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THE EVALUATION OF THE ANALGESIC ACTION OF PETHIDINE HYDROCHLORIDE (DEMEROL)
Abstract
1. A new method for the evaluation of analgesics is described. 2. By the use of this method, comparison of morphine, diacetylmorphine, codeine and pethidine hydrochlorides has been made. 3. Pethidine hydrochloride has been found to possess one fifth to one sixth of the analgesic activity of morphine hydrochloride against mild pain stimuli, but to be ineffective against severe pain. 4. Aminopyrine and antipyrin are effective only in very large doses. Phenobarbitone sodium and aspirin have no analgesic action that can be detected by this method.
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Citations
Cited by
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Le Bars, D., Gozariu, M., & Cadden, S. W. (2001) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01514-x · Cited by 1,459
Methods Used to Evaluate Pain Behaviors in Rodents
Deuis, J. R., Dvorakova, L. S., & Vetter, I. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00284 · Cited by 1,249
Heritability of nociception I: Responses of 11 inbred mouse strains on 12 measures of nociception
Mogil, J. S., Wilson, S. G., Bon, K., Eun Lee, S., Chung, K., Raber, P., Pieper, J. O., Hain, H. S., Belknap, J. K., Hubert, L., et al. (1999) · Pain · doi:10.1016/s0304-3959(98)00197-3 · Cited by 656
Taraxacum—A review on its phytochemical and pharmacological profile
Schütz, K., Carle, R., & Schieber, A. (2006) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2006.07.021 · Cited by 566
Metadata
- Authors
- WOOLFE, G., & MACDONALD, A. D.
- Venue
- The Journal of Pharmacology and Experimental Therapeutics
- Publisher
- Elsevier BV
- Published
- 1944-03
- Volume
- 80
- Issue
- 3
- Pages
- 300-307
- ISSN
- 0022-3565 (ISSN-L)
- OpenAlex
- W2271349088
- Cited by
- 1,049
- References
- 0
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: THE EVALUATION OF THE ANALGESIC ACTION OF PETHIDINE HYDROCHLORIDE (DEMEROL). https://app.cochat.ai/papers/10.1016/s0022-3565(25)09094-9
- The paper
- WOOLFE, G., & MACDONALD, A. D. (1944). THE EVALUATION OF THE ANALGESIC ACTION OF PETHIDINE HYDROCHLORIDE (DEMEROL). The Journal of Pharmacology and Experimental Therapeutics. https://doi.org/10.1016/s0022-3565(25)09094-9
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
