Differential effects of endocannabinoid catabolic inhibitors on morphine withdrawal in mice

Gamage, Thomas F.; Ignatowska-Jankowska, Bogna M.; Muldoon, Pretal P.; Cravatt, Benjamin F.; Damaj, M. Imad; Lichtman, Aron H.

doi:10.1016/j.drugalcdep.2014.11.015

Cited by 40Cannabis and Cannabinoid ResearchNeurotransmitter Receptor Influence on BehaviorPain Mechanisms and Treatments

Differential effects of endocannabinoid catabolic inhibitors on morphine withdrawal in mice

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Gamage, Thomas F., Ignatowska-Jankowska, Bogna M., Muldoon, Pretal P., Cravatt, Benjamin F., Damaj, M. Imad, Lichtman, Aron H.·2015·Drug and Alcohol Dependence

DOI 10.1016/j.drugalcdep.2014.11.015PMC PMC4295928

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Abstract

Background Inhibition of endocannabinoid catabolic enzymes fatty acid amide hydrolase (FAAH) and/or monoacylglycerol lipase (MAGL) reduces somatic morphine withdrawal signs, but its effects on aversive aspects of withdrawal are unknown. The present study investigated whether Δ(9)-tetrahydrocannabinol (THC), the MAGL inhibitor JZL184, the FAAH inhibitor PF-3845, or the dual FAAH/MAGL inhibitor SA-57 would reduce acquisition of morphine withdrawal-induced conditioned place avoidance (CPA) and jumping.Methods Mice were implanted with placebo or 75 mg morphine pellets, 48 h later injected with naloxone or saline and placed in the conditioning apparatus, and assessed for CPA at 72 h. Subjects were also observed for jumping behavior following naloxone challenge.Results Naloxone (0.056 mg/kg) produced robust CPA in morphine-pelleted, but not placebo-pelleted, mice. Morphine pretreatment prevented the occurrence of withdrawal CPA and withdrawal jumping, while clonidine (an α2 adrenergic receptor agonist) only blocked withdrawal CPA. THC, JZL184, and SA-57 significantly reduced the percentage of mice that jumped during the conditioning session, but did not affect acquisition of withdrawal CPA. PF-3845 did not reduce morphine withdrawal CPA or jumping. Finally, neither THC nor the endocannabinoid catabolic enzyme inhibitors in non-dependent mice elicited a conditioned place preference or aversion.Conclusions These findings suggest that inhibiting endocannabinoid catabolic enzymes reduces somatic morphine withdrawal signs, but not aversive aspects as inferred in the CPA paradigm. The observation that non-dependent mice administered inhibitors of endocannabinoid degradation did not display place preferences is consistent with the idea that that endocannabinoid catabolic enzymes might be targeted therapeutically, with reduced risk of abuse.

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Differential effects of endocannabinoid catabolic inhibitors on opioid withdrawal in mice
Gamage, T. F. (2013) · VCU Scholars Compass (Virginia Commonwealth University) · doi:10.25772/xt10-c161
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Authors: Gamage, T. F., Ignatowska-Jankowska, B. M., Muldoon, P. P., Cravatt, B. F., Damaj, M. I., & Lichtman, A. H.
Affiliations: Virginia Commonwealth University (US)
Scripps Research Institute (US)
Corresponding author: Lichtman, Aron H.
ORCID: Gamage, Thomas F.
Ignatowska-Jankowska, Bogna M.
Cravatt, Benjamin F.
Damaj, M. Imad
Lichtman, Aron H.
Venue: Drug and Alcohol Dependence
Publisher: Elsevier BV
Published: 2015-01
Volume: 146
Pages: 7-16
ISSN: 0376-8716 (ISSN-L)
DOI: 10.1016/j.drugalcdep.2014.11.015
PMC: PMC4295928
OpenAlex: W2020213759
Cited by: 40
References: 88
Citations by year: 2026: 1 · 2025: 3 · 2024: 2 · 2023: 4 · 2022: 1 · 2021: 6 · 2020: 3 · 2019: 5 · 2018: 3 · 2017: 3 · 2016: 8 · 2015: 1
FWCI: 2.91
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Drug and Alcohol Dependence (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Drug Abuse (P01DA009789, P01DA01725, R01DA032933, P01DA017259, T32DA007027)
Topics: Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
Keywords: morphine withdrawal, fatty acid amide hydrolase, monoacylglycerol lipase, JZL184, tetrahydrocannabinol, conditioned place avoidance, jumping behavior, naloxone, clonidine, opioid use disorder, endocannabinoid system
MeSH terms: Acetamides, Fatty Acid Amide Hydrolases, Amidohydrolases, Animals, Avoidance Learning, Carbamates, Conditioning, Psychological, Enzyme Inhibitors, Male, Monoacylglycerol Lipases, Morphine, Naloxone, Piperidines, Pyridines, Substance Withdrawal Syndrome, Dronabinol, Mice, Benzodioxoles, Endocannabinoids

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Differential effects of endocannabinoid catabolic inhibitors on morphine withdrawal in mice

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