β-Adrenergic Relaxation of Rabbit Tracheal Smooth Muscle: A Receptor Deficit That Improves with Corticosteroid Administration
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Cortisol and norepinephrine cooperate at a molecular level, and this permissive effect of cortisol is due to beta adrenoceptor up regulation and stabilisation of the cAMP/protein kinase A/CREB signalling pathway.
“This permissive effect of cortisol is due to b adrenoceptor up regulation and stabilisation of the cyclic AMP (cAMP)/protein kinase A/ cAMP responsive element binding protein signalling pathway.30”
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- Authors
- Schramm, C. M.
- Corresponding author
- Schramm, Craig M.
- ORCID
- Schramm, Craig M.
- Venue
- The Journal of Pharmacology and Experimental Therapeutics
- Publisher
- Elsevier BV
- Published
- 2000-02
- Volume
- 292
- Issue
- 1
- Pages
- 280-287
- ISSN
- 0022-3565 (ISSN-L)
- OpenAlex
- W4406066099
- Cited by
- 11
- References
- 36
- Citations by year
- 2014: 1
- FWCI
- 0.36
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Pharmacology and Experimental Therapeutics (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- beta-adrenergic receptors, tracheal smooth muscle, airway relaxation, corticosteroids, airway hyperresponsiveness, rabbits
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