ON THE MECHANISMS OF 14C-NICOTINE DISTRIBUTION IN RAT SUBMAXILLARY GLAND IN VITRO
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Nicotine accumulates within cells, so that the apparent intracellular volume occupied by nicotine is six- to eightfold greater than the total intracellular volume measured, for instance, by inulin exclusion.
“Nicotine accumulates within cells, so that the apparent “intracellular volume” occupied by nicotine is six- to eightfold greater than the total intracellular volume measured, for instance, by inulin exclusion.”
From Nicotine is a selective pharmacological chaperone of acetylcholine receptor number and stoichiometry. Implications for drug discovery (2009) · cites this paper as [77]
Acid trapping produces concentrations of nicotine many times higher than the smoked extracellular concentration within the vesicles of the secretory pathway.
“Acid trapping produces concentrations of nicotine many times higher than the smoked extracellular concentration, within the vesicles of the secretory pathway.”
From Nicotine is a selective pharmacological chaperone of acetylcholine receptor number and stoichiometry. Implications for drug discovery (2009) · cites this paper as [77]
Cited by
Sorted by citations
Lester, H. A., Xiao, C., Srinivasan, R., Son, C. D., Miwa, J., Pantoja, R., Banghart, M. R., Dougherty, D. A., Goate, A. M., & Wang, J. C. (2009) · The AAPS Journal · doi:10.1208/s12248-009-9090-7 · Cited by 163 · see citing works
Addiction‐related neuroadaptations following chronic nicotine exposure
Wills, L., & Kenny, P. J. (2021) · Journal of Neurochemistry · doi:10.1111/jnc.15356 · Cited by 61 · see citing works
- Authors
- PUTNEY, J. W., & BORZELLECA, J. F.
- Affiliations
- Virginia Commonwealth University (US)
- ORCID
- PUTNEY, JAMES W.
- Venue
- The Journal of Pharmacology and Experimental Therapeutics
- Publisher
- Elsevier BV
- Published
- 1971-07
- Volume
- 178
- Issue
- 1
- Pages
- 180-191
- ISSN
- 0022-3565 (ISSN-L)
- OpenAlex
- W1946195737
- Cited by
- 22
- References
- 0
- Citations by year
- 2021: 1 · 2018: 1 · 2017: 1 · 2015: 3 · 2012: 1
- FWCI
- 0.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Pharmacology and Experimental Therapeutics (publishedVersion)
- PubMed (publishedVersion)
- PubMed
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
- Health Sciences › Medicine › Physiology › Salivary Gland Disorders and Functions
- Keywords
- nicotine, submandibular gland, nicotine uptake, passive diffusion, pH dependence, ionization, temperature dependence, intracellular binding, lipid partitioning, rats
- MeSH terms
- Animals, Biological Transport, Active, Carbon Isotopes, Extracellular Space, Hydrogen-Ion Concentration, Kinetics, Male, Nicotine, Oxazoles, Oxygen Consumption, Submandibular Gland, Rats, In Vitro Techniques
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