The DOI matches its Crossref record.
Lipid and protein structures in the permeability barrier of mammalian epidermis.
Open accessAbstract
The epidermis of terrestrial vertebrates has evolved to provide a barrier to water permeation that is essential for survival in a desiccating environment. It has been realized for decades that this barrier is provided by lipids, but it was only during the 1980s that the molecular structure and physical arrangement of these lipids were defined. During the past several years, it has become apparent that in the performance of their function, epidermal lipids interact with proteins, and in some instances are covalently linked to protein structures. It is the purpose of this review to inspect and evaluate those instances where lipids and proteins interact in providing the epidermal barrier. For the benefit of those whose experience does not include dermatology, it will be desirable to briefly review the macroscopic and microscopic anatomy of the skin, as well as the biochemistry of the epidermal lipids.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Claudin-based tight junctions are crucial for the mammalian epidermal barrier
Furuse, M., Hata, M., Furuse, K., Yoshida, Y., Haratake, A., Sugitani, Y., Noda, T., Kubo, A., & Tsukita, S. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200110122 · Cited by 1,512
Klf4 is a transcription factor required for establishing the barrier function of the skin
Segre, J. A., Bauer, C., & Fuchs, E. (1999) · Nature Genetics · doi:10.1038/11926 · Cited by 788
The skin barrier in healthy and diseased state
Bouwstra, J. A., & Ponec, M. (2006) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2006.06.021 · Cited by 666
Bricks and mortar of the epidermal barrier
Nemes, Z., & Steinert, P. M. (1999) · Experimental & Molecular Medicine · doi:10.1038/emm.1999.2 · Cited by 567
The important role of stratum corneum lipids for the cutaneous barrier function
van Smeden, J., Janssens, M., Gooris, G. S., & Bouwstra, J. A. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2013.11.006 · Cited by 549
Metadata
- Authors
- Downing, D.
- Venue
- Journal of Lipid Research
- Publisher
- Elsevier BV
- Published
- 1992-03
- Volume
- 33
- Issue
- 3
- Pages
- 301-313
- ISSN
- 0022-2275 (ISSN-L)
- OpenAlex
- W2129471415
- Cited by
- 315
- References
- 0
- FWCI
- 3.94
- Type
- journal article
- Language
- en
- Open access
- hybrid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Lipid and protein structures in the permeability barrier of mammalian epidermis. https://app.cochat.ai/papers/10.1016/s0022-2275(20)41520-2
- The paper
- Downing, D. (1992). Lipid and protein structures in the permeability barrier of mammalian epidermis. Journal of Lipid Research. https://doi.org/10.1016/s0022-2275(20)41520-2
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
