. D., & Spiegelman, B. M. (2000) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.16.1.145 · Cited by 1,287 · see citing works
Fatty acid-induced β cell apoptosis: A link between obesity and diabetes
Shimabukuro, M., Zhou, Y.-T., Levi, M., & Unger, R. H. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.5.2498 · Cited by 1,142 · see citing works
Glucose induces closure of single potassium channels in isolated rat pancreatic β-cells
Ashcroft, F. M., Harrison, D. E., & Ashcroft, S. J. H. (1984) · Nature · doi:10.1038/312446a0 · Cited by 1,113 · see citing works
Biochemistry and physiology of brain ammonia.
Cooper, A. J. L., & Plum, F. (1987) · Physiological Reviews · doi:10.1152/physrev.1987.67.2.440 · Cited by 850 · see citing works
Poitout, V., & Robertson, R. P. (2002) · Endocrinology · doi:10.1210/endo.143.2.8623 · Cited by 743 · see citing works
A Lesson in Metabolic Regulation Inspired by the Glucokinase Glucose Sensor Paradigm
Matschinsky, F. (1996) · Diabetes · doi:10.2337/diab.45.2.223 · Cited by 721 · see citing works
Impey, S., McCorkle, S., Cha‐Molstad, H., Dwyer, J. M., Yochum, G. S., Boss, J. M., McWeeney, S. K., Dunn, J. J., Mandel, G., & Goodman, R. H. (2004) · Cell · doi:10.1016/j.cell.2004.10.032 · Cited by 695 · see citing works
Mitochondrial remodeling in adipose tissue associated with obesity and treatment with rosiglitazone.
Wilson-Fritch, L., Nicoloro, S., Chouinard, M., Lazar, M. A., Chui, P. C., Leszyk, J., Straubhaar, J., Czech, M. P., & Corvera, S. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21752 · Cited by 616 · see citing works
Induction of fatty acid synthetase synthesis in differentiating 3T3-L1 preadipocytes.
Student, A. K., Hsu, R. Y., & Lane, M. D. (1980) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)85559-x · Cited by 590 · see citing works
METABOLIC COUPLING FACTORS IN PANCREATIC β-CELL SIGNAL TRANSDUCTION
Newgard, C. B., & McGarry, J. (1995) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.64.070195.003353 · Cited by 531 · see citing works
Glyceroneogenesis and the triglyceride/fatty acid cycle
Reshef, L., Olswang, Y., Cassuto, H., Blum, B., Croniger, C. M., Kalhan, S. C., Tilghman, S. M., & Hanson, R. W. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.r300017200 · Cited by 475 · see citing works
Shank, R. P., Bennett, G. S., Freytag, S. O., & Campbell, G. L. (1985) · Brain Research · doi:10.1016/0006-8993(85)90552-9 · Cited by 471 · see citing works
Astrocytic control of glutamatergic activity: astrocytes as stars of the show
Hertz, L., & Zielke, H. R. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2004.10.008 · Cited by 470 · see citing works
Anthonsen, M. W., Rönnstrand, L., Wernstedt, C., Degerman, E., & Holm, C. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.1.215 · Cited by 468 · see citing works
Metabolic Fate of Glucose in Purified Islet Cells
Schuit, F., De Vos, A., Farfari, S., Moens, K., Pipeleers, D., Brun, T., & Prentki, M. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.30.18572 · Cited by 421 · see citing works
Carbohydrate response element binding protein directly promotes lipogenic enzyme gene transcription
Ishii, S., Iizuka, K., Miller, B. C., & Uyeda, K. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0405238101 · Cited by 416 · see citing works
Pyruvate Carboxylase Activity in Primary Cultures of Astrocytes and Neurons
Yu, A. C., Drejer, J., Hertz, L., & Schousboe, A. (1983) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1983.tb00849.x · Cited by 406 · see citing works
Lipoapoptosis in Beta-cells of Obese Prediabeticfa/fa Rats
Shimabukuro, M., Higa, M., Zhou, Y.-T., Wang, M.-Y., Newgard, C. B., & Unger, R. H. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.49.32487 · Cited by 394 · see citing works
Lang, J. (1999) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.1999.00043.x · Cited by 347 · see citing works
Induction of lipogenesis during differentiation in a "preadipocyte" cell line.
Mackall, J. C., Student, A. K., Polakis, S. E., & Lane, M. D. (1976) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)81883-3 · Cited by 316 · see citing works
Feasibility of a Mitochondrial Pyruvate Malate Shuttle in Pancreatic Islets
MacDonald, M. J. (1995) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)94588-6 · Cited by 274 · see citing works
Ivarsson, R., Quintens, R., Dejonghe, S., Tsukamoto, K., in ’t Veld, P., Renström, E., & Schuit, F. C. (2005) · Diabetes · doi:10.2337/diabetes.54.7.2132 · Cited by 265 · see citing works
Lu, D., Mulder, H., Zhao, P., Burgess, S. C., Jensen, M. V., Kamzolova, S. V., Newgard, C. B., & Sherry, A. D. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.052005699 · Cited by 265 · see citing works
Farfari, S., Schulz, V., Corkey, B. E., & Prentki, M. (2000) · Diabetes · doi:10.2337/diabetes.49.5.718 · Cited by 263 · see citing works
MacDonald, M. J., Fahien, L. A., Brown, L. J., Hasan, N. M., Buss, J. D., & Kendrick, M. A. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00218.2004 · Cited by 244 · see citing works
Structure, function and regulation of pyruvate carboxylase
Jitrapakdee, S., & Wallace, J. C. (1999) · Biochemical Journal · doi:10.1042/bj3400001 · Cited by 244 · see citing works
Self-citationBusch, A. K., Cordery, D. V., Denyer, G. S., & Biden, T. J. (2002) · Diabetes · doi:10.2337/diabetes.51.4.977 · Cited by 184 · see citing works
β-Cell Adaptation to Insulin Resistance
Liu, Y. Q., Jetton, T. L., & Leahy, J. L. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m207157200 · Cited by 166 · see citing works
The citrate cleavage pathway and lipogenesis in rat adipose tissue: replenishment of oxaloacetate
Ballard, F. J., & Hanson, R. W. (1967) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38917-3 · Cited by 166 · see citing works
Critical Reduction in β-Cell Mass Results in Two Distinct Outcomes over Time
Laybutt, D. R., Glandt, M., Xu, G., Ahn, Y. B., Trivedi, N., Bonner‐Weir, S., & Weir, G. C. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210581200 · Cited by 156 · see citing works
Evidence for an Anaplerotic/Malonyl-CoA Pathway in Pancreatic β-Cell Nutrient Signaling
Brun, T., Roche, E., Assimacopoulos-Jeannet, F., Corkey, B., Kim, K.-H., & Prentki, M. (1996) · Diabetes · doi:10.2337/diab.45.2.190 · Cited by 150 · see citing works
Roche, E., Farfari, S., Witters, L. A., Assimacopoulos‐Jeannet, F., Thumelin, S., Brun, T., Corkey, B. E., Saha, A. K., & Prentki, M. (1998) · Diabetes · doi:10.2337/diabetes.47.7.1086 · Cited by 145 · see citing works
Boucher, A., Lu, D., Burgess, S. C., Telemaque-Potts, S., Jensen, M. V., Mulder, H., Wang, M.-Y., Unger, R. H., Sherry, A. D., & Newgard, C. B. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m401167200 · Cited by 136 · see citing works
Caloric restriction increases gluconeogenic and transaminase enzyme activities in mouse liver
Hagopian, K. (2003) · Experimental Gerontology · doi:10.1016/s0531-5565(02)00202-4 · Cited by 135 · see citing works
Efanov, A. M., Sewing, S., Bokvist, K. B., & Gromada, J. (2004) · Diabetes · doi:10.2337/diabetes.53.suppl_3.s75 · Cited by 135 · see citing works
Cesar, M., & Hamprecht, B. (1995) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1995.64052312.x · Cited by 118 · see citing works
Mackall, J. C., & Lane, M. D. (1977) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(77)91171-8 · Cited by 109 · see citing works
Hertz, L. (2000) · Neurochemistry International · doi:10.1016/s0197-0186(00)00012-7 · Cited by 109 · see citing works
Gamberino, W. C., Berkich, D. A., Lynch, C. J., Xu, B., & LaNoue, K. F. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.69062312.x · Cited by 107 · see citing works
Miller, K. E., Richards, B. A., & Kriebel, R. M. (2002) · Brain Research · doi:10.1016/s0006-8993(02)02802-0 · Cited by 98 · see citing works
Zhou, Y.-P., Berggren, P., & Grill, V. (1996) · Diabetes · doi:10.2337/diab.45.5.580 · Cited by 90 · see citing works
Quantifying the Carboxylation of Pyruvate in Pancreatic Islets
Khan, A., Ling, Z. C., & Landau, B. R. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.5.2539 · Cited by 86 · see citing works
MacDonald, M. J. (1993) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1993.1413 · Cited by 84 · see citing works
MacDonald, M. J., Efendić, S., & Östenson, C. (1996) · Diabetes · doi:10.2337/diab.45.7.886 · Cited by 82 · see citing works
Jitrapakdee, S., Slawik, M., Medina‐Gómez, G., Campbell, M., Wallace, J. C., Sethi, J. K., O’Rahilly, S., & Vidal‐Puig, A. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m503836200 · Cited by 81 · see citing works
Self-citationCarbon Dioxide Fixation in Neuronal and Astroglial Cells in Culture
Kaufman, E. E., & Driscoll, B. F. (1992) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1992.tb09304.x · Cited by 78 · see citing works
In vitro and in vivo suppression of gluconeogenesis by inhibition of pyruvate carboxylase
Bahl, J. J., Matsuda, M., DeFronzo, R. A., & BRESSLER, R. C. (1997) · Biochemical Pharmacology · doi:10.1016/s0006-2952(96)00660-0 · Cited by 77 · see citing works
Gauthier, B. R., Brun, T., Sarret, E. J., Ishihara, H., Schaad, O., Descombes, P., & Wollheim, C. B. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m405030200 · Cited by 72 · see citing works
Disorders of pyruvate carboxylase and the pyruvate dehydrogenase complex
Robinson, B. H., MacKay, N., Chun, K., & Ling, M. (1996) · Journal of Inherited Metabolic Disease · doi:10.1007/bf01799106 · Cited by 72 · see citing works
Lack of Glyconeogenesis in Pancreatic Islets: Expression of Gluconeogenic Enzyme Genes in Islets
MacDonald, M., McKenzie, D., Walker, T. M., & Kaysen, J. H. (1992) · Hormone and Metabolic Research · doi:10.1055/s-2007-1003284 · Cited by 68 · see citing works
The Succinate Mechanism of Insulin Release
Fahien, L. A., & MacDonald, M. J. (2002) · Diabetes · doi:10.2337/diabetes.51.9.2669 · Cited by 66 · see citing works
Stimulus/Secretion Coupling Factors in Glucose-Stimulated Insulin Secretion
Newgard, C. B., Lu, D., Jensen, M. V., Schisler, J. C., Boucher, A., Burgess, S. C., & Sherry, A. D. (2002) · Diabetes · doi:10.2337/diabetes.51.2007.s389 · Cited by 66 · see citing works
MacDonald, M. J., Tang, J., & Polonsky, K. S. (1996) · Diabetes · doi:10.2337/diab.45.11.1626 · Cited by 63 · see citing works
Kelpe, C. L., Johnson, L. M., & Poitout, V. (2002) · Endocrinology · doi:10.1210/en.2002-220402 · Cited by 63 · see citing works
Large, V., & Beylot, M. (1999) · Diabetes · doi:10.2337/diabetes.48.6.1251 · Cited by 60 · see citing works
Formation of oxaloacetate from pyruvate and carbon dioxide.
Mf, U., & KEECH, D. B. (1960) · PubMed · Cited by 59 · see citing works
MacDonald, M. J., Kaysen, J. H., Moran, S. M., & Pomije, C. E. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)54585-3 · Cited by 59 · see citing works
The Physiological Role of Pyruvate Carboxylation in Hamster Brown Adipose Tissue
Cannon, B., & Nedergaard, J. (1979) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1979.tb12909.x · Cited by 59 · see citing works
Amerindian Pyruvate Carboxylase Deficiency Is Associated with Two Distinct Missense Mutations
Carbone, M. A., MacKay, N., Ling, M., Cole, D. E. C., Douglas, C. E., Rigat, B. A., Feigenbaum, A. J., Clarke, J. T. R., Haworth, J. C., Greenberg, C. R., et al. (1998) · The American Journal of Human Genetics · doi:10.1086/301884 · Cited by 57 · see citing works
Andrikopoulos, S., & Proietto, J. (1995) · Diabetologia · doi:10.1007/bf00400598 · Cited by 56 · see citing works
Influence of Glucose on Pyruvate Carboxylase Expression in Pancreatic Islets
MacDonald, M. J. (1995) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1995.1274 · Cited by 56 · see citing works
Jitrapakdee, S., Gong, Q., MacDonald, M. J., & Wallace, J. C. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.51.34422 · Cited by 56 · see citing works
Self-citationThe Rat Pyruvate Carboxylase Gene Structure
Jitrapakdee, S., Booker, G. W., Cassady, A. I., & Wallace, J. C. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.33.20522 · Cited by 56 · see citing works
Self-citationWeinberg, M. B., & Utter, M. F. (1980) · Biochemical Journal · doi:10.1042/bj1880601 · Cited by 55 · see citing works
Induction of pyruvate carboxylase apoenzyme and holoenzyme in 3T3-L1 cells during differentiation
Freytag, S. O., & Utter, M. F. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.3.1321 · Cited by 54 · see citing works
Ling, Z.-C., Khan, A. W., Delauny, F., Davani, B., Östenson, C., Gustafsson, J.-Α., Okret, S., Landau, B. R., & Efendić, S. (1998) · Diabetologia · doi:10.1007/s001250050961 · Cited by 52 · see citing works
Liu, Y. Q., Tornheim, K., & Leahy, J. L. (1999) · Diabetes · doi:10.2337/diabetes.48.9.1747 · Cited by 47 · see citing works
Halestrap, A. P., & Armston, A. E. (1984) · Biochemical Journal · doi:10.1042/bj2230677 · Cited by 47 · see citing works
MacDonald, M. J., & Chang, C.-M. (1985) · Diabetes · doi:10.2337/diab.34.3.246 · Cited by 44 · see citing works
The mechanisms by which mild respiratory chain inhibitors inhibit hepatic gluconeogenesis
Owen, M. R., & Halestrap, A. P. (1993) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/0005-2728(93)90079-u · Cited by 41 · see citing works
Kajimoto, K., Terada, H., Baba, Y., & Shinohara, Y. (2005) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2005.01.006 · Cited by 39 · see citing works
Iizuka, K., Nakajima, H., Namba, M., Miyagawa, J.-I., Miyazaki, J., Hanafusa, T., & Matsuzawa, Y. (2002) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/s0925-4439(01)00082-5 · Cited by 37 · see citing works
Wise, L. S., Sul, H. S., & Rubin, C. S. (1984) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)42920-6 · Cited by 37 · see citing works
Liu, Y. Q., Moibi, J. A., & Leahy, J. L. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m307921200 · Cited by 36 · see citing works
Jitrapakdee, S., Adina-Zada, A., Besant, P. G., Surinya, K. H., Cleland, W. W., Wallace, J. C., & Attwood, P. V. (2007) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2007.03.016 · Cited by 35 · see citing works
Self-citationHyperglycemia contributes to impaired insulin response in GK rat islets.
Ling, Z. C., Hong-Lie, C., Östenson, C.-G., Efendić, S., & Khan, A. W. (2001) · Diabetes · doi:10.2337/diabetes.50.2007.s108 · Cited by 35 · see citing works
Interaction of Tumor Necrosis Factor-α- and Thiazolidinedione-Regulated Pathways in Obesity
Wellen, K. E., Uysal, K. T., Wiesbrock, S. M., Yang, Q., Chen, H., & Hotamışlıgil, G. S. (2004) · Endocrinology · doi:10.1210/en.2003-1580 · Cited by 33 · see citing works
Pyruvate carboxylase in genetic obesity
Lynch, C. J., McCall, K. M., Billingsley, M. L., Bohlen, L. M., Hreniuk, S. P., Martin, L. F., Witters, L. A., & Vannucci, S. J. (1992) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1992.262.5.e608 · Cited by 29 · see citing works
Structural and Promoter Regions of the Murine Pyruvate Carboxylase Gene
Jitrapakdee, S., Petchamphai, N., Sunyakumthorn, P., Wallace, J. C., & Boonsaeng, V. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.5599 · Cited by 23 · see citing works
Self-citationGruetter, R., Seaquist, E. R., & Uǧurbil, K. (2004) · Cited by 23 · see citing works
Angus, C., Lane, M. D., Rosenfeld, P. J., & Kelly, T. J. (1981) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(81)90252-7 · Cited by 21 · see citing works
Hazen, S. A., Waheed, A., Sly, W. S., LaNoue, K. F., & Lynch, C. J. (1997) · Developmental Neuroscience · doi:10.1159/000111202 · Cited by 21 · see citing works
Abe, S., Nakae, J., Yasoshima, K., Tajima, T., Shinohara, N., Murashita, M. M., Satoh, K., Koike, A., Takahashi, Y., & Fujieda, K. (1999) · American Journal of Medical Genetics · doi:10.1002/(sici)1096-8628(19990521)84:2 · Cited by 20 · see citing works
Liu, Y. Q., Han, J., Epstein, P. N., & Long, Y. S. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00427.2004 · Cited by 19 · see citing works
The stimulation of mitochondrial pyruvate carboxylation after dexamethasone treatment of rats
Martin, A. D., Allan, E. H., & Titheradge, M. A. (1984) · Biochemical Journal · doi:10.1042/bj2190107 · Cited by 18 · see citing works
Sunyakumthorn, P., Boonsaen, T., Boonsaeng, V., Wallace, J. C., & Jitrapakdee, S. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.01.108 · Cited by 17 · see citing works
Self-citationRegulation of the activity and synthesis of malic enzyme in 3T3-L1 cells
Goodridge, A. G., Fisch, J. E., & Glynias, M. J. (1984) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(84)90046-8 · Cited by 16 · see citing works
Khan, A. W., & Efendić, S. (1995) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1995.269.4.e623 · Cited by 15 · see citing works
Cannon, B., BERNSON, V. S. M., & Nedergaard, J. (1984) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/0005-2728(84)90264-0 · Cited by 14 · see citing works
Hexose metabolism in pancreatic islets: pyruvate carboxylase activity
Curi, R., Carpinelli, Â. R., & Malaisse, W. J. (1991) · Biochimie · doi:10.1016/0300-9084(91)90026-w · Cited by 13 · see citing works
Chandramouli, V., Khan, A. W., Östenson, C., Berggren, P., Löw, H., Landau, B. R., & Efendić, S. (1991) · Biochemical Journal · doi:10.1042/bj2780353 · Cited by 8 · see citing works
Goh, B.-H., Efendić, S., Khan, A., & Portwood, N. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)01242-7 · Cited by 3 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasion
Leone, R. D., Zhao, L., Englert, J. M., Sun, I.-M., Oh, M.-H., Sun, I.-H., Arwood, M. L., Bettencourt, I. A., Patel, C. H., Wen, J., et al. (2019) · Science · doi:10.1126/science.aav2588 · Cited by 1,169 · see citing works
Lactate: the ugly duckling of energy metabolism
Rabinowitz, J. D., & Enerbäck, S. (2020) · Nature Metabolism · doi:10.1038/s42255-020-0243-4 · Cited by 1,062 · see citing works
Glutamine reliance in cell metabolism
Yoo, H. C., Yu, Y. C., Sung, Y., & Han, J. M. (2020) · Experimental & Molecular Medicine · doi:10.1038/s12276-020-00504-8 · Cited by 1,021 · see citing works
Reprogramming of the Circadian Clock by Nutritional Challenge
Eckel‐Mahan, K. L., Patel, V. R., de Mateo, S., Orozco-Solís, R., Ceglia, N., Sahar, S., Dilag-Penilla, S. A., Dyar, K. A., Baldi, P., & Sassone‐Corsi, P. (2013) · Cell · doi:10.1016/j.cell.2013.11.034 · Cited by 711 · see citing works
Lee, S. Y., Jeong, E. K., Ju, M. K., Jeon, H. M., Kim, M. Y., Kim, C. H., Park, H. G., Han, S. I., & Kang, H. S. (2017) · Molecular Cancer · doi:10.1186/s12943-016-0577-4 · Cited by 579 · see citing works
Gluconeogenesis in dairy cows: The secret of making sweet milk from sour dough
Aschenbach, J. R., Kristensen, N. B., Donkin, S. S., Hammon, H. M., & Penner, G. B. (2010) · IUBMB Life · doi:10.1002/iub.400 · Cited by 529 · see citing works
Structure and function of biotin-dependent carboxylases
Tong, L. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1096-0 · Cited by 473 · see citing works
Nrf2–MafG heterodimers contribute globally to antioxidant and metabolic networks
Hirotsu, Y., Katsuoka, F., Funayama, R., Nagashima, T., Nishida, Y., Nakayama, K., Engel, J. D., & Yamamoto, M. P. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks827 · Cited by 431 · see citing works
Effective breast cancer combination therapy targeting BACH1 and mitochondrial metabolism
Lee, J., Yesilkanal, A. E., Wynne, J. P., Frankenberger, C. A., Liu, J., Yan, J., Elbaz, M., Rabe, D. C., Rustandy, F. D., Tiwari, P., et al. (2019) · Nature · doi:10.1038/s41586-019-1005-x · Cited by 380 · see citing works
Ketogenic Diet for Obesity: Friend or Foe?
Paoli, A. (2014) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph110202092 · Cited by 362 · see citing works
Metabolic adaptation in hypoxia and cancer
Paredes, F., Williams, H. C., & Martín, A. S. (2021) · Cancer Letters · doi:10.1016/j.canlet.2020.12.020 · Cited by 269 · see citing works
Ketosis, ketogenic diet and food intake control: a complex relationship
Paoli, A., Bosco, G., Camporesi, E. M., & Mangar, D. (2015) · Frontiers in Psychology · doi:10.3389/fpsyg.2015.00027 · Cited by 260 · see citing works
Regulation of Tumor Progression by Programmed Necrosis
Lee, S. Y., Ju, M. K., Jeon, H. M., Jeong, E. K., Lee, Y. J., Kim, C. H., Park, H. G., Han, S. I., & Kang, H. S. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/3537471 · Cited by 225 · see citing works
Ketogenic Diet in Neuromuscular and Neurodegenerative Diseases
Paoli, A., Bianco, A., Damiani, E., & Bosco, G. (2014) · BioMed Research International · doi:10.1155/2014/474296 · Cited by 221 · see citing works
Jitrapakdee, S. (2011) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2011.10.001 · Cited by 189 · see citing works
Self-citationWnt/Snail Signaling Regulates Cytochrome c Oxidase and Glucose Metabolism
Lee, S. Y., Jeon, H. M., Ju, M. K., Kim, C. H., Yoon, G., Han, S. I., Park, H. G., & Kang, H. S. (2012) · Cancer Research · doi:10.1158/0008-5472.can-12-0006 · Cited by 195 · see citing works
Carnitine, mitochondrial function and therapy
Zammit, V. A., Ramsay, R. R., Bonomini, M., & Arduini, A. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2009.04.024 · Cited by 149 · see citing works
Targeting Pyruvate Carboxylase Reduces Gluconeogenesis and Adiposity and Improves Insulin Resistance
Kumashiro, N., Beddow, S. A., Vatner, D. F., Majumdar, S. K., Cantley, J. L., Guebre‐Egziabher, F., Fat, I., Guigni, B. A., Jurczak, M. J., Birkenfeld, A. L., et al. (2013) · Diabetes · doi:10.2337/db12-1311 · Cited by 153 · see citing works
Sasaki, K., Omri, A. E., Kondo, S., Han, J., & Isoda, H. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.10.010 · Cited by 152 · see citing works
Domain Architecture of Pyruvate Carboxylase, a Biotin-Dependent Multifunctional Enzyme
Maurice, M. S., Reinhardt, L. A., Surinya, K. H., Attwood, P. V., Wallace, J. C., Cleland, W. W., & Rayment, I. (2007) · Science · doi:10.1126/science.1144504 · Cited by 151 · see citing works
Self-citationThe Role of TCA Cycle Anaplerosis in Ketosis and Fatty Liver in Periparturient Dairy Cows
White, H. M. (2015) · Animals · doi:10.3390/ani5030384 · Cited by 148 · see citing works
Compensatory Responses to Pyruvate Carboxylase Suppression in Islet β-Cells
Jensen, M. V., Joseph, J. W., Ilkayeva, O., Burgess, S. C., Lu, D., Ronnebaum, S. M., Odegaard, M. L., Becker, T. C., Sherry, A. D., & Newgard, C. B. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m604350200 · Cited by 144 · see citing works
Xiang, S., & Tong, L. (2008) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1393 · Cited by 139 · see citing works
Alkhalidy, H., Moore, W., Wang, Y., Luo, J., McMillan, R. P., Wei, Z., Zhou, K., & Liu, D. (2018) · Molecules · doi:10.3390/molecules23092338 · Cited by 139 · see citing works
Grover, K., Koblova, A., Pezacki, A. T., Chang, C. J., & New, E. J. (2024) · Chemical Reviews · doi:10.1021/acs.chemrev.3c00819 · Cited by 129 · see citing works
Pyruvate carboxylase and cancer progression
Kiesel, V. A., Sheeley, M. P., Coleman, M. F., Kulkoyluoglu‐Cotul, E., Donkin, S. S., Hursting, S. D., Wendt, M. K., & Teegarden, D. (2021) · Cancer & Metabolism · doi:10.1186/s40170-021-00256-7 · Cited by 123 · see citing works
Desideri, E., Vegliante, R., & Ciriolo, M. R. (2014) · Cancer Letters · doi:10.1016/j.canlet.2014.02.023 · Cited by 113 · see citing works
Wiederkehr, A., & Wollheim, C. B. (2008) · Cell Calcium · doi:10.1016/j.ceca.2007.11.004 · Cited by 100 · see citing works
Nutrition and Acne: Therapeutic Potential of Ketogenic Diets
Paoli, A., Grimaldi, K. A., Toniolo, L., Canato, M., Bianco, A., & Fratter, A. (2012) · Skin Pharmacology and Physiology · doi:10.1159/000336404 · Cited by 97 · see citing works
Hasan, N. M., Longacre, M. J., Stoker, S. W., Boonsaen, T., Jitrapakdee, S., Kendrick, M. A., Wallace, J. C., & MacDonald, M. J. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m804170200 · Cited by 88 · see citing works
Self-citationRoles of pyruvate carboxylase in human diseases: from diabetes to cancers and infection
Lao-On, U., Attwood, P. V., & Jitrapakdee, S. (2018) · Journal of Molecular Medicine · doi:10.1007/s00109-018-1622-0 · Cited by 83 · see citing works
Self-citationRegulation of the structure and activity of pyruvate carboxylase by acetyl CoA
Adina-Zada, A., Zeczycki, T. N., & Attwood, P. V. (2011) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2011.11.015 · Cited by 84 · see citing works
Luo, X., Li, R., & Yan, L. (2015) · Journal of Diabetes Research · doi:10.1155/2015/512618 · Cited by 77 · see citing works
H2S-induced S-sulfhydration of pyruvate carboxylase contributes to gluconeogenesis in liver cells
Ju, Y., Untereiner, A. A., Wu, L., & Yang, G. (2015) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2015.08.003 · Cited by 76 · see citing works
Pinweha, P., Rattanapornsompong, K., Charoensawan, V., & Jitrapakdee, S. (2016) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2016.05.005 · Cited by 75 · see citing works
Self-citationComprehensive and quantitative proteome profiling of the mouse liver and plasma
Lai, K. K. Y., Kolippakkam, D. N., & Beretta, L. (2008) · Hepatology · doi:10.1002/hep.22123 · Cited by 69 · see citing works
Latorre‐Muro, P., Baeza, J., Armstrong, E. A., Hurtado‐Guerrero, R., Corzana, F., Wu, L. E., Sinclair, D. A., López‐Buesa, P., Carrodeguas, J. A., & Denu, J. M. (2018) · Molecular Cell · doi:10.1016/j.molcel.2018.07.031 · Cited by 68 · see citing works
Lee, S. Y., Ju, M. K., Jeon, H. M., Lee, Y. J., Kim, C. H., Park, H. G., Han, S. I., & Kang, H. S. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/1027453 · Cited by 67 · see citing works
Plasma and urine metabolic fingerprinting of type 1 diabetic children
Balderas, C., Rupérez, F. J., Ibáñez, E., Señorans, J., Guerrero-Fernández, J., Casado, I. G., Gracia‐Bouthelier, R., Garcı́a, A., & Barbas, C. (2013) · Electrophoresis · doi:10.1002/elps.201300062 · Cited by 67 · see citing works
A Symmetrical Tetramer for S. aureus Pyruvate Carboxylase in Complex with Coenzyme A
Yu, L. P. C., Xiang, S., Lasso, G., Gil‐Carton, D., Valle, M., & Tong, L. (2009) · Structure · doi:10.1016/j.str.2009.04.008 · Cited by 65 · see citing works
Blombach, B., & Takors, R. (2015) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2015.00108 · Cited by 65 · see citing works
Prohibitin has an important role in adipocyte differentiation
Ande, S. R., Xu, Z., Gu, Y., & Mishra, S. (2011) · International Journal of Obesity · doi:10.1038/ijo.2011.227 · Cited by 62 · see citing works
Glial Dysfunction Causes Age-Related Memory Impairment in Drosophila
Yamazaki, D., Horiuchi, J., Ueno, K., Ueno, T., Saeki, S., Matsuno, M., Naganos, S., Miyashita, T., Hirano, Y., Nishikawa, H., et al. (2014) · Neuron · doi:10.1016/j.neuron.2014.09.039 · Cited by 62 · see citing works
Nishitani, S., Fukuhara, A., Shin, J., Okuno, Y., Otsuki, M., & Shimomura, I. (2018) · Scientific Reports · doi:10.1038/s41598-018-27181-y · Cited by 62 · see citing works
Kobayashi, M., Deguchi, Y., Nozaki, Y., & Higami, Y. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22116025 · Cited by 60 · see citing works
Okita, N., Hayashida, Y., Kojima, Y., Fukushima, M., Yuguchi, K., Mikami, K., Yamauchi, A., Watanabe, K., Noguchi, M., Nakamura, M., et al. (2012) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2012.02.003 · Cited by 57 · see citing works
Storm, J., Sethia, S., Blackburn, G., Chokkathukalam, A., Watson, D., Breitling, R., Coombs, G., & Müller, S. (2014) · PLoS Pathogens · doi:10.1371/journal.ppat.1003876 · Cited by 54 · see citing works
Changes in energy metabolism induced by fluoride: Insights from inside the mitochondria
Araújo, T. T., Pereira, H. A. B. S., Dionizio, A. S., Sanchez, C. D. C., Carvalho, T. D. S., Fernandes, M. D. S., & Buzalaf, M. A. R. (2019) · Chemosphere · doi:10.1016/j.chemosphere.2019.124357 · Cited by 53 · see citing works
Corino, C., Fiego, D. P. L., Macchioni, P., Pastorelli, G., Giancamillo, A. D., Domeneghini, C., & Rossi, R. (2006) · Meat Science · doi:10.1016/j.meatsci.2006.10.007 · Cited by 53 · see citing works
Proteomics of human mitochondria
Palmfeldt, J., & Bross, P. (2016) · Mitochondrion · doi:10.1016/j.mito.2016.07.006 · Cited by 53 · see citing works
Wahl, A., Sidorenko, Y., Dauner, M., Genzel, Y., & Reichl, U. (2008) · Biotechnology and Bioengineering · doi:10.1002/bit.21873 · Cited by 51 · see citing works
Lietzan, A. D., Menefee, A. L., Zeczycki, T. N., Kumar, S., Attwood, P. V., Wallace, J. C., Cleland, W. W., & Maurice, M. S. (2011) · Biochemistry · doi:10.1021/bi201277j · Cited by 49 · see citing works
Self-citationFoulquier, F., & Legrand, D. (2020) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2020.129674 · Cited by 48 · see citing works
Inhibitors of Pyruvate Carboxylase~!2009-12-01~!2010-02-01~!2010-04-15~!
Zeczycki, T. N., Maurice, M. S., & Attwood, P. V. (2010) · The Open Enzyme Inhibition Journal · doi:10.2174/1874940201003010008 · Cited by 48 · see citing works
Zhang, W., Zhang, M., Gao, C., Zhang, Y., Ge, Y., Guo, S., Guo, X., Zhou, Z., Liu, Q., Zhang, Y., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1619034114 · Cited by 46 · see citing works
Larrick, B., Kim, K., Donkin, S. S., & Teegarden, D. (2018) · Nutrition Research · doi:10.1016/j.nutres.2018.07.004 · Cited by 47 · see citing works
Sanders, E. B., & Diehl, S. (2015) · Oncoscience · doi:10.18632/oncoscience.128 · Cited by 42 · see citing works
Yang, X., Song, J., & Yan, L. (2019) · Antioxidants · doi:10.3390/antiox8020032 · Cited by 41 · see citing works
Wilmanski, T. M., Buhman, K. K., Donkin, S. S., Burgess, J. R., & Teegarden, D. (2016) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2016.11.006 · Cited by 37 · see citing works
Rajas, F., Jourdan‐Pineau, H., Stefanutti, A., Mrad, E. A., Iynedjian, P. B., & Mithieux, G. (2007) · Histochemistry and Cell Biology · doi:10.1007/s00418-006-0263-5 · Cited by 37 · see citing works
Insight into the Carboxyl Transferase Domain Mechanism of Pyruvate Carboxylase from Rhizobium etli
Zeczycki, T. N., Maurice, M. S., Jitrapakdee, S., Wallace, J. C., Attwood, P. V., & Cleland, W. W. (2009) · Biochemistry · doi:10.1021/bi9003759 · Cited by 36 · see citing works
Self-citationZeczycki, T. N., Menefee, A. L., Adina-Zada, A., Jitrapakdee, S., Surinya, K. H., Wallace, J. C., Attwood, P. V., Maurice, M. S., & Cleland, W. W. (2011) · Biochemistry · doi:10.1021/bi2012788 · Cited by 35 · see citing works
Self-citationLiu, J., Guo, L., Yin, F., Zhang, Y., Liu, Z., & Wang, Y. (2013) · PLoS ONE · doi:10.1371/journal.pone.0078315 · Cited by 34 · see citing works
Peng, M., Han, J. D. J., Li, L., & Ma, H. (2016) · Scientific Reports · doi:10.1038/srep32580 · Cited by 34 · see citing works
Nicotinamide Adenine Dinucleotide: The Redox Sensor in Aging-Related Disorders
Schiuma, G., Lara, D., Clement, J. P., Narducci, M., & Rizzo, R. (2024) · Antioxidants and Redox Signaling · doi:10.1089/ars.2023.0375 · Cited by 33 · see citing works
White, H. M., Koser, S. L., & Donkin, S. S. (2011) · Journal of Dairy Science · doi:10.3168/jds.2010-3960 · Cited by 33 · see citing works
A Substrate-induced Biotin Binding Pocket in the Carboxyltransferase Domain of Pyruvate Carboxylase
Lietzan, A. D., & Maurice, M. S. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.477828 · Cited by 32 · see citing works
Pyruvate carboxylase promotes thyroid cancer aggressiveness through fatty acid synthesis
Liu, C., Zhou, X., Pan, Y., Liu, Y., & Zhang, Y. (2021) · BMC Cancer · doi:10.1186/s12885-021-08499-9 · Cited by 32 · see citing works
Teixeira, A. P., Santos, S. S., Carinhas, N., Oliveira, R., & Alves, P. M. (2007) · Neurochemistry International · doi:10.1016/j.neuint.2007.08.007 · Cited by 32 · see citing works
Gattu, A. K., Birkenfeld, A. L., Iwakiri, Y., Jay, S. M., Saltzman, W. M., Doll, J. A., Protiva, P., Samuel, V. T., Crawford, S. E., & Chung, C. (2014) · Endocrinology · doi:10.1210/en.2013-1785 · Cited by 31 · see citing works
Cao, Z., Zhou, Y., Zhu, S., Feng, J. J., Chen, X., Liu, S., Peng, N., Yang, X., Xu, G., & Zhu, Y. (2016) · Scientific Reports · doi:10.1038/srep22002 · Cited by 30 · see citing works
Protein carbonylation in dopaminergic cells exposed to rotenone
Chiaradia, E., Renzone, G., Scaloni, A., Caputo, M., Costanzi, E., Gambelunghe, A., Muzi, G., Avellini, L., Emiliani, C., & Buratta, S. (2019) · Toxicology Letters · doi:10.1016/j.toxlet.2019.04.002 · Cited by 30 · see citing works
Germ-Free Swiss Webster Mice on a High-Fat Diet Develop Obesity, Hyperglycemia, and Dyslipidemia
Logan, I. E., Bobe, G., Miranda, C. L., Vasquez‐Perez, S., Choi, J., Lowry, M. B., Sharpton, T. J., Morgun, A., Maier, C. S., Stevens, J. F., et al. (2020) · Microorganisms · doi:10.3390/microorganisms8040520 · Cited by 31 · see citing works
Metabolic and oncogenic adaptations to pyruvate dehydrogenase inactivation in fibroblasts
Wang, H., Lu, J. L., Kulkarni, S., Zhang, W., Gorka, J. E., Mandel, J. A., Goetzman, E. S., & Prochownik, E. V. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.005200 · Cited by 29 · see citing works
Bailey, L. M., Ivanov, R. A., Jitrapakdee, S., Wilson, C. J., Wallace, J. C., & Polyak, S. W. (2008) · Human Mutation · doi:10.1002/humu.20766 · Cited by 27 · see citing works
Self-citationChavalit, T., Rojvirat, P., Muangsawat, S., & Jitrapakdee, S. (2013) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2013.05.001 · Cited by 26 · see citing works
Self-citationMenefee, A. L., & Zeczycki, T. N. (2014) · FEBS Journal · doi:10.1111/febs.12713 · Cited by 25 · see citing works
Activation and Inhibition of Pyruvate Carboxylase from Rhizobium etli
Zeczycki, T. N., Menefee, A. L., Jitrapakdee, S., Wallace, J. C., Attwood, P. V., Maurice, M. S., & Cleland, W. W. (2011) · Biochemistry · doi:10.1021/bi201276r · Cited by 25 · see citing works
Self-citationWirth, M., Karaca, S., Wenzel, D., Ho, L., Tishkoff, D. X., Lombard, D. B., Verdin, E. M., Urlaub, H., Jedrusik, M. A., & Fischle, W. (2013) · Mitochondrion · doi:10.1016/j.mito.2013.02.002 · Cited by 22 · see citing works
Investigation of adipocyte proteome during the differentiation of brown preadipocytes
Kamal, A. H. M., Kim, W. K., Cho, K., Park, A., Min, J., Han, B., Park, S. G., Lee, S. C., & Bae, K. (2013) · Journal of Proteomics · doi:10.1016/j.jprot.2013.10.005 · Cited by 23 · see citing works
Insights into Transcriptional Regulation of Hepatic Glucose Production
Anyamaneeratch, K., Rojvirat, P., Sukjoi, W., & Jitrapakdee, S. (2015) · International review of cytology · doi:10.1016/bs.ircmb.2015.05.004 · Cited by 23 · see citing works
Self-citationIstfan, N., Hasson, B., Apovian, C., Meshulam, T., Yu, L., Anderson, W., & Corkey, B. E. (2021) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00094.2021 · Cited by 22 · see citing works
White, H. M., Koser, S. L., & Donkin, S. S. (2012) · Journal of Dairy Science · doi:10.3168/jds.2011-4644 · Cited by 22 · see citing works
Ochoa-Ruiz, E., Díaz-Ruiz, R., Hernández-Vázquez, A. D. J., Ibarra‐González, I., Ortíz-Plata, A., Rembao, D., Ortega-Cuéllar, D., Viollet, B., Uribe‐Carvajal, S., Corella, J. A., et al. (2015) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2015.08.009 · Cited by 22 · see citing works
Heterotrophic Carbon Fixation in a Salamander-Alga Symbiosis
Burns, J. A., Kerney, R. R., & Duhamel, S. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.01815 · Cited by 22 · see citing works
Assessment of hepatic pyruvate carboxylase activity using hyperpolarized [1‐13C]‐ l ‐lactate
Chen, J., Hackett, E. P., Kovács, Z., Malloy, C. R., & Park, J. M. (2020) · Magnetic Resonance in Medicine · doi:10.1002/mrm.28489 · Cited by 22 · see citing works
White, H. M., Carvalho, E. R., Koser, S. L., Schmelz-Roberts, N. S., Pezzanite, L. M., Slabaugh, A., Doane, P. H., & Donkin, S. S. (2015) · Journal of Dairy Science · doi:10.3168/jds.2015-9953 · Cited by 21 · see citing works
Hepatotoxicity assessment of Rhizoma Paridis in adult zebrafish through proteomes and metabolome
Jia, Z., Zhao, C., Wang, M., Zhao, X., Zhang, W., Han, T., Xia, Q., Han, Z., Lin, R., & Li, X.-R. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.109558 · Cited by 21 · see citing works
Thonpho, A., Rojvirat, P., Jitrapakdee, S., & MacDonald, M. J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0055139 · Cited by 20 · see citing works
Self-citationHan, S. J., Choi, S., Yi, S., Jung, J. G., Jung, I., Shin, M., Kang, S. Y., Oh, H., Kim, H. J., Kim, D. J., et al. (2016) · Scientific Reports · doi:10.1038/srep37468 · Cited by 20 · see citing works
Boonsaen, T., Rojvirat, P., Surinya, K. H., Wallace, J. C., & Jitrapakdee, S. (2007) · Biochemical Journal · doi:10.1042/bj20070276 · Cited by 20 · see citing works
Self-citationCloning the Genomic Sequence and Identification of Promoter Regions of Bovine Pyruvate Carboxylase
Hazelton, S. R., Spurlock, D. M., Bidwell, C. A., & Donkin, S. S. (2007) · Journal of Dairy Science · doi:10.3168/jds.2007-0542 · Cited by 20 · see citing works
Regulation of bovine pyruvate carboxylase mRNA and promoter expression by thermal stress1
White, H. M., Koser, S. L., & Donkin, S. S. (2012) · Journal of Animal Science · doi:10.2527/jas.2010-3408 · Cited by 18 · see citing works
Interplay Between Glucose Metabolism and Chromatin Modifications in Cancer
Ma, R., Wu, Y., Li, S., & Yu, X. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.654337 · Cited by 18 · see citing works
Tenorio-Laranga, J., Männistö, P., Karayiorgou, M., Gogos, J., & García-Horsman, J. A. (2009) · Biochemical Pharmacology · doi:10.1016/j.bcp.2009.02.004 · Cited by 19 · see citing works
Pinweha, P., Phillips, C. A., Gregory, P. A., Li, X., Chuayboonya, P., Mongkolsiri, P., Goodall, G. J., & Jitrapakdee, S. (2019) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2019.108169 · Cited by 17 · see citing works
Self-citationCruz-Moreno, D. G., Hernández-Aguirre, L. E., Peregrino-Uriarte, A. B., Leyva‐Carrillo, L., Gómez‐Jiménez, S., Contreras‐Vergara, C. A., Hernández‐López, J., & Yepiz-Plascencia, G. M. (2024) · Journal of Experimental Marine Biology and Ecology · doi:10.1016/j.jembe.2024.152052 · Cited by 16 · see citing works
Anaplerosis in cancer: Another step beyond the warburg effect
Ochoa-Ruiz, E., & Díaz-Ruiz, R. (2012) · American Journal of Molecular Biology · doi:10.4236/ajmb.2012.24031 · Cited by 16 · see citing works
Westerhold, L. E., Bridges, L. C., Shaikh, S. R., & Zeczycki, T. N. (2017) · Biochemistry · doi:10.1021/acs.biochem.7b00383 · Cited by 16 · see citing works
Obeidat, M. D., Alkhateeb, M. E. M., Jawasreh, K. I. Z., Riley, D. G., & Sukhni, I. A. A. (2024) · Scientific Reports · doi:10.1038/s41598-024-68138-8 · Cited by 14 · see citing works
- Authors
- Jitrapakdee, S., Vidal-Puig, A., & Wallace, J. C.
- Affiliations
- Mahidol University (TH)
- The University of Adelaide (AU)
- Corresponding author
- Jitrapakdee, S.
- ORCID
- Jitrapakdee, S.
- Venue
- Cellular and Molecular Life Sciences
- Published
- 2006-02-28
- Volume
- 63
- Issue
- 7-8
- Pages
- 843-854
- ISSN
- 1420-682X (ISSN-L)
- 1420-9071
- PMC
- PMC11136034
- OpenAlex
- W1986860566
- Cited by
- 149
- References
- 97
- Citations by year
- 2026: 5 · 2025: 2 · 2024: 8 · 2023: 4 · 2022: 2 · 2021: 10 · 2020: 9 · 2019: 12 · 2018: 9 · 2017: 3 · 2016: 7 · 2015: 10 · 2014: 12 · 2013: 12 · 2012: 12
- FWCI
- 2.87
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Cellular and Molecular Life Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Biochemical Acid Research Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Keywords
- pyruvate carboxylase, anaplerosis, TCA cycle, oxaloacetate, gluconeogenesis, fatty acid synthesis, glyceroneogenesis, PPARγ, metabolic switch, lipogenesis, glucose-stimulated insulin secretion, malate, islets, astrocytes, glutamate synthesis, hyperglycemia, hyperlipidemia, tissue-specific gene expression, transcription factors
- MeSH terms
- Animals, Humans, Kidney, Liver, Pancreas, Pyruvate Carboxylase, Signal Transduction, Pyruvic Acid, Oxaloacetic Acid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review