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A METHOD FOR THE FLUOROMETRIC ASSAY OF HISTAMINE IN TISSUES
Abstract
A sensitive and specific fluorometric method for the estimation of histamine in tissues is described. The method involves extraction of histamine into butanol from alkalinized perchloric acid tissue extracts, return to an aqueous phase, and condensation with o -phthalaldehyde to form a highly fluorescent product which is estimated in a spectrofluorometer. Concentrations of histamine as low as 0.005 µg/ml can be assayed. Low levels of histamine (0.2-0.4 µg/g) occur in brain. Gross dissection of brain showed no marked localization of brain histamine.
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Cited by
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A fluorometric assay for glutathione
Cohn, V. H., & Lyle, J. (1966) · Analytical Biochemistry · doi:10.1016/0003-2697(66)90286-7 · Cited by 441
Self-citationBaram, D., Vaday, G. G., Salamon, P., Drucker, I., Hershkoviz, R., & Mekori, Y. A. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.7.4008 · Cited by 233
Prostaglandin E2–EP3 Signaling Induces Inflammatory Swelling by Mast Cell Activation
Morimoto, K., Shirata, N., Taketomi, Y., Tsuchiya, S., Segi-Nishida, E., Inazumi, T., Kabashima, K., Tanaka, S., Murakami, M., Narumiya, S., et al. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1300290 · Cited by 132
Possible role for mast cell-derived cathepsin G in the adverse remodelling of stenotic aortic valves
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Metadata
- Authors
- Shore, P. A., Burkhalter, A., & Cohn, V. H.
- Venue
- The Journal of Pharmacology and Experimental Therapeutics
- Publisher
- Elsevier BV
- Published
- 1959-11
- Volume
- 127
- Issue
- 3
- Pages
- 182-186
- ISSN
- 0022-3565 (ISSN-L)
- OpenAlex
- W1931867546
- Cited by
- 2,397
- References
- 0
- FWCI
- 14.76
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: A METHOD FOR THE FLUOROMETRIC ASSAY OF HISTAMINE IN TISSUES. https://app.cochat.ai/papers/10.1016/s0022-3565(25)25681-6
- The paper
- Shore, P. A., Burkhalter, A., & Cohn, V. H. (1959). A METHOD FOR THE FLUOROMETRIC ASSAY OF HISTAMINE IN TISSUES. The Journal of Pharmacology and Experimental Therapeutics. https://doi.org/10.1016/s0022-3565(25)25681-6
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
