The DOI matches its Crossref record; 55 of the 57 references it cites were found in a registry or an index.
Comparison of regional cerebral blood flow and glucose metabolism in the normal brain: effect of aging
Abstract
The regional cerebral blood flow (rCBF) and metabolic rate for glucose (rCMRGlc) are associated with functional activity of the neural cells. The present work reports a comparison study between rCBF and rCMRGlc in a normal population as a function of age. 10 young (25.9+/-5.6 years) and 10 old (65.4+/-6.1 years) volunteers were similarly studied at rest. In each subject, rCBF and rCMRGlc were measured in sequence, during the same session. Both rCBF and rCMRGlc values were found to decrease from young (mean rCBF=43.7 ml/100 g per min; mean rCMRGlc=40.6 micromol/100 g per min) to old age (mean rCBF=37.3 ml/100 g per min; mean rCMRGlc=35.2 micromol/100 g per min), resulting in a drop over 40 years of 14.8% (0.37%/year) and 13.3% (0.34%/year), respectively. On a regional basis, the frontal and the visual cortices were observed to have, respectively, the highest and the lowest reduction in rCBF, while, for rCMRGlc, these extremes were observed in striatum and cerebellum. Despite these differences, the ratio of rCBF to rCMRGlc was found to have a similar behavior in all brain regions for young and old subjects as shown by a correlation coefficient of 88%. This comparative study indicates a decline in rCBF and rCMRGlc values and a coupling between CBF and CMRGlc as a function of age.
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“Brain glucose metabolism significantly declines in old age 186”
From Hormonal and Metabolic Changes of Aging and the Influence of Lifestyle Modifications (2021) · cites this paper as [186]
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Cites
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Metadata
- Authors
- Bentourkia, M., Bol, A., Ivanoiu, A., Labar, D., Sibomana, M., Coppens, A., Michel, C., Cosnard, G., & De Volder, A. G.
- Affiliations
- UCLouvain (BE)
- Venue
- Journal of the Neurological Sciences
- Publisher
- Elsevier BV
- Published
- 2000-12
- Volume
- 181
- Issue
- 1-2
- Pages
- 19-28
- ISSN
- 0022-510X (ISSN-L)
- OpenAlex
- W1963947389
- Cited by
- 189
- References
- 57
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 10 · 2023: 8 · 2022: 10 · 2021: 14 · 2020: 9 · 2019: 12 · 2018: 11 · 2017: 6 · 2016: 8 · 2015: 9 · 2014: 4 · 2013: 11 · 2012: 9
- FWCI
- 3.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the Neurological Sciences (publishedVersion)
- PubMed (publishedVersion)
- DIAL (Catholic University of Leuven) (submittedVersion)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Keywords
- regional cerebral blood flow, brain glucose metabolism, aging, brain aging, frontal cortex, visual cortex, striatum, cerebellum, regional brain metabolism, normal brain
- MeSH terms
- Adult, Aged, Aging, Brain, Cerebrovascular Circulation, Female, Glucose, Humans, Male, Middle Aged, Tomography, Emission-Computed
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