Animal models of nociception

Ethical guidelines for investigations of experimental pain in conscious animals.

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A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man

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A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia

Hargreaves, K., Dubner, R. A., Brown, F. J., Flores, C., & Joris, J. L. (1988) · Pain · doi:10.1016/0304-3959(88)90026-7 · Cited by 5,155 · see citing works

A METHOD FOR DETERMINING LOSS OF PAIN SENSATION

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An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat

Ho Kim, S., & Mo Chung, J. (1992) · Pain · doi:10.1016/0304-3959(92)90041-9 · Cited by 3,069 · see citing works

The formalin test: A quantitative study of the analgesic effects of morphine, meperidine, and brain stem stimulation in rats and cats

Dubuisson, D., & Dennis, S. G. (1977) · Pain · doi:10.1016/0304-3959(77)90130-0 · Cited by 2,534 · see citing works

The formalin test: an evaluation of the method

Tjølsen, A., Berge, O., Hunskaar, S., Rosland, J. H., & Hole, K. (1992) · Pain · doi:10.1016/0304-3959(92)90003-t · Cited by 2,434 · see citing works

Advances in Pain Research and Therapy

Wang, J. K. (1980) · Anesthesia & Analgesia · doi:10.1213/00000539-198002000-00022 · Cited by 2,263 · see citing works

The formalin test in mice: dissociation between inflammatory and non-inflammatory pain

Hunskaar, S., & Hole, K. (1987) · Pain · doi:10.1016/0304-3959(87)90088-1 · Cited by 2,191 · see citing works

ACETIC ACID FOR ANALGESIC SCREENING

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Habituation: a dual-process theory.

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Vanilloid (Capsaicin) Receptors and Mechanisms

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Capsaicin: cellular targets, mechanisms of action, and selectivity for thin sensory neurons.

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SYNTHETIC ANALGESICS. II. DITHIENYLBUTENYL- AND DITHIENYLBUTYLAMINES

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New Developments in Electromyography and Clinical Neurophysiology.

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A method for measurement of analgesic activity on inflamed tissue.

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Flexion‐reflex of the limb, crossed extension‐reflex, and reflex stepping and standing

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THE ABDOMINAL CONSTRICTION RESPONSE AND ITS SUPPRESSION BY ANALGESIC DRUGS IN THE MOUSE

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Opioid and nonopioid components independently contribute to the mechanism of action of tramadol, an 'atypical' opioid analgesic.

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Characterization of a rat model of incisional pain

Brennan, T. J., Vandermeulen, E., & Gebhart, G. F. (1996) · Pain · doi:10.1016/0304-3959(95)01441-1 · Cited by 1,101 · see citing works

Pain measurement: an overview

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THE EVALUATION OF THE ANALGESIC ACTION OF PETHIDINE HYDROCHLORIDE (DEMEROL)

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Guidelines on the recognition of pain, distress and discomfort in experimental animals and an hypothesis for assessment

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Advances in Pain Research and Therapy

Carron, H. (1985) · Anesthesiology · doi:10.1097/00000542-198501000-00033 · Cited by 966 · see citing works

Modified formalin test: characteristic biphasic pain response

Shibata, M., Ohkubo, T., Takahashi, H., & Inoki, R. (1989) · Pain · doi:10.1016/0304-3959(89)90222-4 · Cited by 955 · see citing works

The Integrative Action of the Nervous System.

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Functional characteristics of the midbrain periaqueductal gray.

Behbehani, M. M. (1995) · Progress in Neurobiology · doi:10.1016/0301-0082(95)00009-k · Cited by 879 · see citing works

Formalin test in mice, a useful technique for evaluating mild analgesics

Hunskaar, S., Fasmer, O. B., & Hole, K. (1985) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(85)90116-5 · Cited by 825 · see citing works

Organization of endogenous opiate and nonopiate pain control systems

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Method for quantitative estimation of thermal thresholds in patients.

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Opioid and Nonopioid Mechanisms of Stress Analgesia

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Colorectal distension as a noxious visceral stimulus: physiologic and pharmacologic characterization of pseudaffective reflexes in the rat

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Antinociceptive actions of spinal nonsteroidal anti-inflammatory agents on the formalin test in the rat.

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Visceral pain: a review of experimental studies

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Pain “relief” by frontal cingulumotomy

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The formalin test: scoring properties of the first and second phases of the pain response in rats

Abbott, F. V., Franklin, K. B. J., & Westbrook, R. F. (1995) · Pain · doi:10.1016/0304-3959(94)00095-v · Cited by 587 · see citing works

Comparative study of perceived pain and nociceptive flexion reflex in man

Willer, J. C. (1977) · Pain · doi:10.1016/0304-3959(77)90036-7 · Cited by 554 · see citing works

Reflex Activity of the Spinal Cord.

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Ultrasonic Communication by Animals

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Sensory innervation of the viscera: peripheral basis of visceral pain

Cerveró, F. (1994) · Physiological Reviews · doi:10.1152/physrev.1994.74.1.95 · Cited by 526 · see citing works

The activity of neurons in the rostral medulla of the rat during withdrawal from noxious heat

Fields, H. L., Bry, J., Hentall, I. D., & Zorman, G. (1983) · Journal of Neuroscience · doi:10.1523/jneurosci.03-12-02545.1983 · Cited by 518 · see citing works

Tension receptors in the stomach and the urinary bladder

Iggo, A. (1955) · The Journal of Physiology · doi:10.1113/jphysiol.1955.sp005327 · Cited by 515 · see citing works

Further evidence for ‘pain-related’ behaviours in a model of unilateral peripheral mononeuropathy

Attal, N., Jazat, F., Kayser, V., & Guilbaud, G. (1990) · Pain · doi:10.1016/0304-3959(90)90022-6 · Cited by 503 · see citing works

A Method for Evaluating both Non-Narcotic and Narcotic Analgesics

Siegmund, E. A., Cadmus, R., & Lu, G. (1957) · Experimental Biology and Medicine · doi:10.3181/00379727-95-23345 · Cited by 495 · see citing works

Synaptic actions in motoneurones by afferents in which may evoke the flexion reflex

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The measurement of pain; prototype for the quantitative study of subjective responses.

Beecher, H. K. (1957) · PubMed · Cited by 490 · see citing works

Protons selectively induce lasting excitation and sensitization to mechanical stimulation of nociceptors in rat skin, in vitro

Steen, K. H., Reeh, P. W., Anton, F., & Handwerker, H. O. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-01-00086.1992 · Cited by 487 · see citing works

Formalin-evoked activity in identified primary afferent fibers: systemic lidocaine suppresses phase-2 activity

Puig, S., & Sorkin, L. S. (1996) · Pain · doi:10.1016/0304-3959(95)00121-2 · Cited by 473 · see citing works

Evaluation of Drug Activities: Pharmacometrics

Després, L., & Bacharach, A. L. (1964) · Cited by 463 · see citing works

Comparison of responses of warm and nociceptive C-fiber afferents in monkey with human judgments of thermal pain

LaMotte, R. H., & Campbell, J. N. (1978) · Journal of Neurophysiology · doi:10.1152/jn.1978.41.2.509 · Cited by 456 · see citing works

RELATIONSHIP OF SIGNIFICANCE OF WOUND TO PAIN EXPERIENCED

Beecher, H. K. (1956) · JAMA · doi:10.1001/jama.1956.02970170005002 · Cited by 454 · see citing works

Time‐dose relationships for locomotor activity effects of morphine after acute or repeated treatment

Babbini, M., & Davis, W. M. (1972) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1972.tb06866.x · Cited by 443 · see citing works

Evidence for two different heat transduction mechanisms in nociceptive primary afferents innervating monkey skin.

Treede, R., Meyer, R. A., Raja, S. N., & Campbell, J. N. (1995) · The Journal of Physiology · doi:10.1113/jphysiol.1995.sp020619 · Cited by 440 · see citing works

Enhancement of dynorphin gene expression in spinal cord following experimental inflammation: stimulus specificity, behavioral parameters and opioid receptor binding

Iadarola, M. J., Brady, L. S., Draisci, G., & Dubner, R. A. (1988) · Pain · doi:10.1016/0304-3959(88)90141-8 · Cited by 437 · see citing works

The genetic mediation of individual differences in sensitivity to pain and its inhibition

Mogil, J. S. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.14.7744 · Cited by 433 · see citing works

Brain Stem Control of Spinal Mechanisms

Chandler, C., Hewitt, J. R., Miller, S. N., & Tan, N. (1982) · Cited by 428 · see citing works

Behavioral and physiological studies of non-narcotic analgesia in the rat elicited by certain environmental stimuli

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BEHAVIORAL EFFECTS OF SOME PSYCHOPHARMACOLOGICAL AGENTS

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Interactions between cardiovascular and pain regulatory systems

Randich, A., & Maixner, W. D. (1984) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(84)90057-5 · Cited by 409 · see citing works

Pain in the trigeminal region

Bowsher, D. R. (1978) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(78)90254-x · Cited by 404 · see citing works

The formalin test in mice: effect of formalin concentration

Rosland, J. H., Tjølsen, A., Maehle, B. O., & Hole, K. (1990) · Pain · doi:10.1016/0304-3959(90)91167-h · Cited by 399 · see citing works

Nociceptive responses to high and low rates of noxious cutaneous heating are mediated by different nociceptors in the rat: behavioral evidence

Yeomans, D. C., Pirec, V., & Proudfit, H. K. (1996) · Pain · doi:10.1016/s0304-3959(96)03176-4 · Cited by 395 · see citing works

Stress-induced analgesia: adaptive pain suppression

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The normal sural nerve in man

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Assessment of pain in animals

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Standardization of the rat paw formalin test for the evaluation of analgesics

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STUDIES ON PAIN. A NEW METHOD FOR MEASURING PAIN THRESHOLD: OBSERVATIONS ON SPATIAL SUMMATION OF PAIN

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Spinal sensorimotor systems and their supraspinal control

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NEURON PATTERNS CONTROLLING TRANSMISSION OF IPSILATERAL HIND LIMB REFLEXES IN CAT

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Psychophysiology of experimentally induced pain

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The rat paw formalin test: comparison of noxious agents

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ANTAGONISM OF THE FREQUENCY OF PHENYLQUINONE-INDUCED WRITHING IN THE MOUSE BY WEAK ANALGESICS AND NONANALGESICS

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THE EFFECTS OF MORPHINE, METHADONE AND MEPERIDINE ON SOME REFLEX RESPONSES OF SPINAL ANIMALS TO NOCICEPTIVE STIMULATION

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Relationship between pain and tissue damage due to thermal radiation

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Perceptual changes accompanying controlled preferential blocking of A and C fibre responses in intact human skin nerves

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Supraspinal control of interneurones mediating spinal reflexes

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Sensory mechanisms in mammalian teeth and their supporting structures.

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A limited arthritic model for chronic pain studies in the rat

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Vagal afferent modulation of nociception

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Observations on the scratch‐reflex in the spinal dog

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Chapter 17 Columnar organization in the midbrain periaqueductal gray and the integration of emotional expression

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Substance P and calcitonin gene-related peptide synergistically modulate the gain of the nociceptive flexor withdrawal reflex in the rat

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Nociceptive responses to high and low rates of noxious cutaneous heating are mediated by different nociceptors in the rat: electrophysiological evidence

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Conduction failure in myelinated and non‐myelinated axons at low temperatures

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The Lower Brainstem and Bodily Homeostasis

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Capsaicin: actions on nociceptive C-fibres and therapeutic potential

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The capsaicin test in mice for evaluating tachykinin antagonists in the spinal cord

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The formalin test: a validation of the weighted-scores method of behavioural pain rating

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Antinociceptive activity of narcotic agonist and partial agonist analgesics and other agents in the tail-immersion test in mice and rats

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The bee venom test: a new tonic-pain test

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THE TAIL OF THE RAT, IN TEMPERATURE REGULATION AND ACCLIMATIZATION

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Presynaptic hyperpolarization: a role for fine afferent fibres

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Selective activation of small motor axons by quasitrapezoidal current pulses

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A psychophysical analysis of morphine analgesia

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Antinociceptive activity of the bradykinin B1 and B2 receptor antagonists, des-Arg9, [Leu8]-BK and HOE 140, in two models of persistent hyperalgesia in the rat

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The Midbrain periaqueductal gray matter : functional, anatomical, and neurochemical organization

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Do insects feel pain? — A biological view

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Vertebral Muscles of the Back and Tail of the Albino Rat (Rattus norvegicus albinus); pp. 1–23

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A pseudaffective reflex and its spinal path

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Up–Down Reader: An Open Source Program for Efficiently Processing 50% von Frey Thresholds

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Zwierzęce modele nocyceptywnego bólu

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