The DOI matches its Crossref record; 218 of the 218 references it cites were found in a registry or an index.
In vivo regulation of lipolysis in humans.
Open accessAbstract
Fatty acids are important oxidative fuel for liver, kidney, skeletal muscle, and myocardium. There has been much interest in the role of fatty acids in the pathogenesis of non-insulin-dependent diabetes because they compete with glucose for oxygen and inhibit whole body glucose disposal via the 'Randle cycle,' Control of lipolysis in adipose tissue determines systemic fatty acid supply. A wide range of hormones and other substances have been recognized as regulators of lipolysis, but insulin and catecholamines appear to be the most important. The regulation of lipolysis, in most circumstances, provides a supply of lipid fuel exceeding the rate of lipid oxidation, requiring reesterification to triglyceride of surplus circulating free fatty acids. Thus, free fatty acid supply is usually not matched to the demand for lipid oxidation, and there is no known mechanism for accurately sensing such demand. This lax regulation may be disadvantageous in conditions such as aging, stress, obesity, and diabetes, where the antilipolytic effect of insulin is impaired and lipolysis is therefore increased. In these conditions, the surfeit of fatty acid may impair glucoregulation. In addition, the excess lipolysis may induce hypertriglyceridemia (via increased very low density lipoprotein production) and thus contribute to atherogenesis. Considerable additional research is needed in order to fully understand both normal lipolytic regulation and the abnormalities of lipolysis which accompany pathological conditions.
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Cites
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Cited by
Cornier, M.-A., Dabelea, D., Hernandez, T. L., Lindstrom, R. C., Steig, A. J., Stob, N. R., Van Pelt, R. E., Wang, H., & Eckel, R. H. (2008) · Endocrine Reviews · doi:10.1210/er.2008-0024 · Cited by 2,162
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Lipolysis and lipid mobilization in human adipose tissue
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The role of lipid droplets in metabolic disease in rodents and humans
Greenberg, A. S., Coleman, R. A., Kraemer, F. B., McManaman, J. L., Obin, M. S., Puri, V., Yan, Q.-W., Miyoshi, H., & Mashek, D. G. (2011) · Journal of Clinical Investigation · doi:10.1172/jci46069 · Cited by 621
Haemmerle, G., Zimmermann, R., Hayn, M., Theussl, C., Waeg, G., Wagner, E., Sattler, W., Magin, T. M., Wagner, E. F., & Zechner, R. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m110355200 · Cited by 613
Metadata
- Authors
- Coppack, S. W., Jensen, M. D., & Miles, J. M.
- Venue
- Journal of Lipid Research
- Publisher
- Elsevier BV
- Published
- 1994-02
- Volume
- 35
- Issue
- 2
- Pages
- 177-193
- ISSN
- 0022-2275 (ISSN-L)
- OpenAlex
- W1823480916
- Cited by
- 407
- References
- 218
- FWCI
- 7.46
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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