The DOI matches its Crossref record; 25 of the 26 references it cites were found in a registry or an index.
Impaired natural killer activity in lymphohistiocytosis syndrome
Abstract
In six patients with well-documented lymphohistiocytosis syndrome, natural killer activity was found to be profoundly impaired and could not be increased by incubation in vitro with interferon. This abnormality was not found in parents of the affected children. A clear correlation with the activity of the disease was observed, although a delay of a few weeks (possibly reflecting the life span of NK cells in blood) was seen in the disappearance of NK activity after the onset of the disease and its reappearance after remission. No absolute correlation was observed between NK activity and percentage of leukocytes detected by the Leu-7 monoclonal antibody. Our findings indicate that testing NK activity is useful for the diagnosis of lymphohistiocytosis syndrome and can be used as an index of activity of the disease, among other major clinical and biologic signs of this syndrome. Reversal of the NK activity defect (rather than detection of Leu-7 positive cells) appears to be a good criterion of complete remission.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The cytolytic function of NK cells is diminished in some forms of cytokine storm, which can lead to prolonged antigenic stimulation and difficulty resolving inflammation.”
From Cytokine storm (2020) · cites this paper as [17]
Citations
Cites
A differentiation antigen of human NK and K cells identified by a monoclonal antibody (HNK-1).
Abo, T., & Balch, C. M. (1981) · The Journal of Immunology · doi:10.4049/jimmunol.127.3.1024 · Cited by 1,407
The Primary Immunodeficiencies
Rosen, F. S., Cooper, M. D., & WEDGWOOD, R. J. P. (1984) · New England Journal of Medicine · doi:10.1056/nejm198408023110506 · Cited by 1,097
Risdall, R. J., McKenna, R. W., Nesbit, M. E., Krivit, W. A., Balfour, H. H., Simmons, R. L., & Brunning, R. D. (1979) · Cancer · doi:10.1002/1097-0142(197909)44:3 · Cited by 1,037
The Chediak-Higashi syndrome: studies in four patients and a review of the literature.
BLUME, R. S., & Wolff, S. M. (1972) · PubMed · Cited by 397
A syndrome associating partial albinism and immunodeficiency
Griscelli, C., Durandy, A., Guy‐Grand, D., Daguillard, F., Herzog, C., & PRUNIERAS, M. (1978) · The American Journal of Medicine · doi:10.1016/0002-9343(78)90858-6 · Cited by 384
Self-citationBLUME, R. S., & Wolff, S. M. (1972) · Medicine · doi:10.1097/00005792-197207000-00001 · Cited by 330
The Primary Immunodeficiencies
Rosen, F. S., Cooper, M. D., & WEDGWOOD, R. J. P. (1984) · New England Journal of Medicine · doi:10.1056/nejm198407263110406 · Cited by 291
A new immunodeficiency disorder in humans involving NK cells
Roder, J., Haliotis, T. P., Klein, M., Korec, S., Jett, J. R., Ortaldo, J. R., Heberman, R. B., Katz, P., & Fauci, A. S. (1980) · Nature · doi:10.1038/284553a0 · Cited by 277
Virus associated hemophagocytic syndrome
McKenna, R. W., Risdall, R. J., & Brunning, R. D. (1981) · Human Pathology · doi:10.1016/s0046-8177(81)80019-6 · Cited by 263
Generation of natural killer cells: an autonomous function of the bone marrow.
Haller, O., Kiessling, R. W., Örn, A., & Wigzell, H. (1977) · The Journal of Experimental Medicine · doi:10.1084/jem.145.5.1411 · Cited by 191
Research works printed but not linked: 3
- Mozziconacci, 1965, La lymphohistiocytose familiale, Arch Fr Pediatr, 22, 385
- Devictor, 1982, Etude immunologique de la lymphohistiocytose familiale, Arch Fr Pediatr, 39, 135
- Virelizier, 1981, D?faut s?lectif de s?cr?tion d'interferon associ? ? un d?ficit d'activit? cytoxique naturelle, Arch Fr Pediatr, 38, 77
Cited by
Sorted by citations
HLH‐2004: Diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis
Henter, J., Horne, A., Aricò, M., Egeler, R. M., Filipovich, A. H., Imashuku, S., Ladisch, S., McClain, K. L., Webb, D. K. H., Winiarski, J. H., et al. (2006) · Pediatric Blood & Cancer · doi:10.1002/pbc.21039 · Cited by 5,396
“This causes the defect in the NK and T-cell cytotoxicity that has been recognized for long [15,16],with three causativegene defects known today; PRF [9], UNC13D [40], and STX11 [41].”
BackgroundFajgenbaum, D. C., & June, C. H. (2020) · New England Journal of Medicine · doi:10.1056/nejmra2026131 · Cited by 3,196
Familial hemophagocytic lymphohistiocytosis
Janka, G. (1983) · European Journal of Pediatrics · doi:10.1007/bf00443367 · Cited by 576
Masera, G., Chesler, M. A., Jankovic, M., Ablin, A. R., Arush, M. W. B., Breatnach, F., McDowell, H. P., Eden, T. O. B., Epelman, C. L., Bellani, F. F., et al. (1997) · Medical and Pediatric Oncology · doi:10.1002/(sici)1096-911x(199705)28:5 · Cited by 71
Familial and acquired hemophagocytic lymphohistiocytosis
Janka, G. (2006) · European Journal of Pediatrics · doi:10.1007/s00431-006-0258-1 · Cited by 534
“A hallmark of HLH, in genetic as well as in acquired cases, is impaired or absent function of natural killer (NK) cells and cytotoxic T lymphocytes (CTL) measured as lysis of K652 cells in a standard 4h chromium release assay [5, 17, 88, 102, 112].”
Background
Metadata
- Authors
- Perez, N., Virelizier, J.-L., Arenzana-Seisdedos, F., Fischer, A., & Griscelli, C.
- ORCID
- Fischer, Alain
- Venue
- The Journal of Pediatrics
- Publisher
- Elsevier BV
- Published
- 1984-04
- Volume
- 104
- Issue
- 4
- Pages
- 569-573
- ISSN
- 0022-3476 (ISSN-L)
- OpenAlex
- W2059566117
- Cited by
- 121
- References
- 26
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 2 · 2022: 2 · 2021: 5 · 2020: 1 · 2019: 2 · 2018: 3 · 2017: 1 · 2016: 2 · 2015: 1 · 2014: 1 · 2013: 3 · 2012: 3
- FWCI
- 1.17
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Pediatrics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immunodeficiency and Autoimmune Disorders
- Life Sciences › Immunology and Microbiology › Immunology › Immune Cell Function and Interaction
- Health Sciences › Medicine › Hematology › Autoimmune and Inflammatory Disorders Research
- Keywords
- natural killer cells, NK cell dysfunction, interferon, disease activity monitoring, remission, NK cell depletion
- MeSH terms
- Antibodies, Monoclonal, Cytotoxicity, Immunologic, Fluorescent Antibody Technique, Humans, Killer Cells, Natural, Leukocytes, Lymphatic Diseases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
