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Cited by 209Cardiac electrophysiology and arrhythmiasIon channel regulation and functionCardiac Arrhythmias and Treatments

The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.

Gender Difference in the Cycle Length-Dependent QT and Potassium Currents in Rabbits

Liu, Xiao-Ke, Katchman, Alexander, Drici, Milou-Daniel, Ebert, Steven N., Ducic, Ivan, Morad, Martin, Woosley, Raymond L.·1998·The Journal of Pharmacology and Experimental Therapeutics
DOI 10.1016/s0022-3565(24)37435-x
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Abstract

Women are known to have a longer electrocardiographic Q-T than men, which may contribute to their being at greater risk of developing drug-induced polymorphic ventricular arrhythmias. However, little is known about the underlying mechanisms. In the present study, we evaluated potential gender differences in Q-T interval in isolated perfused rabbit hearts using the Langendorff technique and evaluated the density of outward potassium currents in single ventricular myocytes using the whole-cell patch-clamp technique. We found that female hearts demonstrated a greater Q-T lengthening (delta Q-T%) upon an increase in cycle length (CL), resulting in a significantly longer Q-T (301 +/- 4.8 ms, CL = 2.3 s) at a long CL in female hearts compared with male hearts (267 +/- 4.0 ms, P < .01). Ventricular myocytes isolated from female hearts showed a smaller IK(tail) and peak IKI outward current density. A 50% reduction in extracellular K+ and Mg++ shifted the I-V relationship of IKI and Ito and reduced their amplitude. However, neither the I-V relationship of IKr nor the gender difference in the Q-T-CL relationship was significantly altered. We conclude that 1) female rabbit ventricular myocytes have significantly lower IKr and IKl outward current densities than do male cells, which may contribute to the gender difference in Q-T, and 2) a lower base-line IKr density may contribute to the steeper Q-T-CL relationship in female hearts.

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Crossref · 10.1016/s0022-3565(24)37435-x

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Research works printed but not linked: 4

  1. Dessertenne, 1966, La tachycardie ventriculaire à deux foyers opposés variables., Arch Mal Coeur, 59, 263
  2. Knollmann, 1996, Acute effects of 17-β estradiol and dihydrotesterone on action potential duration and QT-interval in isolated rabbit hearts (Abstract)., J Investigative Med, 44, 209A
  3. Liu, 1997, Female gender is a risk factor for torsades de pointes in an in vitro animal model (Abstract)., Circulation, 96, I-555
  4. Nuss, 1997, HERG overexpression in cultured adult ventricular myocytes hastens repolarization and suppresses early afterdepolarization (Abstract)., Circulation, 98, I-7

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Metadata

Authors
Liu, X.-K., Katchman, A., Drici, M.-D., Ebert, S. N., Ducic, I., Morad, M., & Woosley, R. L.
Affiliations
Georgetown University Medical Center (US)
ORCID
Venue
The Journal of Pharmacology and Experimental Therapeutics
Publisher
Elsevier BV
Published
1998-05
Volume
285
Issue
2
Pages
672-679
ISSN
0022-3565 (ISSN-L)
DOI
10.1016/s0022-3565(24)37435-x
OpenAlex
W2210759123
Cited by
209
References
29
Citations by year
2026: 3 · 2025: 3 · 2023: 3 · 2022: 6 · 2021: 4 · 2020: 6 · 2019: 6 · 2018: 3 · 2017: 2 · 2016: 5 · 2015: 9 · 2014: 4 · 2013: 13 · 2012: 7
FWCI
7.06
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Journal of Pharmacology and Experimental Therapeutics (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed
Funders
  • National Institutes of Health (5r01hl054590-05)
  • National Heart, Lung, and Blood Institute (R01 HL54590)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Arrhythmias and Treatments
Keywords
gender differences, QT interval, cycle length, outward potassium current, IKr, inward rectifier potassium current, ventricular myocytes, ventricular repolarization, extracellular potassium, extracellular magnesium, drug-induced ventricular arrhythmia, rabbit heart
MeSH terms
Animals, Electrocardiography, Female, Magnesium, Male, Potassium, Rabbits, Sex Factors, Potassium Channels

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