Fischer, Alain

LMO2 -Associated Clonal T Cell Proliferation in Two Patients after Gene Therapy for SCID-X1

Hacein-Bey-Abina, S., Von Kalle, C., Schmidt, M., McCormack, M. P., Wulffraat, N., Leboulch, P., Lim, A., Osborne, C. S., Pawliuk, R., Morillon, E., et al. (2003) · Science

Virus-based gene therapy researchCAR-T cell therapy research

Cited by 3,587

Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients

Hadjadj, J., Yatim, N., Barnabei, L., Corneau, A., Boussier, J., Smith, N., Péré, H., Charbit, B., Bondet, V., Chenevier-Gobeaux, C., et al. (2020) · Science

interferon and immune responsesCOVID-19 Clinical Research Studies

Cited by 2,984

A serious adverse event after successful gene therapy for X-linked severe combined immunodeficiency

Hacein-Bey-Abina, S., von Kalle, C., Schmidt, M., Le Deist, F., Wulffraat, N., McIntyre, E., Radford, I., Villeval, J.-L., Fraser, C. C., Cavazzana-Calvo, M., et al. (2003) · New England Journal of Medicine

Virus-based gene therapy researchImmunodeficiency and Autoimmune Disorders

Cited by 1,867

Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1

Hacein-Bey-Abina, S., Garrigue, A., Wang, G. P., Soulier, J., Lim, A., Morillon, E., Clappier, E., Caccavelli, L., Delabesse, E., Beldjord, K., et al. (2008) · Journal of Clinical Investigation

Virus-based gene therapy researchCAR-T cell therapy research

Cited by 1,854

Hematopoietic Stem Cell Gene Therapy with a Lentiviral Vector in X-Linked Adrenoleukodystrophy

Cartier, N., Hacein-Bey-Abina, S., Bartholomae, C. C., Veres, G., Schmidt, M., Kutschera, I., Vidaud, M., Abel, U., Dal-Cortivo, L., Caccavelli, L., et al. (2009) · Science

Virus-based gene therapy researchLysosomal Storage Disorders Research

Cited by 1,508

Transfusion independence and HMGA2 activation after gene therapy of human β-thalassaemia

Cavazzana-Calvo, M., Payen, E., Negre, O., Wang, G., Hehir, K., Fusil, F., Down, J., Denaro, M., Brady, T., Westerman, K., et al. (2010) · Nature

Virus-based gene therapy researchHemoglobinopathies and Related Disorders

Cited by 1,276

Cernunnos, a Novel Nonhomologous End-Joining Factor, Is Mutated in Human Immunodeficiency with Microcephaly

Buck, D., Malivert, L., de Chasseval, R., Barraud, A., Fondanèche, M.-C., Sanal, O., Plebani, A., Stéphan, J.-L., Hufnagel, M., le Deist, F., et al. (2006) · Cell

DNA Repair MechanismsImmunodeficiency and Autoimmune Disorders

Cited by 722

The European society for immunodeficiencies (ESID) registry working definitions for the clinical diagnosis of inborn errors of immunity

Seidel, M. G., Kindle, G., Gathmann, B., Quinti, I., Buckland, M., van Montfrans, J., Scheible, R., Rusch, S., Gasteiger, L. M., Grimbacher, B., et al. (2019) · The Journal of Allergy and Clinical Immunology In Practice

Immunodeficiency and Autoimmune DisordersBlood disorders and treatments

Cited by 647

Inherited STING-activating mutation underlies a familial inflammatory syndrome with lupus-like manifestations

Jeremiah, N., Neven, B., Gentili, M., Callebaut, I., Maschalidi, S., Stolzenberg, M.-C., Goudin, N., Frémond, M.-L., Nitschke, P., Molina, T. J., et al. (2014) · Journal of Clinical Investigation

interferon and immune responsesSystemic Lupus Erythematosus Research

Cited by 562

Pearson's marrow–pancreas syndrome. A multisystem mitochondrial disorder in infancy

Rötig, A., Cormier, V, Blanche, S., Bonnefont, J. P., Ledeist, F., Romero, N., Schmitz, J., Rustin, P., Fischer, A., & Saudubray, J. M. (1990) · Journal of Clinical Investigation

Mitochondrial Function and PathologyMetabolism and Genetic Disorders

Cited by 461

A Modified γ-Retrovirus Vector for X-Linked Severe Combined Immunodeficiency

Hacein-Bey-Abina, S., Pai, S.-Y., Gaspar, H. B., Armant, M., Berry, C. C., Blanche, S., Bleesing, J., Blondeau, J., de Boer, H., Buckland, K. F., et al. (2014) · New England Journal of Medicine

Virus-based gene therapy researchImmunodeficiency and Autoimmune Disorders

Cited by 412

Reversal of Early Neurologic and Neuroradiologic Manifestations of X-Linked Adrenoleukodystrophy by Bone Marrow Transplantation

Aubourg, P., Blanche, S., Jambaqué, I., Rocchiccioli, F., Kalifa, G., Naud-Saudreau, C., Rolland, M.-O., Debré, M., Chaussain, J.-L., Griscelli, C., et al. (1990) · New England Journal of Medicine

Metabolism and Genetic DisordersLysosomal Storage Disorders Research

Cited by 366

Long-term effect of bone-marrow transplantation for childhood-onset cerebral X-linked adrenoleukodystrophy

Shapiro, E., Krivit, W., Lockman, L., Jambaqué, I., Peters, C., Cowan, M., Harris, R., Blanche, S., Bordigoni, P., Loes, D., et al. (2000) · The Lancet

Metabolism and Genetic DisordersLysosomal Storage Disorders Research

Cited by 329

Inflammasome activation in nadph oxidase defective mononuclear phagocytes from patients with chronic granulomatous disease

Meissner, F., Seger, R. A., Moshous, D., Fischer, A., Reichenbach, J., & Zychlinsky, A. (2010) · Blood

Inflammasome and immune disordersNeutrophil, Myeloperoxidase and Oxidative Mechanisms

Cited by 269

Severe combined immunodeficiency caused by deficiency in either the δ or the ε subunit of CD3

Basile, G. D. S., Geissmann, F., Flori, E., Uring-Lambert, B., Soudais, C., Cavazzana-Calvo, M., Durandy, A., Jabado, N., Fischer, A., & Deist, F. L. (2004) · Journal of Clinical Investigation

Immunodeficiency and Autoimmune DisordersT-cell and B-cell Immunology

Cited by 171

Dominant-negative IKZF1 mutations cause a T, B, and myeloid cell combined immunodeficiency

Boutboul, D., Kuehn, H. S., Van de Wyngaert, Z., Niemela, J. E., Callebaut, I., Stoddard, J., Lenoir, C., Barlogis, V., Farnarier, C., Vely, F., et al. (2018) · Journal of Clinical Investigation

Immunodeficiency and Autoimmune DisordersT-cell and B-cell Immunology

Cited by 169

Early-onset autoimmunity associated with SOCS1 haploinsufficiency

Hadjadj, J., Castro, C. N., Tusseau, M., Stolzenberg, M.-C., Mazerolles, F., Aladjidi, N., Armstrong, M., Ashrafian, H., Cutcutache, I., Ebetsberger-Dachs, G., et al. (2020) · Nature Communications

Cytokine Signaling Pathways and InteractionsImmunodeficiency and Autoimmune Disorders

Cited by 156

Survival and Functional Outcomes in Boys with Cerebral Adrenoleukodystrophy with and without Hematopoietic Stem Cell Transplantation

Raymond, G. V., Aubourg, P., Paker, A., Escolar, M., Fischer, A., Blanche, S., Baruchel, A., Dalle, J.-H., Michel, G., Prasad, V., et al. (2019) · Biology of Blood and Marrow Transplantation

Metabolism and Genetic DisordersLysosomal Storage Disorders Research

Cited by 142

Cernunnos Interacts with the XRCC4·DNA-ligase IV Complex and Is Homologous to the Yeast Nonhomologous End-joining Factor Nej1

Callebaut, I., Malivert, L., Fischer, A., Mornon, J.-P., Revy, P., & de Villartay, J.-P. (2006) · Journal of Biological Chemistry

DNA Repair MechanismsCRISPR and Genetic Engineering

Cited by 130

Lentiviral Hematopoietic Cell Gene Therapy for X-Linked Adrenoleukodystrophy

Cartier, N., Hacein-Bey-Abina, S., Bartholomae, C. C., Bougnères, P., Schmidt, M., Von Kalle, C., Fischer, A., Cavazzana-Calvo, M., & Aubourg, P. (2012) · Methods in Enzymology

Virus-based gene therapy researchLysosomal Storage Disorders Research

Cited by 123

Impaired natural killer activity in lymphohistiocytosis syndrome

Perez, N., Virelizier, J.-L., Arenzana-Seisdedos, F., Fischer, A., & Griscelli, C. (1984) · The Journal of Pediatrics

Immunodeficiency and Autoimmune DisordersImmune Cell Function and Interaction

Cited by 121