Arbutin: mechanism of its depigmenting action in human melanocyte culture

Anti-Melanogenic Effects of Lilium lancifolium Root Extract via Downregulation of PKA/CREB and MAPK/CREB Signaling Pathways in B16F10 Cells

Park, S., Han, N., Lee, J., Lee, J.-N., An, S., & Bae, S. (2023) · Plants · doi:10.3390/plants12213666 · Cited by 15

Sargahydroquinoic Acid Suppresses Hyperpigmentation by cAMP and ERK1/2-Mediated Downregulation of MITF in α-MSH-Stimulated B16F10 Cells

Azam, M. S., Kim, J., Choi, C. G., Choi, J., Lee, B., & Kim, H. (2021) · Foods · doi:10.3390/foods10102254 · Cited by 15

A newly synthesized, potent tyrosinase inhibitor: 5-(6-Hydroxy-2-naphthyl)-1,2,3-benzenetriol

Choi, J., Bae, S. J., Ha, Y. M., No, J. K., Lee, E. K., Lee, J. S., Song, S., Lee, H., Suh, H., Yu, B. P., et al. (2010) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2010.06.087 · Cited by 15

Effects of Salicylic Acid on Mushroom Tyrosinase and B16 Melanoma Cells

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Capsaicin reverses the inhibitory effect of licochalcone A/β-Arbutin on tyrosinase expression in b16 mouse melanoma cells

Liu, Q., Hong, J.-H., Chen, H., Xiang, S., Cao, S., An, B., Ruan, S.-F., Zhang, B., Weng, L., & Zhu, H. (2018) · Pharmacognosy Magazine · doi:10.4103/pm.pm_103_17 · Cited by 15

INHIBITION OF MELANOGENIC ACTIVITY BY GELATIN AND POLYPEPTIDES FROM PACIFIC COD SKIN IN B16 MELANOMA CELLS

Hou, H., Zhao, X., Li, B., Zhang, Z., & Zhuang, Y. (2011) · Journal of Food Biochemistry · doi:10.1111/j.1745-4514.2010.00437.x · Cited by 15

Melanogenesis inhibitors from Rabdosia japonica

Satooka, H., Isobe, T., Nitoda, T., & Kubo, I. (2012) · Phytomedicine · doi:10.1016/j.phymed.2012.05.007 · Cited by 14

Herbal cosmetics: An overview

Kumar, D., Rajora, G., Parkash, O., Himanshu, Antil, M., & Kumar, V. (2016) · International Journal of Advanced Scientific Research · Cited by 14

A Novel Class of Potent Anti-Tyrosinase Compounds with Antioxidant Activity, 2-(Substituted phenyl)-5-(trifluoromethyl)benzo[d]thiazoles: In Vitro and In Silico Insights

Hwang, Y., Lee, J., Jung, H. J., Ullah, S., Ko, J., Jeong, Y., Park, Y. J., Kang, M. K., Yun, H., Kim, M., et al. (2022) · Antioxidants · doi:10.3390/antiox11071375 · Cited by 14

Inhibitory effects of chestnut inner skin extracts on melanogenesis

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Inhibitory mechanism of cardanols on tyrosinase

Yu, X.-P., Su, W.-C., Wang, Q., Zhuang, J.-X., Tong, R.-Q., Chen, Q., & Chen, Q. (2016) · Process Biochemistry · doi:10.1016/j.procbio.2016.09.019 · Cited by 14

Botanicals With Dermatologic Properties Derived From First Nations Healing: Part 2—Plants and Algae

Colantonio, S., & Rivers, J. K. (2016) · Journal of Cutaneous Medicine and Surgery · doi:10.1177/1203475416683390 · Cited by 14

Melanocyte‐stimulating Properties of Secretory Phospholipase A2

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Arbutin Enhances Recovery and Osteogenic Differentiation in Dried and Rehydrated Human Mesenchymal Stem Cells

Jamil, K., Crowe, J. H., Tablin, F., & Oliver, A. E. (2005) · Cell Preservation Technology · doi:10.1089/cpt.2005.3.244 · Cited by 14

Antimelanogenic Effect and Whitening of Anthocyanin Rich Fraction from Seeds of Liriope platyphylla

Choung, M. G., Hwang, Y. S., Kim, G. P., Ahn, K.-G., Shim, H. S., Hong, S., Choi, J. H., Yu, C. Y., Chung, I. M., Kim, S., et al. (2013) · Korean Journal of Medicinal Crop Science · doi:10.7783/kjmcs.2013.21.5.361 · Cited by 14

Microbial cellulosic pad encompassing alpha-arbutin in Tragacanth gum as the controlled delivery system

Fahim, N. H., Montazer, M., Hemmatinejad, N., Toliyat, T., & Rad, M. M. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.123292 · Cited by 13

Modification of skin discoloration by a topical treatment containing an extract ofDianella ensifolia: a potent antioxidant

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Arbutin determination in medicinal plants and creams

Thongchai, W., Liawruangrath, B., & Liawruangrath, S. (2009) · International Journal of Cosmetic Science · doi:10.1111/j.1468-2494.2008.00481.x · Cited by 13

Facial skin-lightening benefits of the tetrapeptide Pro-Lys-Glu-Lys on subjects with skin types V-VI living in South Africa

Farwick, M., Maczkiewitz, U., Lersch, P., Summers, B., & Rawlings, A. V. (2011) · Journal of Cosmetic Dermatology · doi:10.1111/j.1473-2165.2011.00569.x · Cited by 13

Preparation and evaluation of solid lipid nanoparticles with JSH18 for skin-whitening efficacy

So, J.-W., Kim, S.-J., Park, J., Kim, B.-H., Jung, S., Shin, S., & Cho, C. (2009) · Pharmaceutical Development and Technology · doi:10.1080/10837450903262066 · Cited by 13

Antimelanogenesis Effects of Fungal Exopolysaccharides Prepared from Submerged Culture of Fomitopsis castanea Mycelia

Jin, J., Nguyen, T. T. H., Kim, C., & Kim, D. (2019) · Journal of Microbiology and Biotechnology · doi:10.4014/jmb.1905.05037 · Cited by 13

Inhibitory Effect of Sesamolin on Melanogenesis in B16F10 Cells Determined by In Vitro and Molecular Docking Analyses

Baek, S., Kang, M.-G., & Park, D. (2020) · Current Pharmaceutical Biotechnology · doi:10.2174/1389201020666191011151123 · Cited by 13

Inhibition of Melanogenesis in Murine B16/F10 Melanoma Cells byLigusticum sinensis Oliv.

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Optimum extraction conditions for arbutin from Asian pear peel by supercritical fluid extraction (SFE) using Box-Behnken design

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Anti-melanogenic effect of gomisin N from Schisandra chinensis (Turcz.) Baillon (Schisandraceae) in melanoma cells

Lee, J., Ryu, H. S., Kim, J.-M., Jung, T.-H., Park, S., & Lee, Y. (2017) · Archives of Pharmacal Research · doi:10.1007/s12272-017-0903-4 · Cited by 13

Anti-melanin deposition activity and active constituents of Jatropha multifida stems

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Design, synthesis, and inhibitory activity of hydroquinone ester derivatives against mushroom tyrosinase

Dong, X., Han, K., Jiang, Q., Xie, S., Zhou, J., Zhang, Y., Xu, J., He, Y., Zhao, P., & Yang, X. (2024) · RSC Advances · doi:10.1039/d4ra00007b · Cited by 12

Anti-melanogenic properties of honeybee ( Apis mellifera L.) venom in α-MSH-stimulated B16F1 cells

Han, S. M., Kim, J. M., & Pak, S. C. (2014) · Food and Agricultural Immunology · doi:10.1080/09540105.2014.950202 · Cited by 12

Revolutionizing plant-based extracts for skin care and therapeutics

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Methoxyflavones from Black Ginger (Kaempferia parviflora Wall. ex Baker) and their Inhibitory Effect on Melanogenesis in B16F10 Mouse Melanoma Cells

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Preformulation and formulation of newly synthesized QNT3-18 for development of a skin whitening agent

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Wnt/β-catenin signaling inhibitor ICG-001 enhances pigmentation of cultured melanoma cells

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Deoxyarbutin displays antitumour activity against melanoma in vitro and in vivo through a p38-mediated mitochondria associated apoptotic pathway

Ma, L., Xu, Y., Wei, Z., Xin, G., Xing, Z., Niu, H., & Huang, W. Q. (2017) · Scientific Reports · doi:10.1038/s41598-017-05416-8 · Cited by 12

Arbutin in Serratula quinquefolia M.B. (Asteraceae)

Nowak, G., Nawrot, J., & Latowski, K. (2011) · Acta Societatis Botanicorum Poloniae · doi:10.5586/asbp.2009.018 · Cited by 12

Phenolic composition, antioxidant and enzyme inhibitory activities of ethanol and water extracts of Chenopodium botrys

Özer, M. S., Sarıkürkçü, C., & Tepe, B. (2016) · RSC Advances · doi:10.1039/c6ra13229d · Cited by 12

Inhibitory Effects of Phyllostachys bambusoides on Melanin Synthesis and Tyrosinase Activity in Cultured Human Melanoma Cells

Huh, M. K., Han, M. H., Park, C., & Choi, Y. H. (2014) · Journal of Life Science · doi:10.5352/jls.2014.24.3.284 · Cited by 11

Tyrosinase Inhibitory Compounds Isolated from Persicaria tinctoria Flower

Woo, Y. M., Kim, A.-J., Kim, J.-Y., & Lee, C.-H. (2011) · Journal of Applied Biological Chemistry · doi:10.3839/jabc.2011.008 · Cited by 11

New arbutin derivatives from the leaves of Heliciopsis lobata with cytotoxicity

Qi, W., Na, O. U., Xiao-Dong, W. U., & Xu, H. (2016) · Chinese Journal of Natural Medicines · doi:10.1016/s1875-5364(16)30094-2 · Cited by 11

Molecular spectroscopic behaviors of beta-arbutin in anti-skin cancer

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Prenylated Flavonoids as Antioxidant and Melanin Inhibitors From Stingless Bee ( Wallacetrigona incisa ) Propolis

Arung, E. T., Syafrizal, Pasedan, W. F., Tandirogang, N., Sukemi, Allam, A. E., Amen, Y. M., Shimizu, K., & Ishikawa, H. (2020) · Natural Product Communications · doi:10.1177/1934578x20911272 · Cited by 11

Chemical synthesis and tyrosinase inhibitory activity of resorcinol alkyl glucosides, hydroxyalkyl resorcinols, and alkyl resorcinols

Ishioka, W., & Nihei, K. (2022) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2022.133668 · Cited by 11

Chemistry of Cosmetics

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Screening of an Epigenetic Drug Library Identifies 4-((hydroxyamino)carbonyl)-N-(2-hydroxyethyl)-N-Phenyl-Benzeneacetamide that Reduces Melanin Synthesis by Inhibiting Tyrosinase Activity Independently of Epigenetic Mechanisms

Song, H., Hwang, Y. J., Ha, J. W., & Boo, Y. C. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21134589 · Cited by 11

N-retinoyl-D-glucosamine, a new retinoic acid agonist, mediates topical retinoid efficacy with no irritation on photoaged skin

Kambayashi, H., Odake, Y., Takada, K., Funasaka, Y., Ichihashi, M., & Kato, S. (2005) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2005.06967.x · Cited by 11

Effect of saucerneol D on melanin production in cAMP-elevated melanocytes

Yun, J. Y., Roh, E., Son, J.-K., Lee, S. H., Seo, C., Hwang, B. Y., Han, S., & Kim, Y. S. (2011) · Archives of Pharmacal Research · doi:10.1007/s12272-011-0814-8 · Cited by 11

Topical treatment of hyperpigmentation disorders

Rendon, M. I., & Horwitz, S. (2012) · Annales de Dermatologie et de Vénéréologie · doi:10.1016/s0151-9638(12)70128-x · Cited by 11

Inhibitory Effect of Endarachne binghamiae Extract on Melanin Synthesis

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Elucidating the chemical profile and biological studies of Verbascum diversifolium Hochst. extracts

Yagi, S. M. A., Nilofar, N., Uba, A. İ., Caprioli, G., Mustafa, A. M., Angeloni, S., Koyuncu, İ., Seker, F., Polat, R., Supti, S. J., et al. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1333865 · Cited by 10

Melasma management: Unveiling recent breakthroughs through literature analysis

Kumar, D. R., Sood, R., & Tiwari, P. K. (2025) · Health Sciences Review · doi:10.1016/j.hsr.2025.100213 · Cited by 10

Synthesis, Characterization, and Evaluation of Thiazolidine Derivatives of Cysteine for Suppressing Eumelanin Production

Amino, Y., Takino, Y., Kaneko, M., Ookura, F., Yamamoto, M., Kashiwagi, T., & Iwasaki, K. (2016) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.c16-00509 · Cited by 10

Antimelanogenesis Effect of Methyl Gallate through the Regulation of PI3K/Akt and MEK/ERK in B16F10 Melanoma Cells

Cheng, Z. J., Dai, G.-F., Hsu, J., Lin, J. J., Wu, W. T., Su, C., & Wu, Y. (2022) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2022/5092655 · Cited by 11

Metabolomic analysis and bioactivities of Arbutus unedo leaves harvested across the seasons in different natural habitats of Sardinia (Italy)

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Combination peel with incorporated fractional prickle coral calcium for the treatment of keratosis pilaris: a pilot study

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1-(2,4-Dihydroxyphenyl)-3-(2,4-dimethoxy-3-methylpheny)propane inhibits melanin synthesis by dual mechanisms

Niki, Y., Yoshida, M., Ando, H., Wakamatsu, K., Ito, S., Harada, N., Matsui, M. S., Yarosh, D. B., & Ichihashi, M. (2011) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2011.04.002 · Cited by 10

Degradation of Tyrosinase by Melanosomal pH Change and a New Mechanism of Whitening with Propylparaben

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Decursin and Z-Ligustilide in Angelica tenuissima Root Extract Fermented by Aspergillus oryzae Display Anti-Pigment Activity in Melanoma Cells

Park, Y., Kim, D., Yang, I., Choi, B., Lee, J. W., Namkoong, S., Koo, H. J., Lee, S. R., Park, M. R., Lim, H., et al. (2018) · Journal of Microbiology and Biotechnology · doi:10.4014/jmb.1812.02044 · Cited by 10

Topical L-Ascorbic Acid

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Inhibitory Effects of (2′ R )‐2′,3′‐dihydro‐2′‐(1‐hydroxy‐1‐methylethyl)‐2,6′‐bibenzofuran‐6,4′‐diol on Mushroom Tyrosinase and Melanogenesis in B16‐F10 Melanoma Cells

Zhu, J., Yan, G., Xu, Z., Hu, X., Wang, G., Wang, T., Zhu, W., Hou, A., & Wang, H. (2015) · Phytotherapy Research · doi:10.1002/ptr.5344 · Cited by 10

Daedalin A, a Metabolite ofDaedalea dickinsii, Inhibits Melanin Synthesis in anin VitroHuman Skin Model

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Melanin Biosynthesis Inhibitors from TarragonArtemisia dracunculus

YAMADA, M., NAKAMURA, K. W., WATABE, T., Ohno, O., Kawagoshi, M., Maru, N., Uotsu, N., CHIBA, T., Yamaguchi, K., & Uemura, D. (2011) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.110306 · Cited by 10

Anti-Oxidative, Anti-Inflammatory, and Anti-Melanogenic Activities of Endlicheria Anomala Extract

Jin, K.-S., Lee, J. Y., Kwon, H. J., & Kim, B. W. (2013) · Microbiology and Biotechnology Letters · doi:10.4014/kjmb.1309.09005 · Cited by 10

Biological and phytochemical evaluation: Pseudevernia furfuracea as an alternative multifunctional agent

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Narayanaswamy, N., Duraisamy, A., & Balakrishnan, K. P. (2011) · Cited by 10

Phenolic Constituents of Carex vulpinoidea Seeds and their Tyrosinase Inhibitory Activities

Niesen, D. B., Ma, H., Yuan, T., Bach, A., Henry, G. E., & Seeram, N. P. (2015) · Natural Product Communications · doi:10.1177/1934578x1501000328 · Cited by 10

Novel Anti-Melanogenic Compounds, (Z)-5-(Substituted Benzylidene)-4-thioxothiazolidin-2-one Derivatives: In Vitro and In Silico Insights

Choi, H.-J., Ryu, I. Y., Choi, I., Ullah, S., Jung, H. J., Park, Y., Jeong, Y., Hwang, Y., Hong, S., Yoon, I., et al. (2021) · Molecules · doi:10.3390/molecules26164963 · Cited by 10

Prevention and Treatment of Aging Skin with Topical Antioxidants

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Anti-melanogenic effects of hydroxyethyl chrysin through the inhibition of tyrosinase activity: In vitro and in silico approaches

Lee, Y., Song, H.-Y., & Byun, E. (2025) · Heliyon · doi:10.1016/j.heliyon.2025.e41718 · Cited by 9

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Ko, J., Lee, J., Jung, H. J., Ullah, S., Jeong, Y., Hong, S., Kang, M. K., Park, Y. J., Hwang, Y., Kang, D., et al. (2022) · Antioxidants · doi:10.3390/antiox11101918 · Cited by 9

Antimelanogenic potential of brewer's spent grain extract through modulation of the MAPK/MITF axis

Shon, Y. J., Kim, W.-C., Lee, S., Hong, S., Kim, S., Park, M. H., Lee, P., Lee, J.-H., Park, K. H., Lim, W., et al. (2023) · Sustainable materials and technologies · doi:10.1016/j.susmat.2023.e00721 · Cited by 9

Momilactione B inhibits protein kinase A signaling and reduces tyrosinase-related proteins 1 and 2 expression in melanocytes

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Physicochemical studies of a newly synthesized molecule, 6-methyl-3-phenethyl-3,4-dihydro-1H-quinazoline-2-thione (JSH18) for topical formulations

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Synthesis and biological evaluation of polyhydroxy benzophenone as mushroom tyrosinase inhibitors

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Effect of Various Pear Cultivars at Different Fruit Development Stages on Antioxidant and Whitening Activities

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Root polysaccharides of Panax notoginseng alleviated melasma by regulating the Nrf2/ARE signaling pathway

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Melanin biosynthesis inhibitory effects of calycosin-7-O-β-d-glucoside isolated from astragalus (Astragalus membranaceus)

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Synthesis of novel monostyryl and distyryl boron dipyrromethenes bearing 4-((2-hydroxyethyl)(methyl)amino group as cholinesterase and tyrosinase inhibitors

Arslan, T., Keleş, T., Barut, B., Özel, A., & Bıyıklıoğlu, Z. (2017) · Inorganica Chimica Acta · doi:10.1016/j.ica.2017.10.020 · Cited by 8

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Borage Oil Treated with Immobilized Lipase Inhibits Melanogenesis

Shin, J. A., Sun, M., & Jeong, J. (2020) · Lipids · doi:10.1002/lipd.12266 · Cited by 8

Synthesis of lipophilic arbutin ester by enzymatic transesterification in high pressure carbon dioxide

Liu, K.-J. (2021) · Enzyme and Microbial Technology · doi:10.1016/j.enzmictec.2021.109818 · Cited by 8

Photoprotection of the Skin with Vitamins C and E: Antioxidants and Synergies

Burke, K. (2011) · Springer eBooks · doi:10.1007/978-1-4419-7967-4_4 · Cited by 8

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Lee, J.-H., Pillaiyar, T., LEE, K. ‐., Bang, S., Kim, M., Sharma, V. K., Yun, C., Roh, E., Kim, Y. S., & Jung, S. (2010) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.58.918 · Cited by 8

In vitro inhibitory potential of methanolic extract of Celosia argentea var. cristata on tyrosinase, acetylcholinesterase and butyrylcholinesterase enzymes

Saqib, F., Janbaz, K. H., & Sherwani, M. K. (2015) · Bangladesh Journal of Pharmacology · doi:10.3329/bjp.v10i2.22880 · Cited by 8

Anisaldehyde, a Melanogenesis Potentiator

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