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A METHOD FOR DETERMINING LOSS OF PAIN SENSATION
Abstract
1. A simple, rapid method for determining the pain threshold in the rat is described. 2. The individual variation, under a variety of conditions, was found to be surprisingly small. 3. The method was applied to the determination of analgesic properties of several substances, including cobra venom. No analgesic property in the latter could be demonstrated. 4. A comparative assay of five opiates gave results in good agreement with clinical experience.
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Citations
Cited by
Intrathecal morphine in mice: A new technique
Hylden, J. L. K., & Wilcox, G. L. (1980) · European Journal of Pharmacology · doi:10.1016/0014-2999(80)90515-4 · Cited by 1,922
Le Bars, D., Gozariu, M., & Cadden, S. W. (2001) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01514-x · Cited by 1,459
Heritability of nociception I: Responses of 11 inbred mouse strains on 12 measures of nociception
Mogil, J. S., Wilson, S. G., Bon, K., Eun Lee, S., Chung, K., Raber, P., Pieper, J. O., Hain, H. S., Belknap, J. K., Hubert, L., et al. (1999) · Pain · doi:10.1016/s0304-3959(98)00197-3 · Cited by 656
DeWire, S. M., Yamashita, D. S., Rominger, D. H., Liu, G., Cowan, C. L., Graczyk, T. M., Chen, X.-T., Pitis, P. M., Gotchev, D., Yuan, C., et al. (2013) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.112.201616 · Cited by 647
Bupropion is a nicotinic antagonist
Slemmer, J. E., Martin, B. R., & Damaj, M. I. (2000) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)38905-0 · Cited by 509
Metadata
- Authors
- D'AMOUR, F. E., & SMITH, D. L.
- Venue
- The Journal of Pharmacology and Experimental Therapeutics
- Publisher
- Elsevier BV
- Published
- 1941-05
- Volume
- 72
- Issue
- 1
- Pages
- 74-79
- ISSN
- 0022-3565 (ISSN-L)
- OpenAlex
- W2206043426
- Cited by
- 3,231
- References
- 0
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
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- CoChat. (2026). Citation check: A METHOD FOR DETERMINING LOSS OF PAIN SENSATION. https://app.cochat.ai/papers/10.1016/s0022-3565(25)03823-6
- The paper
- D'AMOUR, F. E., & SMITH, D. L. (1941). A METHOD FOR DETERMINING LOSS OF PAIN SENSATION. The Journal of Pharmacology and Experimental Therapeutics. https://doi.org/10.1016/s0022-3565(25)03823-6
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.