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Lipid organization in pig stratum corneum.
Open accessAbstract
The lipid and keratin structure of pig stratum corneum has been elucidated by small- and wide-angle X-ray diffraction. The measurements were carried out as a function of hydration and temperature. In addition, the stratum corneum was measured after recrystallization of the lipids at various temperatures. The results led us to conclude that the intercellular lipids in the stratum corneum are organized in at least two different lamellar structures with repeat distances of 6 and 13.2 nm. There is an indication for the presence of a third phase with a periodicity of 9 nm. The wide-angle pattern revealed a hexagonal (0.414 nm spacing) and liquid lateral packing (approximately 0.46 nm spacing). The 0.414 nm reflection started to decrease in intensity between 60 and 66 degrees C and disappeared between 72 and 95 degrees C. Furthermore, crystalline cholesterol has been indicated by both, wide- and small-angle X-ray diffraction, while the reflections of alpha-keratin were observed in the wide-angle X-ray diffraction pattern.
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Cited by
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Bouwstra, J. A., & Ponec, M. (2006) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2006.06.021 · Cited by 666
Self-citationVesicles as a tool for transdermal and dermal delivery
Honeywell-Nguyen, P. L., & Bouwstra, J. A. (2005) · Drug Discovery Today: Technologies · doi:10.1016/j.ddtec.2005.05.003 · Cited by 365
Self-citationPig and guinea pig skin as surrogates for human in vitro penetration studies: A quantitative review
Barbero, A. M., & Frasch, H. F. (2009) · Toxicology in Vitro · doi:10.1016/j.tiv.2008.10.008 · Cited by 351
Marjukka Suhonen, T., A. Bouwstra, J., & Urtti, A. (1999) · Journal of Controlled Release · doi:10.1016/s0168-3659(98)00187-4 · Cited by 310
Bouwstra, J. A., Gooris, G. S., Dubbelaar, F. E. R., & Ponec, M. (2002) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2002.01706.x · Cited by 165
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Metadata
- Authors
- Bouwstra, J. A., Gooris, G. S., Bras, W., & Downing, D. T.
- Venue
- Journal of Lipid Research
- Publisher
- Elsevier BV
- Published
- 1995-04
- Volume
- 36
- Issue
- 4
- Pages
- 685-695
- ISSN
- 0022-2275 (ISSN-L)
- OpenAlex
- W2321278656
- Cited by
- 208
- References
- 0
- FWCI
- 2.49
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Bouwstra, J. A., Gooris, G. S., Bras, W., & Downing, D. T. (1995). Lipid organization in pig stratum corneum. Journal of Lipid Research. https://doi.org/10.1016/s0022-2275(20)40054-9
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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