The DOI matches its Crossref record; 36 of the 38 references it cites were found in a registry or an index.
On the origin of the transfer RNA molecule
Abstract
Data and arguments are given in favour of the hypothesis that the primitive tRNA molecule may have originated from a direct duplication event involving one of the two halves of the tRNA molecule. It seems that a molecule capable of assuming a hairpin structure was involved as a precursor in this duplication. The two halves of the present tRNAs could, therefore, be considered as paralogous.
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“Among the 20 amino acids in the universal code, approximately half came from the prebiotic soup; as we see in the SNS code, the remaining half of amino acids were derivatives of the first set of 10 primitive amino acids by biosynthesis [78].”
From The Origin of Prebiotic Information System in the Peptide/RNA World: A Simulation Model of the Evolution of Translation and the Genetic Code (2019) · cites this paper as [78]
Citations
Cites
Toward Defining the Course of Evolution: Minimum Change for a Specific Tree Topology
Fitch, W. M. (1971) · Systematic Biology · doi:10.1093/sysbio/20.4.406 · Cited by 7,727
Toward Defining the Course of Evolution: Minimum Change for a Specific Tree Topology
Fitch, W. M. (1971) · Systematic Zoology · doi:10.2307/2412116 · Cited by 5,661
Atlas of protein sequence and structure
Chang, M.-Y., Dayhoff, M. O., Eck, R. V., & Sochard, M. R. (1965) · NASA Technical Reports Server (NASA) · Cited by 4,383
Atlas of Protein Sequence and Structure, 1972.
Fitch, W. M., & Dayhoff, M. O. (1973) · Systematic Zoology · doi:10.2307/2412105 · Cited by 2,454
Compilation of tRNA sequences and sequences of tRNA genes
Sprinzl, M. (2004) · Nucleic Acids Research · doi:10.1093/nar/gki012 · Cited by 1,916
Statistical Methods for Research Workers
Tukey, J. W., & Fisher, R. A. (1952) · Econometrica · doi:10.2307/1907425 · Cited by 950
Statistical Methods for Research Workers
H., F. Z. (1930) · Agronomy Journal · doi:10.2134/agronj1930.00021962002200120009x · Cited by 679
Homology in classical and molecular biology.
Patterson, C. (1988) · Molecular Biology and Evolution · doi:10.1093/oxfordjournals.molbev.a040523 · Cited by 433
Genes in pieces: were they ever together?
Doolittle, W. F. (1978) · Nature · doi:10.1038/272581a0 · Cited by 431
Gilbert, W., Marchionni, M. A., & McKnight, G. L. (1986) · Cell · doi:10.1016/0092-8674(86)90730-0 · Cited by 322
Research works printed but not linked: 1
- Winkler-Oswatitsch, 1986, Comparative sequence analysis. Exemplified with tRNA and 5S rRNA, Chemical Scripta., 26B, 59
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Rodin, S. N., & Rodin, A. S. (2007) · Springer eBooks · doi:10.1007/978-0-387-68656-1_19 · Cited by 2
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Wei, F., Mao, Y., & Lan, Z. (2015) · Advances in Bioscience and Biotechnology · doi:10.4236/abb.2015.611070
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White, B. A. (2019) · OakTrust (Texas A&M University Libraries)
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Chauvet, G. A. (1986) · Elsevier eBooks · doi:10.1016/b978-0-08-041992-3.50031-7
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Caetano‐Anollés, G. (2026) · Springer eBooks · doi:10.1007/978-3-032-24295-2_17
Mandal, U. R., Maity, K., & DAS, S. (2026) · Research Square · doi:10.21203/rs.3.rs-9880424/v1
Metadata
- Authors
- Giulio, M. D.
- Affiliations
- Institute of Genetics and Biophysics (IT)
- Corresponding author
- Giulio, Massimo Di
- ORCID
- Giulio, Massimo Di
- Venue
- Journal of Theoretical Biology
- Publisher
- Elsevier BV
- Published
- 1992-11
- Volume
- 159
- Issue
- 2
- Pages
- 199-214
- ISSN
- 0022-5193 (ISSN-L)
- OpenAlex
- W1968532770
- Cited by
- 131
- References
- 38
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 3 · 2023: 5 · 2022: 9 · 2021: 4 · 2020: 5 · 2019: 6 · 2018: 6 · 2017: 5 · 2016: 3 · 2015: 11 · 2014: 5 · 2013: 6 · 2012: 7
- FWCI
- 0.13
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Theoretical Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Physical Sciences › Physics and Astronomy › Astronomy and Astrophysics › Origins and Evolution of Life
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA modifications and cancer
- Keywords
- tRNA, molecular evolution, gene duplication, hairpin structure, paralogs, tRNA structure
- MeSH terms
- Amino Acid Sequence, Animals, Biological Evolution, Models, Genetic, Molecular Sequence Data, RNA, Transfer, Sequence Homology
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