Cited by 150Biochemical Acid Research StudiesMetabolism, Diabetes, and CancerMitochondrial Function and Pathology

Anaplerotic roles of pyruvate carboxylase in mammalian tissues

Open access
Jitrapakdee, S., Vidal-Puig, A., Wallace, J. C.·2006·Cellular and Molecular Life Sciences

Abstract

Pyruvate carboxylase (PC) catalyzes the ATP-dependent carboxylation of pyruvate to oxaloacetate. PC serves an anaplerotic role for the tricarboxylic acid cycle, when intermediates are removed for different biosynthetic purposes. In liver and kidney, PC provides oxaloacetate for gluconeogenesis. In adipocytes PC is involved in de novo fatty acid synthesis and glyceroneogenesis, and is regulated by the peroxisome proliferator-activated receptor-gamma, suggesting that PC is involved in the metabolic switch controlling fuel partitioning toward lipogenesis. In islets, PC is necessary for glucose-induced insulin secretion by providing oxaloacetate to form malate that participates in the 'pyruvate/malate cycle' to shuttle 3C or 4C between mitochondria and cytoplasm. Hyperglycemia and hyperlipidemia impair this cycle and affect glucose-stimulated insulin release. In astrocytes, PC is important for de novo synthesis of glutamate, an important excitatory neurotransmitter supplied to neurons. Transcriptional studies of the PC gene pinpoint some transcription factors that determine tissue-specific expression.

Integrity signals

Registry

Crossref · 10.1007/s00018-005-5410-y

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97 of 97 references verified0 citation errors · 0 not checkable

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  • PC-mediated alternative anaplerosis is important in liver cancers and glioblastoma for maintaining biosynthesis and redox homeostasis.

    “This PC-mediated alternative anaplerosis is considered important in specific types of cancers, including liver cancers and glioblastoma, for maintaining biosynthesis and redox homeostasis154–156.”

    From Glutamine reliance in cell metabolism (2020) · cites this paper as [154]

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Authors
Jitrapakdee, S., Vidal-Puig, A., & Wallace, J. C.
Affiliations
  • Mahidol University (TH)
  • The University of Adelaide (AU)
Corresponding author
Jitrapakdee, S.
Venue
Cellular and Molecular Life Sciences
Published
2006-02-28
Volume
63
Issue
7-8
Pages
843-854
ISSN
  • 1420-682X (ISSN-L)
  • 1420-9071
OpenAlex
W1986860566
Cited by
149
References
97
Citations by year
2026: 5 · 2025: 2 · 2024: 8 · 2023: 4 · 2022: 2 · 2021: 10 · 2020: 9 · 2019: 12 · 2018: 9 · 2017: 3 · 2016: 7 · 2015: 10 · 2014: 12 · 2013: 12 · 2012: 12
FWCI
2.87
Type
journal article
Language
en
Open access
Locations
  • Cellular and Molecular Life Sciences (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Biochemical Acid Research Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Keywords
pyruvate carboxylase, anaplerosis, TCA cycle, oxaloacetate, gluconeogenesis, fatty acid synthesis, glyceroneogenesis, PPARγ, metabolic switch, lipogenesis, glucose-stimulated insulin secretion, malate, islets, astrocytes, glutamate synthesis, hyperglycemia, hyperlipidemia, tissue-specific gene expression, transcription factors
MeSH terms
Animals, Humans, Kidney, Liver, Pancreas, Pyruvate Carboxylase, Signal Transduction, Pyruvic Acid, Oxaloacetic Acid

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