Cited by 216Plant biochemistry and biosynthesisPlant Molecular Biology ResearchLipid metabolism and biosynthesis

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Regulation of HMG-CoA reductase activity in plants.

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Stermer, B A, Bianchini, G M, Korth, K L·1994·Journal of Lipid Research

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Abstract

This brief review summarizes the current literature on the regulation of HMG-CoA reductase (HMGR) in plants. The mevalonate pathway, which starts with the synthesis of mevalonate by HMGR, has more branch pathways in plants than in most other organisms, leading to a tremendous variety of isoprenoid products. Evidence suggests that HMGR is an important control point for the synthesis of many of these plant isoprenoids, including some that are vital for primary metabolism and pest resistance. Plant HMGR activity responds in vivo to a variety of developmental and environmental signals, such as cell division, light, and infection. Plants regulate HMGR activity at the level of mRNA by differential induction of HMGR gene family members, and posttranslationally by enzyme modification. Calcium, calmodulin, and proteolytic degradation may also have a role in regulation of plant HMGR.

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Authors: Stermer, B. A., Bianchini, G. M., & Korth, K. L.
Affiliations: Noble Research Institute (US)
ORCID: Korth, K L
Venue: Journal of Lipid Research
Publisher: Elsevier BV
Published: 1994-07
Volume: 35
Issue: 7
Pages: 1133-1140
ISSN: 0022-2275 (ISSN-L)
DOI: 10.1016/s0022-2275(20)39958-2
OpenAlex: W2340545711
Cited by: 216
References: 58
Citations by year: 2026: 3 · 2025: 3 · 2024: 7 · 2023: 5 · 2022: 12 · 2021: 6 · 2020: 5 · 2019: 9 · 2018: 7 · 2017: 10 · 2016: 5 · 2015: 8 · 2014: 6 · 2013: 7 · 2012: 6
FWCI: 3.42
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 9588 d)
Locations: Journal of Lipid Research (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant biochemistry and biosynthesis
Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
Keywords: HMG-CoA reductase, mevalonate pathway, isoprenoid biosynthesis, enzyme regulation, gene expression regulation, post-translational modification, calcium signaling, calmodulin, proteolysis, plant development, light signaling, plant-pathogen interaction, pest resistance, primary metabolism
MeSH terms: Calcium, Cell Compartmentation, Hydroxymethylglutaryl CoA Reductases, Peptide Hydrolases, Phosphorylation, Plants, Transcription, Genetic, Signal Transduction

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Regulation of HMG-CoA reductase activity in plants.

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