The DOI matches its Crossref record.
Food deprivation and acquisition of intravenous cocaine self-administration in rats: effect of naltrexone and haloperidol.
Abstract
In order to create optimal conditions for the acquisition of i.v. cocaine self-administration in the rat, three groups of rats were deprived of food to different extents in order to obtain body weight reductions of 5 to 15, 15 to 25 and 25 to 35% of the pre-experimental body weights, and were tested for five consecutive 6-hr sessions in a continuous reinforcement procedure for self-administration of cocaine (0.12 mg/ml) or saline. Self-administration interacted with weight loss and indicated that: 1) a minimum level of 15 to 25% weight loss was required to obtain cocaine self-administration; 2) weight loss-induced potentiation of cocaine self-administration resulted from an interaction of increased nonspecific lever pressing activity and increased reinforcing effects of the compound; and 3) optimal differentiation between cocaine- and saline-induced responding was obtained at 15 to 25% weight loss. Daily pretreatment during the five test sessions, with 0.1 to 1.0 mg/kg of naltrexone or 43 to 375 micrograms/kg of haloperidol, dose-dependently decreased the number of cocaine (0.12 mg/ml) self-injections. Naltrexone pretreatment, and to a lesser extent haloperidol pretreatment, appeared to affect cocaine self-administration in a specific manner; both treatments affected responding on the reinforced lever, but not responding on the nonreinforced lever. Self-administration of 0.06 mg/ml of cocaine tended to be decreased by naltrexone (1 mg/kg) and haloperidol (375 micrograms/kg); whereas self-administration induced by 0.25 mg/ml of cocaine was not significantly affected by naltrexone or haloperidol. Both treatments failed to affect self-administration of saline.(ABSTRACT TRUNCATED AT 250 WORDS)
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“While opiate drugs are themselves strongly addictive, the role of the endogenous opioid system in addiction is not limited to these, as this system plays a strong role in the development of addiction to every class of drug (Altshuler et al 1980; Karras and Kane 1980; De Vry et al 1989; Kuzmin et al 1997; Ismayilova and Shoaib 2010; for a review see van Ree et al, 1999).”
From The behavioral, anatomical and pharmacological parallels between social attachment, love and addiction (2012) · cites this paper as De Vry et al 1989
Citations
Cites
Still being checked.
Cited by
Sorted by citations
Items 101–134 of 134
Potentiation of opioid analgesia by cocaine: The role of spinal and supraspinal receptors
Sierra, V., Duttaroy, A., Lutfy, K., Candido, J., Billings, B., Zito, S. W., & Yoburn, B. C. (1992) · Life Sciences · doi:10.1016/0024-3205(92)90371-u · Cited by 18
Gerrits, M. A. F. M., & van Ree, J. M. (1995) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(95)00112-a · Cited by 17
Housing conditions influence acquisition of sufentanil aerosol self-administration in rats
Weinhold, L. L., Sharpe, L. G., & Jaffe, J. H. (1993) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(93)90291-z · Cited by 17
Effect of food restriction on cocaine locomotor sensitization in Sprague–Dawley rats
Allen, C. P., Zhou, Y., & Leri, F. (2012) · Psychopharmacology · doi:10.1007/s00213-012-2930-7 · Cited by 15
Morphinome ? proteome of the nervous system after morphine treatment
Bodzoń‐Kułakowska, A., Bierczyńska-Krzysik, A., Drabik, A., Noga, M. J., Kraj, A., Suder, P., & Silberring, J. (2004) · Amino Acids · doi:10.1007/s00726-004-0144-y · Cited by 15
Suzuki, T., Mori, T., Tsuji, M., Misawa, M., & Nagase, H. (1997) · European Journal of Pharmacology · doi:10.1016/s0014-2999(97)01020-0 · Cited by 14
ERK1/2 activation in rat ventral tegmental area by the μ-opioid agonist fentanyl: an in vitro study
Lesscher, H. M. B., Burbach, J. P. H., van Ree, J. M., & Gerrits, M. A. F. M. (2003) · Neuroscience · doi:10.1016/s0306-4522(02)00552-3 · Cited by 13
Grasing, K., He, S., & Yang, Y. (2009) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2009.08.004 · Cited by 12
Selective breeding for intravenous drug self-administration in rats: a pilot study
He, S., Yang, Y., Mathur, D., & Grasing, K. (2008) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e32831c3aec · Cited by 12
Cappendijk, S. L. T., Fekkes, D., van Dalen, A., & Pepplinkhuizen, L. (2001) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(01)00090-6 · Cited by 11
Acute effects of bezafibrate on blood pressure and renal haemodynamics in SHR and WKY rats.
Agrawal, B., Kopecká, J., nzlin, B. K., Rohmeiss, P., Pill, J., & Gretz, N. (1998) · Nephrology Dialysis Transplantation · doi:10.1093/oxfordjournals.ndt.a027827 · Cited by 11
Cocaine Effects on Dopamine and Opioid Peptide Neural Systems: Implications for Human Cocaine Abuse
Hurd, Y. L. (1996) · PsycEXTRA Dataset · doi:10.1037/e495672006-006 · Cited by 11
Inability to Control Eating: Addiction to Food or Normal Response to Abnormal Environment?
Goodrick, G. K. (2000) · Drugs & Society · doi:10.1300/j023v15n01_07 · Cited by 8
Bergvall, Å. H. (1996) · Physiology & Behavior · doi:10.1016/0031-9384(95)02156-6 · Cited by 8
Windisch, K. A., Morochnik, M., Reed, B., & Kreek, M. J. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108590 · Cited by 7
Neuropeptides and psychopathology
van Ree, J. M. (1994) · Journal of Controlled Release · doi:10.1016/0168-3659(94)90076-0 · Cited by 5
Endogenous Opiates, Addiction, and the Stress Response
Chong, R. Y., Uhart, M., & Wand, G. S. (2007) · Elsevier eBooks · doi:10.1016/b978-012370632-4/50007-3 · Cited by 5
Nowak, D. B., Taborda-Bejarano, J. P., Chaure, F. J., Mantsch, J. R., & García‐Keller, C. (2025) · Cells · doi:10.3390/cells14131014 · Cited by 4
Doyle, M. R., Peng, L. N., Cao, J., Rice, K. C., Newman, A. H., & Collins, G. T. (2023) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.122.001419 · Cited by 4
Novel pharmacotherapies for cocaine abuse - 1995 to present
Glowa, J. R., LeSage, M. G., Stafford, D. A., & Vocci, F. J. (1997) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543776.7.12.1459 · Cited by 4
Cigarette Smoking, Substance Abuse, Nutritional Status, and Immune Function
Golub, M. S. (2000) · Humana Press eBooks · doi:10.1007/978-1-59259-709-3_22 · Cited by 3
The involvement of endorphins and dopamine in experimental addiction
van Ree, J. M., Gerrits, M. A. F. M., & Ramsey, N. F. (1992) · European Neuropsychopharmacology · doi:10.1016/0924-977x(92)90074-i · Cited by 3
Contribution of Stress to Cocaine Addiction
Mantsch, J. R. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-803750-8.00003-8 · Cited by 2
Opiate antagonists and addiction
van Ree, J. M. (1993) · European Neuropsychopharmacology · doi:10.1016/0924-977x(93)90037-m · Cited by 2
Effects of Opioid Antagonists on the Abuse-Related Effects of Psychomotor Stimulants and Nicotine
Gehrke, B. J., & Shippenberg, G. S. (2009) · Humana Press eBooks · doi:10.1007/978-1-59745-197-0_15 · Cited by 1
The Role of Serotonin in MDMA Self-administration in Rats
Bradbury, S. (2014) · Figshare · doi:10.26686/wgtn.17008309.v1
Role of the endogenous opioid system in addiction to alcohol and cocaine
Burattini, C. (2007) · AMS Dottorato Institutional Doctoral Theses Repository (University of Bologna) · doi:10.6092/unibo/amsdottorato/444
Endorphins, emotional stress and experimental cocaine addiction
van Ree, J. M., Ramsey, N. F., & Gerrits, M. A. F. M. (1994) · European Neuropsychopharmacology · doi:10.1016/0924-977x(94)90043-4
Ramsey, N. F., & van Ree, J. M. (1990) · European Journal of Pharmacology · doi:10.1016/0014-2999(90)94742-g
Brain opioid mechanisms in amphetamine induced behaviours
Häggkvist, J. (2009) · Figshare
van Ree, J. M. (1994) · Regulatory Peptides · doi:10.1016/0167-0115(94)90293-3
Magalas, Z., & Wagner, H. (2006) · RWTH Publications (RWTH Aachen)
The Role of Serotonin in MDMA Self-administration in Rats
Bradbury, S. (2014) · Open Access Victoria University of Wellington | Te Herenga Waka (Figshare) · doi:10.26686/wgtn.17008309 · Cited by 1
Metadata
- Authors
- De Vry, J., Donselaar, I., & Van Ree, J. M.
- Venue
- The Journal of Pharmacology and Experimental Therapeutics
- Publisher
- Elsevier BV
- Published
- 1989-11
- Volume
- 251
- Issue
- 2
- Pages
- 735-740
- ISSN
- 0022-3565 (ISSN-L)
- OpenAlex
- W2265469528
- Cited by
- 134
- References
- 0
- Citations by year
- 2025: 1 · 2023: 1 · 2021: 1 · 2019: 1 · 2017: 2 · 2014: 4 · 2012: 3
- FWCI
- 1.76
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Pharmacology and Experimental Therapeutics (publishedVersion)
- PubMed (publishedVersion)
- PubMed
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- cocaine self-administration, food deprivation, weight loss, naltrexone, haloperidol, opioid antagonists, antipsychotic drugs, cocaine potentiation, lever pressing, drug discrimination, continuous reinforcement, rats
- MeSH terms
- Animals, Body Weight, Cocaine, Food Deprivation, Haloperidol, Male, Naltrexone, Rats, Inbred Strains, Reinforcement, Psychology, Self Administration, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
