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Cited by 96Growth Hormone and Insulin-like Growth FactorsPituitary Gland Disorders and TreatmentsHypothalamic control of reproductive hormones

Evaluation of growth hormone release and human growth hormone treatment in children with cranial irradiation-associated short stature

Romshe, Carolyn A., Zipf, William B., Miser, Angela, Miser, James, Sotos, Juan F., Newton, William A.·1984·The Journal of Pediatrics
DOI 10.1016/s0022-3476(84)80988-9
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Abstract

We studied nine children who had received cranial irradiation for various malignancies and subsequently experienced decreased growth velocity. Their response to standard growth hormone stimulation and release tests were compared with that in seven children with classic GH deficiency and in 24 short normal control subjects. With arginine and L-dopa stimulation, six of nine patients who received radiation had a normal GH response (greater than 7 ng/ml), whereas by design none of the GH deficient and all of the normal children had a positive response. Only two of nine patients had a normal response to insulin hypoglycemia, with no significant differences in the mean maximal response of the radiation and the GH-deficient groups. Pulsatile secretion was not significantly different in the radiation and GH-deficient groups, but was different in the radiation and normal groups. All subjects in the GH-deficient and radiation groups were given human growth hormone for 1 year. Growth velocity increased in all, with no significant difference in the response of the two groups when comparing the z scores for growth velocity of each subject's bone age. We recommend a 6-month trial of hGH in children who have had cranial radiation and are in prolonged remission with a decreased growth velocity, as there is no completely reliable combination of GH stimulation or release tests to determine their response.

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Crossref · 10.1016/s0022-3476(84)80988-9

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  • GH stimulation tests identify children and adults who have clear-cut GHD but may miss persons with partial GHD.

    “GH stimulation tests identify children and adults who have clear–cut GHD but may miss persons with partial GHD [53].”

    From Update of Endocrine Dysfunction following Pediatric Traumatic Brain Injury (2015) · cites this paper as [53]

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Authors
Romshe, C. A., Zipf, W. B., Miser, A., Miser, J., Sotos, J. F., & Newton, W. A.
Corresponding author
Romshe, Carolyn A.
ORCID
Miser, James
Venue
The Journal of Pediatrics
Publisher
Elsevier BV
Published
1984-02
Volume
104
Issue
2
Pages
177-181
ISSN
0022-3476 (ISSN-L)
DOI
10.1016/s0022-3476(84)80988-9
OpenAlex
W2056309567
Cited by
96
References
24
Citations by year
2021: 1 · 2015: 3
FWCI
7.88
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • The Journal of Pediatrics (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords
cranial irradiation, short stature, growth hormone therapy, growth hormone deficiency, growth hormone stimulation test, pulsatile growth hormone secretion, arginine stimulation, growth rate, childhood cancer survivors, bone age
MeSH terms
Adolescent, Brain, Brain Neoplasms, Child, Child, Preschool, Female, Growth Disorders, Humans, Leukemia, Lymphoid, Male, Radiation Injuries, Growth Hormone

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