The DOI matches its Crossref record; 56 of the 58 references it cites were found in a registry or an index.
Regulation of HMG-CoA reductase activity in plants.
Open accessAbstract
This brief review summarizes the current literature on the regulation of HMG-CoA reductase (HMGR) in plants. The mevalonate pathway, which starts with the synthesis of mevalonate by HMGR, has more branch pathways in plants than in most other organisms, leading to a tremendous variety of isoprenoid products. Evidence suggests that HMGR is an important control point for the synthesis of many of these plant isoprenoids, including some that are vital for primary metabolism and pest resistance. Plant HMGR activity responds in vivo to a variety of developmental and environmental signals, such as cell division, light, and infection. Plants regulate HMGR activity at the level of mRNA by differential induction of HMGR gene family members, and posttranslationally by enzyme modification. Calcium, calmodulin, and proteolytic degradation may also have a role in regulation of plant HMGR.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Stermer et al. showed that the HMGR activity is much reduced in mature tissues, correlating well with the results presented here [27].”
From Relative expression of genes of terpene metabolism in different tissues of Artemisia annuaL (2011) · cites this paper as [27]
Citations
Cites
Regulation of the mevalonate pathway
Goldstein, J. L., & Brown, M. S. (1990) · Nature · doi:10.1038/343425a0 · Cited by 5,394
Wani, M. C., Taylor, H. L., Wall, M. E., COGGON, P., & McPhail, A. T. (1971) · Journal of the American Chemical Society · doi:10.1021/ja00738a045 · Cited by 4,083
An Introduction to Plant Biochemistry
(1934) · Nature · doi:10.1038/134795b0 · Cited by 451
3-Hydroxy-3-methylglutaryl Coenzyme A Reductase
Brown, M. S., Dana, S. E., Dietschy, J. M., & Siperstein, M. D. (1973) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)43725-3 · Cited by 234
Choi, D., Ward, B., & Bostock, R. M. (1992) · The Plant Cell · doi:10.1105/tpc.4.10.1333 · Cited by 224
Growth and Differentiation in Plants
Phillips, I. D. J., & Wareing, P. F. (1985) · Medical Entomology and Zoology · Cited by 221
The Role of Plastids in Isoprenoid Biosynthesis
Kleinig, H. (1989) · Annual Review of Plant Physiology and Plant Molecular Biology · doi:10.1146/annurev.pp.40.060189.000351 · Cited by 207
Introduction of plant biochemistry
Brown, E. G. (1983) · Phytochemistry · doi:10.1016/s0031-9422(00)97730-6 · Cited by 197
Roitelman, J., Olender, E. H., Bar‐Nun, S., Dunn, W. A., & Simoni, R. (1992) · The Journal of Cell Biology · doi:10.1083/jcb.117.5.959 · Cited by 185
Current Topics in Plant Biochemistry and Physiology
Randall, D. D. (1988) · Cited by 180
Research works printed but not linked: 2
- Kuc, 1982, Phytolaexins from the Solanaceae, In Phytoalexins. J. A. Bailey and J. W. Mansfield, editors. John Wiley and Sons, New York., 81
- Knight, J. S. 1982. Studies on the protein kinase which catalyzes the inactivation of microsomal HMG-CoA reduc?tase. Senior thesis, University of Otago, Dunedin, New Zealand.
Cited by
Sorted by citations
Network Analysis of the MVA and MEP Pathways for Isoprenoid Synthesis
Vranová, E., Coman, D., & Gruissem, W. (2013) · Annual Review of Plant Biology · doi:10.1146/annurev-arplant-050312-120116 · Cited by 1,168
Hemmerlin, A., Hoeffler, J., Meyer, O., Tritsch, D., Kagan, I. A., Grosdemange‐Billiard, C., Rohmer, M., & Bach, T. J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m302526200 · Cited by 442
Biosynthesis and biotechnological production of ginsenosides
Kim, Y.-J., Zhang, D., & Yang, D. (2015) · Biotechnology Advances · doi:10.1016/j.biotechadv.2015.03.001 · Cited by 387
A raison d’être for two distinct pathways in the early steps of plant isoprenoid biosynthesis?
Hemmerlin, A., Harwood, J. L., & Bach, T. J. (2011) · Progress in Lipid Research · doi:10.1016/j.plipres.2011.12.001 · Cited by 371
The potential of the mevalonate pathway for enhanced isoprenoid production
Liao, P., Hemmerlin, A., Bach, T. J., & Chye, M. (2016) · Biotechnology Advances · doi:10.1016/j.biotechadv.2016.03.005 · Cited by 336
Metadata
- Authors
- Stermer, B. A., Bianchini, G. M., & Korth, K. L.
- Affiliations
- Noble Research Institute (US)
- ORCID
- Korth, K L
- Venue
- Journal of Lipid Research
- Publisher
- Elsevier BV
- Published
- 1994-07
- Volume
- 35
- Issue
- 7
- Pages
- 1133-1140
- ISSN
- 0022-2275 (ISSN-L)
- OpenAlex
- W2340545711
- Cited by
- 216
- References
- 58
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 7 · 2023: 5 · 2022: 12 · 2021: 6 · 2020: 5 · 2019: 9 · 2018: 7 · 2017: 10 · 2016: 5 · 2015: 8 · 2014: 6 · 2013: 7 · 2012: 6
- FWCI
- 3.42
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Lipid Research (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant biochemistry and biosynthesis
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Keywords
- HMG-CoA reductase, mevalonate pathway, isoprenoid biosynthesis, enzyme regulation, gene expression regulation, post-translational modification, calcium signaling, calmodulin, proteolysis, plant development, light signaling, plant-pathogen interaction, pest resistance, primary metabolism
- MeSH terms
- Calcium, Cell Compartmentation, Hydroxymethylglutaryl CoA Reductases, Peptide Hydrolases, Phosphorylation, Plants, Transcription, Genetic, Signal Transduction
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
