The important role of stratum corneum lipids for the cutaneous barrier function
Abstract
The skin protects the body from unwanted influences from the environment as well as excessive water loss. The barrier function of the skin is located in the stratum corneum (SC). The SC consists of corneocytes embedded in a lipid matrix. This lipid matrix is crucial for the lipid skin barrier function. This paper provides an overview of the reported SC lipid composition and organization mainly focusing on healthy and diseased human skin. In addition, an overview is provided on the data describing the relation between lipid modulations and the impaired skin barrier function. Finally, the use of in vitro lipid models for a better understanding of the relation between the lipid composition, lipid organization and skin lipid barrier is discussed. This article is part of a Special Issue entitled The Important Role of Lipids in the Epidermis and their Role in the Formation and Maintenance of the Cutaneous Barrier. This article is part of a Special Issue entitled The Important Role of Lipids in the Epidermis and their Role in the Formation and Maintenance of the Cutaneous Barrier. Guest Editors: Kenneth R. Feingold and Peter Elias.
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The symptoms of fatty acid deficiency include dryness of the epidermis, peeling, flabby skin, skin inflammation, an increased susceptibility to irritation and slower healing.
“The symptoms of fatty acid deficiency include dryness of the epidermis, peeling, flabby skin, skin inflammation, an increased susceptibility to irritation and slower healing.”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [159]
Many skin problems, including excessive exfoliation of the epidermis, are caused by a deficiency of GLA.
“Many skin problems, including excessive exfoliation of the epidermis, are also caused by a deficiency of GLA, which is formed from LA via an enzymatic reaction involving delta-6 desaturase [153,154,158,159].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [159]
A deficiency of linoleic acid, a component of ceramide 1, results in the dysfunction of the skin barrier and symptoms of dry skin.
“A deficiency of LA, a component of ceramide 1, which plays an important role in the cohesiveness of the intracellular cement, results in the dysfunction of the skin barrier and symptoms of dry skin.”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [159]
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- Authors
- van Smeden, J., Janssens, M., Gooris, G. S., & Bouwstra, J. A.
- Affiliations
- Leiden University (NL)
- Corresponding author
- Bouwstra, J.A.
- ORCID
- Bouwstra, J.A.
- Venue
- Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
- Publisher
- Elsevier BV
- Published
- 2014-03
- Volume
- 1841
- Issue
- 3
- Pages
- 295-313
- ISSN
- 1388-1981 (ISSN-L)
- OpenAlex
- W1993882354
- Cited by
- 549
- References
- 174
- Citations by year
- 2026: 27 · 2025: 30 · 2024: 42 · 2023: 40 · 2022: 48 · 2021: 58 · 2020: 51 · 2019: 58 · 2018: 52 · 2017: 52 · 2016: 41 · 2015: 33 · 2014: 16 · 2013: 1
- FWCI
- 3.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Health Sciences › Medicine › Dermatology › Contact Dermatitis and Allergies
- Keywords
- stratum corneum lipids, skin barrier function, lipid matrix, corneocytes, lipid composition, lipid organization, epidermal lipids, skin diseases
- MeSH terms
- Animals, Epidermis, Humans, Lipids, Models, Chemical, Skin Diseases, Water-Electrolyte Balance, Lipid Metabolism
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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