The DOI matches its Crossref record; 55 of the 57 references it cites were found in a registry or an index.
Comparison of regional cerebral blood flow and glucose metabolism in the normal brain: effect of aging
Abstract
The regional cerebral blood flow (rCBF) and metabolic rate for glucose (rCMRGlc) are associated with functional activity of the neural cells. The present work reports a comparison study between rCBF and rCMRGlc in a normal population as a function of age. 10 young (25.9+/-5.6 years) and 10 old (65.4+/-6.1 years) volunteers were similarly studied at rest. In each subject, rCBF and rCMRGlc were measured in sequence, during the same session. Both rCBF and rCMRGlc values were found to decrease from young (mean rCBF=43.7 ml/100 g per min; mean rCMRGlc=40.6 micromol/100 g per min) to old age (mean rCBF=37.3 ml/100 g per min; mean rCMRGlc=35.2 micromol/100 g per min), resulting in a drop over 40 years of 14.8% (0.37%/year) and 13.3% (0.34%/year), respectively. On a regional basis, the frontal and the visual cortices were observed to have, respectively, the highest and the lowest reduction in rCBF, while, for rCMRGlc, these extremes were observed in striatum and cerebellum. Despite these differences, the ratio of rCBF to rCMRGlc was found to have a similar behavior in all brain regions for young and old subjects as shown by a correlation coefficient of 88%. This comparative study indicates a decline in rCBF and rCMRGlc values and a coupling between CBF and CMRGlc as a function of age.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Brain glucose metabolism significantly declines in old age 186”
From Hormonal and Metabolic Changes of Aging and the Influence of Lifestyle Modifications (2021) · cites this paper as [186]
Citations
Cites
Co-Planar Stereotaxic Atlas of the Human Brain
Talairach, J., & Tournoux, P. (1988) · Medical Entomology and Zoology · Cited by 11,798
Co-planar stereotaxic atlas of the human brain
Laitinen, L. (1989) · Clinical Neurology and Neurosurgery · doi:10.1016/0303-8467(89)90128-5 · Cited by 7,565
Minuit - a system for function minimization and analysis of the parameter errors and correlations
James, F., & Roos, M. (1975) · Computer Physics Communications · doi:10.1016/0010-4655(75)90039-9 · Cited by 3,274
Synaptic density in human frontal cortex —Developmental changes and effects of aging
Peter R., H. (1979) · Brain Research · doi:10.1016/0006-8993(79)90349-4 · Cited by 2,645
Phelps, M. E., Huang, S. C., Hoffman, E. J., Selin, C. E., Sokoloff, L., & Kuhl, D. E. (1979) · Annals of Neurology · doi:10.1002/ana.410060502 · Cited by 2,417
Frackowiak, R. S. J., Lenzi, G.-L., Jones, T., & Heather, J. D. (1980) · Journal of Computer Assisted Tomography · doi:10.1097/00004728-198012000-00001 · Cited by 1,241
CEREBRAL BLOOD FLOW, BLOOD VOLUME AND OXYGEN UTILIZATION
Leenders, K. L., Perani, D., Lammertsma, A. A., Heather, J. D., Buckingham, P. D., Jones, T., Healy, M. J. R., GIBBS, J. M., WISE, R. J. S., Hatazawa, J., et al. (1990) · Brain · doi:10.1093/brain/113.1.27 · Cited by 1,094
Brain blood flow measured with intravenous H2(15)O. II. Implementation and validation.
Raichle, M. E., Martin, W. R. W., Herscovitch, P., Mintun, M. A., & Markham, J. (1983) · PubMed · Cited by 1,015
Neocortical cell counts in normal human adult aging
Terry, R. D., DeTeresa, R. M., & Hansen, L. A. (1987) · Annals of Neurology · doi:10.1002/ana.410210603 · Cited by 686
Wienhard, K., Dahlbom, M. L., Eriksson, L., Michel, C. J., Bruckbauer, T., Pietrzyk, U., & Heiss, W. (1994) · Journal of Computer Assisted Tomography · doi:10.1097/00004728-199401000-00023 · Cited by 561
Self-citationDendritic Growth in the Aged Human Brain and Failure of Growth in Senile Dementia
Buell, S. J., & Coleman, P. D. (1979) · Science · doi:10.1126/science.493989 · Cited by 475
Quantitative synaptic alterations in the human neocortex during normal aging
Masliah, E., Mallory, M. E., Hansen, L. A., DeTeresa, R. M., & Terry, R. D. (1993) · Neurology · doi:10.1212/wnl.43.1_part_1.192 · Cited by 408
McHenry, L. C. (1966) · New England Journal of Medicine · doi:10.1056/nejm196601132740206 · Cited by 372
Progressive dendritic changes in aging human cortex
Scheibel, M. E., Lindsay, R. D., Tomiyasu, U., & Scheibel, A. B. (1975) · Experimental Neurology · doi:10.1016/0014-4886(75)90072-2 · Cited by 365
Kuhl, D. E., Metter, E. J., Riege, W. H., & Phelps, M. E. (1982) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1982.15 · Cited by 338
Kadekaro, M., Crane, A. M., & Sokoloff, L. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.17.6010 · Cited by 337
Pietrzyk, U., Herholz, K., Fink, G. R., Jacobs, A., Mielke, R., Slansky, I., Würker, M., & Heiss, W. (1994) · PubMed · Cited by 318
Horwitz, B., Duara, R., & Rapoport, S. I. (1984) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1984.73 · Cited by 314
Human brain glucose utilization and cognitive function in relation to age
Duara, R., PhD, C. G., PhD, J. H., Ingvar, D. H., Sokoloff, L., Margolin, R. A., PhD, R. G. M., Cutler, N. R., & Рапопорт, С. И. (1984) · Annals of Neurology · doi:10.1002/ana.410160613 · Cited by 262
Duara, R., Margolin, R. A., Robertson‐Tchabo, E. A., London, E. D., Schwartz, M. L., Renfrew, J. W., Koziarz, B., Sundaram, M., GRADY, C., Moore, A. M., et al. (1983) · Brain · doi:10.1093/brain/106.3.761 · Cited by 228
Heiss, W., Pawlik, G., Herholz, K., Wagner, R. L., Göldner, H. J., & Wienhard, K. (1984) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1984.30 · Cited by 210
GJEDDE, A. H., Wienhard, K., Heiss, W., Kloster, G., Diemer, N. H., Herholz, K., & Pawlik, G. (1985) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1985.23 · Cited by 181
Yoshii, F., Barker, W. W., Chang, J. Y., Loewenstein, D., Apicella, A., Smith, D. D., Boothe, T. E., Ginsberg, M. D., Pascal, S., & Duara, R. (1988) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1988.112 · Cited by 168
Cerebral glucose metabolic rates in normal human females versus normal males
Baxter, L. R., Mazziotta, J. C., Phelps, M. E., Selin, C. E., Guzé, B. H., & Fairbanks, L. A. (1987) · Psychiatry Research · doi:10.1016/0165-1781(87)90028-x · Cited by 166
The Effect of Anxiety on Cortical Cerebral Blood Flow and Metabolism
Gur, R. C., Gur, R. E., Resnick, S. M., Skolnick, B. E., Alavi, A. A., & Reivich, M. (1987) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1987.40 · Cited by 159
Liu, X., Erikson, C., & Brun, A. E. (1996) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000106867 · Cited by 152
Neuroanatomy and Cranial Computed Tomography
Hj, K., & Weinrich, W. (1986) · Medical Entomology and Zoology · Cited by 140
Reproducibility of Cerebral Glucose Metabolic Measurements in Resting Human Subjects
Bartlett, E. J., Brodie, J. D., Wolf, A. P., Christman, D. R., LASKA, E. M., & Meissner, M. (1988) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1988.91 · Cited by 136
Brain Glucose Metabolism in Postanoxic Syndrome
Devolder, A. (1990) · Archives of Neurology · doi:10.1001/archneur.1990.00530020103022 · Cited by 130
Self-citationBrain energy metabolism in early blind subjects: neural activity in the visual cortex
Volder, A. D., Bol, A., Blin, J., Robert, A. R., Arno, P., Grandin, C. B. G., Michel, C. J., & Veraart, C. (1997) · Brain Research · doi:10.1016/s0006-8993(96)01352-2 · Cited by 125
Self-citationBertoni–Freddari, C., Fattoretti, P., Casoli, T., Meier-Ruge, W. A., & ULRICH, J. (1990) · Brain Research · doi:10.1016/0006-8993(90)91009-6 · Cited by 121
Age differences in intercorrelations between regional cerebral metabolic rates for glucose
Horwitz, B., Duara, R., & Rapoport, S. I. (1986) · Annals of Neurology · doi:10.1002/ana.410190111 · Cited by 103
Positron Emission Tomography and Computed Tomography Assessments of the Aging Human Brain
de Leon, M. J., GEORGE, A. E., Ferris, S. H., Christman, D. R., Fowler, J. S., Gentes, C. I., Brodie, J. D., Reisberg, ., & Wolf, A. P. (1984) · Journal of Computer Assisted Tomography · doi:10.1097/00004728-198402000-00017 · Cited by 97
Intersubject variability of brain glucose metabolic measurements in young normal males.
Wang, G., Volkow, N. D., Wolf, A. P., Brodie, J. D., & HITZEMANN, R. J. (1994) · PubMed · Cited by 87
Knudsen, G. M., Paulson, O. B., & Hertz, M. M. (1991) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1991.107 · Cited by 84
Tyler, J. L., Strother, S. C., Zatorre, R. J., Alivisatos, B., Worsley, K. J., Dikšić, M., & Yamamoto, Y. (1988) · PubMed · Cited by 80
Hawkins, R. A., Mazziotta, J. C., Phelps, M. E., Huang, S., Kuhl, D. E., Carson, R. E., Metter, E. J., & Riege, W. H. (1983) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1983.34 · Cited by 77
Photic Stimulation Study of Changing the Arterial Partial Pressure Level of Carbon Dioxide
Shimosegawa, E., Kanno, I., Hatazawa, J., Fujita, H., Iida, H., Miura, S., Murakami, M., Inugami, A., Ogawa, T., Itoh, H., et al. (1995) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1995.12 · Cited by 75
Matthew, E. M., Andreason, P., Carson, R. E., Herscovitch, P., Pettigrew, K. D., Cohen, R. M., King, C., Johanson, C., & Paul, S. M. (1993) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1993.95 · Cited by 74
Gender differences in correlations of cerebral glucose matabolic rates in young normal adults
Azari, N. P., Рапопорт, С. И., Grady, C. L., DeCarli, C. S., Haxby, J. V., Schapiro, M. B., & Horwitz, B. (1992) · Brain Research · doi:10.1016/0006-8993(92)90817-s · Cited by 59
Miura, S., Schapiro, M. B., Grady, C. L., Kumar, A., Salerno, J. A., Kozachuk, W. E., Wagner, E., Рапопорт, С. И., & Horwitz, B. (1990) · Journal of Neuroscience Research · doi:10.1002/jnr.490270410 · Cited by 55
Maquet, P., Dive, D., Salmon, É., von Frenckel, R., & Franck, G. (1990) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/bf00842779 · Cited by 53
Horwitz, B. (1990) · International Journal of Bio-Medical Computing · doi:10.1016/0020-7101(90)90039-w · Cited by 52
Junck, L., Gilman, S., Rothley, J., Betley, A. T., Koeppe, R. A., & Hichwa, R. D. (1988) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1988.132 · Cited by 51
Optimizing rod window width in positron emission tomography
Jones, W. F., Digby, W. M., Luk, W. K., Casey, M. E., & Byars, L. G. (1995) · IEEE Transactions on Medical Imaging · doi:10.1109/42.387708 · Cited by 51
Adams, I. (1987) · Brain Research · doi:10.1016/0006-8993(87)91479-x · Cited by 44
Functional Interactions in the Brain: Use of Correlations between Regional Metabolic Rates
Horwitz, B. (1991) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1991.46 · Cited by 41
Camargo, E. E., Szabó, Z. R., Links, J. M., Sostre, S., Dannals, R. F., & Wagner, H. N. (1992) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1992.38 · Cited by 40
Mediman: an object oriented programming approach for medical image analysis
Coppens, A., Sibomana, M., Bol, A., & Michel, C. J. (1993) · IEEE Transactions on Nuclear Science · doi:10.1109/23.256691 · Cited by 31
Self-citationThe Lumped Constant in the Deoxyglucose Procedure Declines with Age in Fischer‐344 Rats
Takei, H., Fredericks, W. R., & Rapoport, S. I. (1986) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1986.tb13059.x · Cited by 25
Bol, A., Vanmelckenbeke, P., Michel, C. J., Cogneau, M., & Goffinet, A. M. (1990) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/bf00812363 · Cited by 24
Self-citationNeuroanatomy and cranial computed tomography
Ball, M. R. (1987) · Surgical Neurology · doi:10.1016/0090-3019(87)90121-2 · Cited by 23
Interactive delineation of brain sulci and their merging into functional PET images
Michel, C. J., Sibomana, M., Bodart, J.-M., Grandin, C. B. G., Coppens, A., Bol, A., Volder, A. D., Warscotte, V., Thiran, J., & Macq, B. M. M. (2002) · IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC) · doi:10.1109/nssmic.1995.500306 · Cited by 20
Self-citationReutens, D. C., GJEDDE, A. H., & Meyer, E. (1998) · PubMed · Cited by 15
The FDG model and its application in clinical PET studies
Wienhard, K. (1992) · Springer eBooks · doi:10.1007/978-3-7091-9209-2_4 · Cited by 9
Research works printed but not linked: 2
- Raichle, 1983, Brain blood flow measured with intravenous H215O. II. Implementation and validation, J Nucl Med, 24, 790
- Lammertsma, 1981, Accuracy of the oxygen-15 steady state technique for measuring rCBF and rCMRO2: tracer modelling, statistics and spatial sampling, J Cereb Blood Flow Metab, 1, S1
Cited by
Sorted by citations
Pathophysiology of Sleep Apnea
Dempsey, J. A., Veasey, S. C., Morgan, B. J., & O'Donnell, C. P. (2010) · Physiological Reviews · doi:10.1152/physrev.00043.2008 · Cited by 2,243
Alterations in the BOLD fMRI signal with ageing and disease: a challenge for neuroimaging
D’Esposito, M., Deouell, L. Y., & Gazzaley, A. H. (2003) · Nature reviews. Neuroscience · doi:10.1038/nrn1246 · Cited by 852
Raz, N., Gunning‐Dixon, F. M., Head, D. M., Rodrigue, K. M., Williamson, A. L., & Acker, J. D. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(03)00118-0 · Cited by 748
Head, D. (2004) · Cerebral Cortex · doi:10.1093/cercor/bhh003 · Cited by 645
Brain fuel metabolism, aging, and Alzheimer’s disease
Cunnane, S. C., Nugent, S., Roy, M., Courchesne‐Loyer, A., Croteau, É., Tremblay, S., Castellano, A., Pifferi, F., Bocti, C., Paquet, N., et al. (2010) · Nutrition · doi:10.1016/j.nut.2010.07.021 · Cited by 633
Self-citation
Metadata
- Authors
- Bentourkia, M., Bol, A., Ivanoiu, A., Labar, D., Sibomana, M., Coppens, A., Michel, C., Cosnard, G., & De Volder, A. G.
- Affiliations
- UCLouvain (BE)
- Venue
- Journal of the Neurological Sciences
- Publisher
- Elsevier BV
- Published
- 2000-12
- Volume
- 181
- Issue
- 1-2
- Pages
- 19-28
- ISSN
- 0022-510X (ISSN-L)
- OpenAlex
- W1963947389
- Cited by
- 189
- References
- 57
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 10 · 2023: 8 · 2022: 10 · 2021: 14 · 2020: 9 · 2019: 12 · 2018: 11 · 2017: 6 · 2016: 8 · 2015: 9 · 2014: 4 · 2013: 11 · 2012: 9
- FWCI
- 3.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the Neurological Sciences (publishedVersion)
- PubMed (publishedVersion)
- DIAL (Catholic University of Leuven) (submittedVersion)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Keywords
- regional cerebral blood flow, brain glucose metabolism, aging, brain aging, frontal cortex, visual cortex, striatum, cerebellum, regional brain metabolism, normal brain
- MeSH terms
- Adult, Aged, Aging, Brain, Cerebrovascular Circulation, Female, Glucose, Humans, Male, Middle Aged, Tomography, Emission-Computed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
