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A comparison of clonidine with morphine for antinociceptive and antiwithdrawal actions.
Abstract
Clonidine was found to possess dose-dependent analgesic and antiwithdrawal activity. In mice, clonidine prolonged the tail flick latency and inhibited phenylquinone-induced writhing. In rats, it inhibited tail withdrawal from hot water and a pain response to pressure application on an inflamed paw. The effective doses of clonidine were different in the different tests employed, but they were always smaller than those of morphine. Naloxone failed to antagonize the analgesic actions of clonidine but effectively antagonized those of morphine. Phenoxybenzamine also did not alter the inhibition of tail flick-induced by clonidine. Clonidine suppressed morphine withdrawal body shakes in a dose-dependent manner as does morphine. This action of clonidine was not reversed by naloxone. In usual laboratory tests, clonidine appears to be an effective analgesic which antagonizes signs of morphine withdrawal.
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Citations
Cited by
Unnerstall, J. R., Kopajtic, T. A., & Kuhar, M. J. (1984) · Brain Research Reviews · doi:10.1016/0165-0173(84)90030-4 · Cited by 708
Pharmacology of spinal adrenergic systems which modulate spinal nociceptive processing
Yaksh, T. L. (1985) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(85)90537-4 · Cited by 586
Noradrenergic alpha 1 and alpha 2 receptors: light microscopic autoradiographic localization.
Young, W. S., & Kuhar, M. J. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.3.1696 · Cited by 423
Preemptive analgesia I: physiological pathways and pharmacological modalities
Kelly, D. J., Ahmad, M., & Brull, S. J. (2001) · Canadian Journal of Anesthesia/Journal canadien d'anesthésie · doi:10.1007/bf03016591 · Cited by 340
Differential effects of endocannabinoid catabolic inhibitors on morphine withdrawal in mice
Gamage, T. F., Ignatowska-Jankowska, B. M., Muldoon, P. P., Cravatt, B. F., Damaj, M. I., & Lichtman, A. H. (2015) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2014.11.015 · Cited by 40
“Previous studies reported that clonidine reduced morphine withdrawal-induced body shakes, jumping, and paw tremors (Dehpour et al., 2001; Fielding et al., 1978; Valeri et al., 1989), but others have reported that while clonidine reduced the height of naloxone-precipitated withdrawal jumps, it did not affect the number…”
Background
Metadata
- Authors
- Fielding, S., Wilker, J., Hynes, M., Szewczak, M., Novick, W. J., & Lal, H.
- Venue
- The Journal of Pharmacology and Experimental Therapeutics
- Publisher
- Elsevier BV
- Published
- 1978-12
- Volume
- 207
- Issue
- 3
- Pages
- 899-905
- ISSN
- 0022-3565 (ISSN-L)
- OpenAlex
- W2341008676
- Cited by
- 223
- References
- 0
- FWCI
- 17.33
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: A comparison of clonidine with morphine for antinociceptive and antiwithdrawal actions. https://app.cochat.ai/papers/10.1016/s0022-3565(25)31493-x
- The paper
- Fielding, S., Wilker, J., Hynes, M., Szewczak, M., Novick, W. J., & Lal, H. (1978). A comparison of clonidine with morphine for antinociceptive and antiwithdrawal actions. The Journal of Pharmacology and Experimental Therapeutics. https://doi.org/10.1016/s0022-3565(25)31493-x
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
