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THE OXIDATION OF DRUGS BY LIVER MICROSOMES: ON THE ROLE OF TPNH AND OXYGEN
Abstract
Liver microsomes contain an enzyme system, TPNH oxidase, which catalyzes the oxidation of TPNH by oxygen to yield TPN and hydrogen peroxide. This enzyme system has been implicated in the oxidative dealkylation of foreign alkylamines such as monomethyl-4-aminoantipyrine by liver microsomes and probably is involved in the other types of microsomal drug enzyme systems requiring TPNH and oxygen. Some possible mechanisms by which TPNH oxidase may participate in these drug enzyme systems are discussed.
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Citations
Cited by
The Carbon Monoxide-binding Pigment of Liver Microsomes
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Crosstalk of reactive oxygen species and NF-κB signaling
Morgan, M. J., & Liu, Z.-G. (2011) · Cell Research · doi:10.1038/cr.2010.178 · Cited by 3,505
Health effects of quercetin: From antioxidant to nutraceutical
Boots, A. W., Haenen, G. R. M. M., & Bast, A. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2008.03.008 · Cited by 2,121
Wang, M., Roberts, D. L., Paschke, R., Shea, T. M., Masters, B. S. S., & Kim, J.-J. P. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.16.8411 · Cited by 744
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Auchus, R. J., Lee, T. C., & Miller, W. L. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.6.3158 · Cited by 541
Metadata
- Authors
- Gillette, J. H., Brodie, B. B., & La Du, B. N.
- Venue
- The Journal of Pharmacology and Experimental Therapeutics
- Publisher
- Elsevier BV
- Published
- 1957-04
- Volume
- 119
- Issue
- 4
- Pages
- 532-540
- ISSN
- 0022-3565 (ISSN-L)
- OpenAlex
- W4406976184
- Cited by
- 407
- References
- 0
- FWCI
- 6.24
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: THE OXIDATION OF DRUGS BY LIVER MICROSOMES: ON THE ROLE OF TPNH AND OXYGEN. https://app.cochat.ai/papers/10.1016/s0022-3565(25)11915-0
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- Gillette, J. H., Brodie, B. B., & La Du, B. N. (1957). THE OXIDATION OF DRUGS BY LIVER MICROSOMES: ON THE ROLE OF TPNH AND OXYGEN. The Journal of Pharmacology and Experimental Therapeutics. https://doi.org/10.1016/s0022-3565(25)11915-0
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