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Is resection of pulmonary and hepatic metastases warranted in patients with colorectal cancer?
Open accessAbstract
Background Conventional management of stage IV colorectal carcinoma is palliative. The value of resecting both liver and lung colorectal metastases that occur in isolation of other sites of metastasis is undetermined.Objectives Our objectives were to (1) assess the efficacy of resecting both hepatic and pulmonary metastases, (2) investigate the influence of the sequence and timing of metastases, and (3) identify the profile of patients likely to benefit from both hepatic and pulmonary metastasectomy.Patients and methods Of 48 patients identified with resection of colorectal cancer and, at some point in time, both liver and lung metastases, 25 patients underwent metastasectomy (resection group). The remaining 23 patients comprised the nonresection group. Risk factors for death were identified by multivariable analyses.Results Median survival was longer after the last metastatic appearance in the resection group (16 months) than in the nonresection group (6 months; P <.001). The pattern of risk also differed; it peaked at 2 years and then declined in the resection group but was constant in the nonresection group. In the resection group, patients with metachronous resections survived longer after colorectal resection (median, 70 months) than patients with synchronous (median, 22 months) or mixed resections (median, 31 months; P <.001). Risk factors for death included older age, multiple liver metastases, and a short disease-free interval.Conclusions Younger patients with solitary metachronous metastases to the liver, then the lung, and long disease-free intervals are more likely to benefit from resection of both liver and lung metastases. Patients with risk factors also had better survival with resection than without resection.
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“There are reports showing the efficacy of hepatectomy in patients who have controllable extrahepatic metastases (mainly lung metastases) in addition to liver metastases [35, 36, 39, 43] (CQ-7).”
From Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines 2016 for the treatment of colorectal cancer (2018) · cites this paper as [39]
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Citations
Cites
Nonparametric Estimation from Incomplete Observations
Kaplan, E. L., & Meier, P. (1992) · Springer series in statistics · doi:10.1007/978-1-4612-4380-9_25 · Cited by 45,239
Regression Models and Life-Tables
Cox, D. R. (1972) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1972.tb00899.x · Cited by 39,793
Nonparametric Estimation from Incomplete Observations
Kaplan, E. L., & Meier, P. (1958) · Journal of the American Statistical Association · doi:10.1080/01621459.1958.10501452 · Cited by 39,158
Regression Models and Life-Tables
Cox, D. R. (1992) · Springer Series in Statistics · doi:10.1007/978-1-4612-4380-9_37 · Cited by 26,297
Blackstone, E. H., Naftel, D. C., & Turner, M. E. (1986) · Journal of the American Statistical Association · doi:10.1080/01621459.1986.10478314 · Cited by 646
Self-citationBootstrap investigation of the stability of a cox regression model
Altman, D. G., & Andersen, P. K. (1989) · Statistics in Medicine · doi:10.1002/sim.4780080702 · Cited by 311
Surgery for lung metastases from colorectal cancer: analysis of prognostic factors.
Girard, P., Ducreux, M. P., Baldeyrou, P., Rougier, P. R., Chevalier, T. L., Bougaran, J., Lasser, P., Gayet, B., Ruffiè, P., & Grunenwald, D. H. (1996) · Journal of Clinical Oncology · doi:10.1200/jco.1996.14.7.2047 · Cited by 185
Long-term effects of testicular cancer on sexual functioning in married couples
Gritz, E. R., Wellisch, D. K., Wang, H.-J., Siau, J., Landsverk, J. A., & Cosgrove, M. D. (1989) · Cancer · doi:10.1002/1097-0142(19891001)64:7 · Cited by 86
Repeat hepatic resections for colorectal metastases.
Griffith, K. D., Sugarbaker, P. H., & Chang, A. E. (1990) · PubMed · Cited by 86
Results of pulmonary resection of metastatic colorectal cancer and its application
Yano, T., Hara, N., Ichinose, Y., Yokoyama, H., Miura, T., & Ohta, M. (1993) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/s0022-5223(19)34042-5 · Cited by 80
Research works printed but not linked: 1
- Äberg, 1997, Selection mechanisms as major determinants of survival after pulmonary metastasectomy, Ann Thorac Surg, 63, 611
Cited by
Sorted by citations
Japanese Society for Cancer of the Colon and Rectum, Watanabe, T., Muro, K., Ajioka, Y., Hashiguchi, Y., Ito, Y., Saito, Y., Hamaguchi, T., Ishida, H., Ishiguro, M., et al. (2018) · International Journal of Clinical Oncology · doi:10.1007/s10147-017-1101-6 · Cited by 2,467
“1 There are reports showing the efficacy of hepatectomy in patients who have controllable extrahepatic metastases (mainly lung metastases) in addition to liver metastases [35, 36, 39, 43] (CQ-7).”
BackgroundHashiguchi, Y., Muro, K., Saitō, Y., Ito, Y., Ajioka, Y., Hamaguchi, T., Hasegawa, K., Hotta, K., Ishida, H., Ishiguro, M., et al. (2019) · International Journal of Clinical Oncology · doi:10.1007/s10147-019-01485-z · Cited by 1,950
“• If recurrence is observed in more than a single organ, resection can be considered if the recurrent tumors in all the organs are resectable [59, 61].”
BackgroundJapanese Society for Cancer of the Colon and Rectum, Watanabe, T., Itabashi, M., Shimada, Y., Tanaka, S., Ito, Y., Ajioka, Y., Hamaguchi, T., Hyodo, I., Igarashi, M., et al. (2011) · International Journal of Clinical Oncology · doi:10.1007/s10147-011-0315-2 · Cited by 706
“• There are reports showing the efficacy of hepatectomy in patients who have controllable extrahepatic metastases (mainly lung metastases) in addition to liver metastases [12, 13, 15, 16] (CQ-7).”
BackgroundMinagawa, M., Makuuchi, M., Torzilli, G., Takayama, T., Kawasaki, S., Kosuge, T., Yamamoto, J., & Imamura, H. (2000) · Annals of Surgery · doi:10.1097/00000658-200004000-00006 · Cited by 661
Watanabe, T., Itabashi, M., Shimada, Y., Tanaka, S., Ito, Y., Ajioka, Y., Hamaguchi, T., Hyodo, I., Igarashi, M., Ishida, H., et al. (2015) · International Journal of Clinical Oncology · doi:10.1007/s10147-015-0801-z · Cited by 596
“• If recurrence is observed in more than a single organ, resection can be considered if the recurrent tumors in all of the organs are resectable [35, 39]; however, Fig.”
BackgroundMitry, E., Guiu, B., Cosconea, S., Jooste, V., Faivre, J., & Bouvier, A. (2010) · Gut · doi:10.1136/gut.2010.211557 · Cited by 379
“Some authors have found better results in metachronous versus synchronous metastases,”
ResultBenefits of surgery for patients with pulmonary metastases from colorectal carcinoma
Inoue, M., Ohta, M., Iuchi, K., Matsumura, A., Ideguchi, K., Yasumitsu, T., Nakagawa, K., Fukuhara, K., Maeda, H., Takeda, S., et al. (2004) · The Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2004.02.017 · Cited by 286
Surgical Resection of Hepatic and Pulmonary Metastases from Colorectal Carcinoma
Shah, S. A., Haddad, R., Al-Sukhni, W., Kim, R. D., Greig, P. D., Grant, D. R., Taylor, B., Langer, B., Gallinger, S., & Wei, A. C.-C. (2006) · Journal of the American College of Surgeons · doi:10.1016/j.jamcollsurg.2005.11.008 · Cited by 270
Pfannschmidt, J., Muley, T., Hoffmann, H., & Dienemann, H. (2003) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/s0022-5223(03)00587-7 · Cited by 251
Surgical treatment of hepatic and pulmonary metastases from colon cancer
Headrick, J. R., Miller, D. L., Nagorney, D. M., Allen, M. S., Deschamps, C. C., Trastek, V. F., & Pairolero, P. C. (2001) · The Annals of Thoracic Surgery · doi:10.1016/s0003-4975(00)02522-4 · Cited by 241
“Prognostic variables such as prethoracotomy CEA level, age, number of metastatic lesions, disease-free interval, and synchronous versus metachronous lesions have all been identified as affecting survival [5, 11, 12, 14, 16, 22, 23].”
BackgroundResultAltendorf-Hofmann, A., & Scheele, J. (2003) · Surgical Oncology Clinics of North America · doi:10.1016/s1055-3207(02)00091-1 · Cited by 183
“Similarly, the current authors would pursue resection in patients with resectable local recurrence and limited lung metastases [131–134].”
BackgroundSurvival After Resection of Multiple Hepatic Colorectal Metastases
Weber, S. M., Jarnagin, W. R., DeMatteo, R. P., Blumgart, L. H., & Fong, Y. (2000) · Annals of Surgical Oncology · doi:10.1007/s10434-000-0643-3 · Cited by 180
Surgical treatment for both pulmonary and hepatic metastases from colorectal cancer
Kobayashi, K., Kawamura, M., & Ishihara, T. (1999) · The Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/s0022-5223(99)70106-6 · Cited by 152
Surgical treatment of liver metastases
Sasson, A. R., & Sigurdson, E. R. (2002) · Seminars in Oncology · doi:10.1053/sonc.2002.31676 · Cited by 129
Management of colorectal liver metastases
Fusai, G., & Davidson, B. R. (2003) · Colorectal Disease · doi:10.1046/j.1463-1318.2003.00410.x · Cited by 113
Surgical management of patients with colorectal cancer and simultaneous liver and lung metastases
Andrès, A., Mentha, G., Adam, R. A., Gerstel, E., Скипенко, О. Г., Barroso, E., López‐Ben, S., Hubert, C., Majno, P. E., & Toso, C. (2015) · British journal of surgery · doi:10.1002/bjs.9783 · Cited by 108
Quan, D., Gallinger, S., Nhan, C., Auer, R. C., Biagi, J. J., Fletcher, G. G., Law, C., Moulton, C.-A. E., Ruo, L., Wei, A. C.-C., et al. (2012) · Surgery · doi:10.1016/j.surg.2011.12.018 · Cited by 104
Percutaneous radiofrequency ablation of pulmonary metastases in patients with colorectal cancer
King, J., Glenn, D. W., Clark, W. A., Zhao, J., Steinke, K., Clingan, P. R., & Morris, D. L. (2004) · British journal of surgery · doi:10.1002/bjs.4392 · Cited by 98
Hadden, W. J., de Reuver, P. R., Brown, K. M., Mittal, A., Samra, J. S., & Hugh, T. J. (2016) · HPB · doi:10.1016/j.hpb.2015.12.004 · Cited by 96
Mineo, T. C., Ambrogi, V., Tonini, G., Bollero, P., Roselli, M., Mineo, D., & Nofroni, I. (2003) · Journal of the American College of Surgeons · doi:10.1016/s1072-7515(03)00387-9 · Cited by 92
Simultaneous Detection of Colorectal Carcinoma Liver and Lung Metastases Does Not Warrant Resection
Nagakura, S., Shirai, Y., Yamato, Y., Yokoyama, N., Suda, T., & Hatakeyama, K. (2001) · Journal of the American College of Surgeons · doi:10.1016/s1072-7515(01)00970-x · Cited by 83
Kinugasa, Y., Uehara, K., Yamaguchi, K., Saito, Y., Murofushi, K. N., Sugai, T., Ishiguro, M., Ishihara, S., Ueno, H., Oka, S., et al. (2025) · International Journal of Clinical Oncology · doi:10.1007/s10147-025-02899-8 · Cited by 99
Indications and approach to surgical resection of lung metastases
Kaifi, J. T., Gusani, N. J., Deshaies, I., Kimchi, E. T., Reed, M. F., Mahraj, R. P. M., & Staveley-O’Carroll, K. F. (2010) · Journal of Surgical Oncology · doi:10.1002/jso.21596 · Cited by 79
“Taken together, resectable or resected liver metastases might not impact the survival after pulmonary metastasectomy [45,47,58].”
BackgroundModern multimodality approach to hepatic colorectal metastases: Solutions and controversies
Khatri, V. P., Chee, K. G., & Petrelli, N. J. (2007) · Surgical Oncology · doi:10.1016/j.suronc.2007.05.001 · Cited by 77
“[46] reported that pulmonary metastasectomy altered the survival curve with a peak survival at 2 years after metastases resection before a decline in the resection group vs.”
BackgroundPulmonary metastasectomy for colorectal cancer: How many nodules, how many times?
Kim, H. K. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i20.6133 · Cited by 72
FDG-PET improves the staging and selection of patients with recurrent colorectal cancer
Lonneux, M., Reffad, A., Detry, R. J., Kartheuser, A. H., Gigot, J., & Pauwels, S. (2002) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-002-0802-9 · Cited by 65
“Recent reports on recurrent colorectal cancer favour an aggressive surgical approach whenever possible because of the non-negligible long-term survival rate [22, 23, 24 ].”
BackgroundCurrent Management of Colorectal Liver Metastases
Martin, L. W., & Warren, R. S. (2000) · Surgical Oncology Clinics of North America · doi:10.1016/s1055-3207(18)30126-1 · Cited by 63
Flor, R. E., Fiorentino, F., Treasure, T., Rivas, J. J., & Molins, L. (2013) · BMJ Open · doi:10.1136/bmjopen-2013-002787 · Cited by 62
“24 An innovative analysis from the Cleveland Clinic of patients who have had hepatic resection for metastases, and subsequently were found to have lung metastases, was used to argue in favour of resection of both, but in very highly selected patients.(25) However, the shape of the survival curve is unlike that of usua…”
Surgical Management of Colorectal Lung Metastasis
Villeneuve, P. J., & Sundaresan, R. (2009) · Clinics in Colon and Rectal Surgery · doi:10.1055/s-0029-1242463 · Cited by 55
“Factors predictive of good outcome included younger age, solitary metachronous liver metastases preceding lung metastases, and a long disease-free interval.(45) In these cases, assessment by a hepatobiliary surgeon in the context of multidisciplinary cancer care is recommended; close consultation is required to decide…”
BackgroundClinical reports of pulmonary metastasectomy for colorectal cancer: a citation network analysis
Fiorentino, F., Vasilakis, C., & Treasure, T. (2011) · British Journal of Cancer · doi:10.1038/sj.bjc.6606060 · Cited by 51
Pulmonary metastasectomy in colorectal cancer: Time for a trial
Treasure, T., Fallowfield, L. J., Farewell, V. T., Ferry, D., Lees, B., Leonard, P., Macbeth, F. R., & Utley, M. (2009) · European Journal of Surgical Oncology · doi:10.1016/j.ejso.2008.12.005 · Cited by 49
“One concerns a meticulous mathematical analysis of patients who underwent liver and lung metastasectomy at The Cleveland Clinic.(10) From 1986 through 1996, 5787 patients had resection of a colorectal primary cancer and only 72 had PMCC.”
BackgroundStaged pulmonary and hepatic metastasectomy in colorectal cancer—is it worth it?
Reddy, R. (2003) · European Journal of Cardio-Thoracic Surgery · doi:10.1016/j.ejcts.2003.11.020 · Cited by 47
“7 months from the time of last pulmonary resection, which compares favourably with other studies of a similar nature [6–8].”
BackgroundResultSequential surgical resection of hepatic and pulmonary metastases from colorectal cancer
Limmer, S., Oevermann, E., Killaitis, C., Kujath, P., Hoffmann, M., & Bruch, H. (2010) · Langenbeck s Archives of Surgery · doi:10.1007/s00423-010-0595-4 · Cited by 46
“Patients with a solitary metachronous metastases show a benefit in survival [26].”
BackgroundYang, Y. Y. L., Fleshman, J. W., & Strasberg, S. M. (2007) · Journal of Gastrointestinal Surgery · doi:10.1007/s11605-006-0067-x · Cited by 45
“Robinson et al.(67) reported that patients with metachronous resections survived longer than patients with synchronous resections, with median survival of 70 versus 22 months from resection of their primary colorectal cancer.”
BackgroundMethodInfluentialIsolated lung perfusion and related techniques for the treatment of pulmonary metastases☆
Schil, P. E. V., Hendriks, J. M., van Putte, B. P., Stockman, B. A., Lauwers, P., ten Broecke, P. W., Grootenboers, M., & Schramel, F. M. N. H. (2008) · European Journal of Cardio-Thoracic Surgery · doi:10.1016/j.ejcts.2007.12.009 · Cited by 44
Current status of pulmonary metastasectomy from primary epithelial tumors
Yano, T., Shoji, F., & Maehara, Y. (2009) · Surgery Today · doi:10.1007/s00595-008-3820-9 · Cited by 42
Nagakura, S., Shirai, Y., Suda, T., & Hatakeyama, K. (2002) · World Journal of Surgery · doi:10.1007/s00268-001-0196-z · Cited by 42
Bellier, J., Wolf, J. D., Hebbar, M., Amrani, M. E., Desauw, C., Leteurtre, E., Pruvot, F., Porte, H., & Truant, S. (2017) · World Journal of Surgery · doi:10.1007/s00268-017-4265-3 · Cited by 40
Multiple Resections for Hepatic and Pulmonary Metastases of Colorectal Carcinoma
Takahashi, S., Nagai, K., Saito, N., Konishi, M., Nakagohri, T., Gotohda, N., Nishimura, M., Yoshida, J., & Kinoshitá, T. (2007) · Japanese Journal of Clinical Oncology · doi:10.1093/jjco/hym006 · Cited by 36
“Other factors such as synchronous metastasis (5), bilateral or multiple lung metastases (5,7), multiple liver metastases ( 8 ), short disease-free interval (8), simultaneous liver and lung metastases (10), mediastinal nodes involvement (11), primary histology (12) and high levels of both CEA and CA19-9 before metastas…”
BackgroundLong-term outcome after sequential resections of liver and lung metastases from colorectal carcinoma
Marudanayagam, R., Ramkumar, K., Shanmugam, V., Langman, G., Rajesh, P. B., Coldham, C., Bramhall, S. R., Mayer, D. A., Buckels, J. A. C., & Mirza, D. F. (2009) · HPB · doi:10.1111/j.1477-2574.2009.00115.x · Cited by 36
Surgical Treatment of Metastatic Disease to the Lung
Quiros, R. M., & Scott, W. J. (2008) · Seminars in Oncology · doi:10.1053/j.seminoncol.2007.12.010 · Cited by 36
Resection of Colorectal Liver Metastases with Extrahepatic Disease
de Haas, R. J., Wicherts, D. A., & Adam, R. A. (2008) · Digestive Surgery · doi:10.1159/000184737 · Cited by 34
Multidisciplinary management of metastatic colorectal cancer
Yoon, S. S., & Tanabe, K. K. (1998) · Surgical Oncology · doi:10.1016/s0960-7404(99)00022-5 · Cited by 31
SURGICAL TREATMENT FOR PULMONARY METASTASES
Schil, P. E. V. (2002) · Acta Clinica Belgica · doi:10.1179/acb.2002.062 · Cited by 29
Treasure, T., Mineo, T. C., Ambrogi, V., & Fiorentino, F. (2015) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2015.01.067 · Cited by 28
Chirurgie des métastases pulmonaires des cancers colorectaux : facteurs prédictifs de survie
Pagès, P., Pimpec‐Barthes, F. L., & Bernard, A. (2016) · Revue des Maladies Respiratoires · doi:10.1016/j.rmr.2016.02.006 · Cited by 28
“ls montrèrent également que l’apparition des métastases e façon métachrone par rapport au CCR était un facteur de eilleur pronostic que le développement synchrone [24].”
InfluentialDave, R., Pathak, S., White, A. D., Hidalgo, E. L., Prasad, R. K., Lodge, J. P. A., Milton, R. S., & Toogood, G. J. (2014) · British journal of surgery · doi:10.1002/bjs.9737 · Cited by 27
Hepatic metastatic disease in pediatric and adolescent solid tumors
Fernández‐Pineda, I. (2015) · World Journal of Hepatology · doi:10.4254/wjh.v7.i14.1807 · Cited by 27
Labow, D. M., Buell, J. E., Yoshida, A., Rosen, S. A., & Posner, M. C. (2002) · The Cancer Journal · doi:10.1097/00130404-200207000-00011 · Cited by 27
Hepatic metastasectomy in children
Su, W. T., Rutigliano, D. N., Gholizadeh, M., Jarnagin, W. R., Blumgart, L. H., & LaQuaglia, M. P. (2007) · Cancer · doi:10.1002/cncr.22650 · Cited by 26
“nancies included neuroblastoma (7), Wilms tumor (3), osteogenic sarcoma (2),”
BackgroundLocoregional Strategies for Colorectal Hepatic Metastases
Meyers, M. O., Sasson, A. R., & Sigurdson, E. R. (2003) · Clinical Colorectal Cancer · doi:10.3816/ccc.2003.n.010 · Cited by 25
Pulmonary Metastasectomy for Melanoma
OLIARO, A., Filosso, P. L., Bruna, M. C., Mossetti, C., & Ruffini, E. (2010) · Journal of Thoracic Oncology · doi:10.1097/jto.0b013e3181dcf96d · Cited by 25
Colorectal cancer and metastasectomy: The importance of visceral metastasectomy in colorectal cancer
Adam, R. A. (2000) · Annals of Oncology · doi:10.1093/annonc/11.suppl_3.29 · Cited by 25
Surgical treatment of combined hepatic and pulmonary colorectal cancer metastases
Barlow, A. D., Nakas, A., Pattenden, C. J., Martin-Ucar, A. E., Dennison, A. R., Berry, D. P., Lloyd, D., Robertson, G. S., & Waller, D. A. (2008) · European Journal of Surgical Oncology · doi:10.1016/j.ejso.2008.06.012 · Cited by 25
Kim, S., Kim, H. K., Choi, Y. S., Choi, Y. S., Kim, K., Kim, J., Zo, J. I., Shim, Y. M., Heo, J. S., Lee, W. Y., et al. (2016) · World Journal of Surgical Oncology · doi:10.1186/s12957-016-0940-3 · Cited by 24
Zizzo, M., Galeone, C., Braglia, L., Ugoletti, L., Siciliani, A., Nachira, D., Margaritora, S., Pedrazzoli, C., Paci, M., & Lococo, F. (2019) · Digestion · doi:10.1159/000497223 · Cited by 24
Resection of pulmonary metastases from colorectal cancer
Rizk, N. P., & Downey, R. J. (2002) · Seminars in Thoracic and Cardiovascular Surgery · doi:10.1053/stcs.2002.31742 · Cited by 23
The Presence of Colorectal Hepatic Metastases Does Not Preclude Pulmonary Metastasectomy
Patel, N. A., Keenan, R. J., Medich, D., Woo, Y., Celebrezze, J. P., Santucci, T. S., Maley, R. H., Landreneau, R., & Roh, M. S. (2003) · The American Surgeon · doi:10.1177/000313480306901206 · Cited by 23
Surgical resection of synchronous and metachronous lung and liver metastases of colorectal cancers
Jeong, S., Heo, J. S., Park, J. Y., Choi, D. W., & Choi, S. H. (2017) · Annals of Surgical Treatment and Research · doi:10.4174/astr.2017.92.2.82 · Cited by 22
Resection of Hepatic and Pulmonary Metastases in Patients With Colorectal Cancer
Hamy, A., Baron, O., Bennouna, J., Roussel, J., PAINEAU, J., & Douillard, J. (2001) · American Journal of Clinical Oncology · doi:10.1097/00000421-200112000-00016 · Cited by 22
“This suggests that a slower growing malignancy is associated with longer postsurgical survival, which provides some evidence for a relation between growth rate and prognosis.(19) In this study, the serum CEA level before hepatic or pulmonary surgery was always elevated.”
BackgroundFactores pronósticos en metástasis pulmonares resecables de carcinoma colorrectal
Llarena, A. M., Revilla, S. C., Gil-Negrete, A., Ferrer, J. P., Galíndez, R. B., & López-Vivanco, G. (2007) · Archivos de Bronconeumología · doi:10.1157/13106561 · Cited by 21
Ratnayake, B., Wells, C. I., Atherton, P. J., Hammond, J. S., White, S. A., French, J., Manas, D., & Pandanaboyana, S. (2020) · ANZ Journal of Surgery · doi:10.1111/ans.16383 · Cited by 19
“The stage of the primary CRC was reported in five studies.(1,12,21,24,27) Three studies(1,12,27) showed no difference in stage at diagnosis of CRC, in contrast one study Fig 3.”
BackgroundResultInfluentialYamamoto, J., Saiura, A., Koga, R., Seki, M., Ueno, M., Oya, M., Azekura, K., Seto, Y., Ohyama, S., Fukunaga, S., et al. (2004) · International Journal of Clinical Oncology · doi:10.1007/s10147-004-0481-6 · Cited by 17
Prognostic Factors Associated With Resectable Pulmonary Metastases From Colorectal Cancer
Llarena, A. M., Revilla, S. C., Gil-Negrete, A., Ferrer, J. P., Galíndez, R. B., & López-Vivanco, G. (2007) · Archivos de Bronconeumología · doi:10.1016/s1579-2129(07)60076-7 · Cited by 14
Combined liver and lung metastasectomy through an exclusive transthoracic approach
Delis, S., Madariaga, J., Bakoyiannis, A., Avgerinos, C., Touloumis, Z., Vasileios, V., & Dervenis, C. (2007) · Journal of Surgical Oncology · doi:10.1002/jso.20723 · Cited by 14
“Liver and lung are the most common sites of distant metastases [1].”
BackgroundPulmonary metastasis from colorectal carcinoma with hepatic metastasis
Tsukioka, T., Nishiyama, N., Iwata, T., Nagano, K., Izumi, N., Mizuguchi, S., Morita, R., Inoue, K., & Suehiro, S. (2007) · General Thoracic and Cardiovascular Surgery · doi:10.1007/s11748-007-0165-z · Cited by 13
Approach to pulmonary metastases
Yoneda, K. Y., Louie, S., & Shelton, D. K. (2000) · Current Opinion in Pulmonary Medicine · doi:10.1097/00063198-200007000-00018 · Cited by 13
Tratamiento quirúrgico de las metástasis pulmonares: estudio de supervivencia
Navarrete, C. P., Zafra, J. R., Adiego, C. S., de Guevara, A. C. L., Ramos, A. S.-P., & Piña, J. M. D. (2000) · Archivos de Bronconeumología · doi:10.1016/s0300-2896(15)30099-5 · Cited by 13
Sclafani, F., Incarbone, M., Rimassa, L., Personeni, N., Giordano, L., Alloisio, M., & Santoro, A. (2012) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2012.07.097 · Cited by 12
“G T S One of the most intriguing topics is the prognostic significance of a history of hepatic metastases.(7) Few studies specifically addressing this controversial issue have been published.”
BackgroundSugarbaker, P. H. (2013) · Surgical Oncology Clinics of North America · doi:10.1016/j.soc.2012.12.007 · Cited by 12
[Surgical treatment of pulmonary metastasis: survival study].
Navarrete, C. P., Zafra, J. R., Adiego, C. S., Piña, J. M. D., de Guevara, A. C. L., & Ramos, A. S.-P. (2000) · PubMed · Cited by 11
Analysis of treatment that includes both hepatic and pulmonary resections for colorectal metastases
Matsui, T., Kitamura, T., Ozawa, H., Matsuguma, H., & Kotake, K. (2013) · Surgery Today · doi:10.1007/s00595-013-0769-0 · Cited by 10
“Robinson [28] 1999 25 Age, DFI, number of hepatic tumors, simultaneous/sequential”
Transthoracic approach (TTA) for subdiaphragmatic liver metastasectomy.
Delis, S., Bakoyiannis, A., Madariaga, J., Tassopoulos, N., & Dervenis, C. (2008) · PubMed · Cited by 10
Denz, A., Hahn, V., Weber, K., Weber, G. F., Grützmann, R., Krautz, C., & Brunner, M. (2024) · Langenbeck s Archives of Surgery · doi:10.1007/s00423-024-03311-1 · Cited by 9
Current surgical strategies for the treatment of colorectal cancer liver metastases
Adam, R. A. (2004) · European Journal of Cancer Supplements · doi:10.1016/j.ejcsup.2004.04.011 · Cited by 9
Peroperative frozen section analysis of TTF-1 antigen expression
Camilleri‐Broët, S., Alifano, M., Morcos, M., Comperat, E., Magdeleinat, P., Marmey, B., Molina, T. J., Régnard, J. F., & Audouin, J. (2003) · Journal of Clinical Pathology · doi:10.1136/jcp.57.1.98 · Cited by 9
Repeat reduction surgery after an initial hepatectomy for patients with colorectal cancer
Matsuda, K., Hotta, T., Uchiyama, K., Tani, M., Takifuji, K., Yokoyama, S., Higashiguchi, T., Tominaga, T., Oku, Y., Nasu, T., et al. (2007) · Oncology Reports · doi:10.3892/or.18.1.189 · Cited by 8
Migliore, M., Lees, B., Treasure, T., & Fallowfield, L. J. (2013) · The Oncologist · doi:10.1634/theoncologist.2012-0476 · Cited by 7
Imamura, T., Ohgi, K., Mori, K. P., Ashida, R., Yamada, M., Otsuka, S., Uesaka, K., & Sugiura, T. (2023) · Annals of Surgery · doi:10.1097/sla.0000000000006084 · Cited by 7
“54,55 RFS may, therefore, be a more useful surrogate endpoint in PDAC and BTC than nonmetastatic colorectal cancer.”
BackgroundDonington, J. S. (2006) · Springer eBooks · doi:10.1007/0-387-31056-8_93 · Cited by 6
Tanaka, Y., Yamaoka, Y., Shiomi, A., Kagawa, H., Hino, H., Manabe, S., Chen, K., Nanishi, K., & Notsu, A. (2021) · Langenbeck s Archives of Surgery · doi:10.1007/s00423-021-02385-5 · Cited by 5
Multimodality Treatment of Hepatic Metastases
Link, K. H., Apell, V., Holtappels, M., Zayed, K., Sagban, T. A., Mörschel, M., Weigel, T. F., Tischbirek, K., Josten, K. M., Thimm, R., et al. (2005) · Medical radiology · doi:10.1007/3-540-26354-3_26 · Cited by 4
Andersen, P. S., Hornbech, K., Larsen, P. N., Ravn, J. B., & Wettergren, A. (2012) · European surgery. Supplement/European surgery · doi:10.1007/s10353-012-0174-8 · Cited by 4
“[25] 1999 25 47g 43g Headrick et al.”
BackgroundPop, D., Vénissac, N., Leo, F., Karimdjee-Soilihi, B., Lopez, S., & Mouroux, J. (2004) · Annales de Chirurgie · doi:10.1016/j.anchir.2004.09.013 · Cited by 3
“[15] Robinson BJ, Rice TW, Strong SA, Rybicki LA, Blackstone EH.”
The Role of Video-Assisted Thoracic Surgery for Pulmonary Metastasectomy
Lin, J. C.-H., & Landreneau, R. J. (2001) · Clinical Lung Cancer · doi:10.3816/clc.2001.n.012 · Cited by 3
Surgical Management of Colorectal Metastases to the Liver
Cheow, P., & Ooi, L. P. (2003) · Annals of the Academy of Medicine Singapore · doi:10.47102/annals-acadmedsg.v32n2p145 · Cited by 3
Khrizman, P., & Mulcahy, M. F. (2010) · Current Colorectal Cancer Reports · doi:10.1007/s11888-010-0050-5 · Cited by 2
“et al. [ 30 ] 1999 48 NL NL Young age at diagnosis (↑)”
BackgroundInfluentialClinical value of 18F-FDG PET/CT in assessing suspicious relapse after rectal cancer resection
Sun, L. (2009) · World Journal of Gastrointestinal Oncology · doi:10.4251/wjgo.v1.i1.55 · Cited by 2
Current approaches to treating patients with colorectal lung metastases
Ryabov, А. B., Пикин, О. В., Kolbanov, K. I., Глушко, В. А., Вурсол, Д. А., & Александров, О. А. (2018) · P A Herzen Journal of Oncology · doi:10.17116/onkolog2018705152 · Cited by 2
Suzuki, M., Kadoyama, C., Otsuji, M., Sugiura, T., Kimura, F., Suwa, T., & Fujisawa, T. (2000) · Surgery Today · doi:10.1007/s005950070030 · Cited by 2
Rau, B., Kandioler, D., & Stamatis, G. (2009) · Springer eBooks · doi:10.1007/978-3-211-48613-9_13 · Cited by 1
Colorectal Cancer – Management of Metastatic Disease
Sugarbaker, P. H. (2013) · European Oncology & Haematology · doi:10.17925/eoh.2013.09.2.100 · Cited by 1
LUNG METASTATIC DISEASE: SURGICAL RESECTION AND LOCOREGIONAL CHEMOTHERAPY
Hengst, W. A. D., Hendriks, J. M., & Schil, P. E. V. (2012) · Toraks Cerrahisi Bulteni · doi:10.5152/tcb.2012.29 · Cited by 1
Mak, K. L., & Hsin, M. K. Y. (2021) · AME Surgical Journal · doi:10.21037/asj-21-59 · Cited by 1
Donckier, V., Feron, P., Goldman, S., Gansbeke, D. V., Ickx, B., & Gelin, M. (2003) · Cited by 1
RESECTION OF COLORECTAL PULMONARY METASTASES
Rice, T. W. (2005) · Elsevier eBooks · doi:10.1016/b978-1-55664-480-1.50072-1 · Cited by 1
Self-citationLungenmetastasen: Isolierte Lungenperfusion – Klinische Studien
Schil, P. E. V., den Hengst, W., & Hendriks, J. M. (2013) · Springer eBooks · doi:10.1007/978-3-642-35014-6_31
Metastatic Cancers in Lung: Isolated Lung Perfusion – Clinical Studies
Schil, P. E. V., den Hengst, W., & Hendriks, J. M. H. (2011) · Springer eBooks · doi:10.1007/978-3-642-18173-3_26
Cirugía de rescate en el cáncer colorrectal metastásico
álvarez, B. A., Muñoz, M. L., Valls, M. R. A., Rodriguez, J. M. O., Palma, J. P., Jurado, J. C., Hermoso, F. G., & López, N. B. (2000) · Revista de Oncología · doi:10.1007/bf02979567
Follow-up After Potentially Curative Therapy for Rectal Cancer
Nadig, D. E., Virgo, K. S., Longo, W. E., & Johnson, F. E. (2001) · Springer eBooks · doi:10.1007/978-1-4471-0331-8_12
Metadata
- Authors
- Robinson, B. J., Rice, T. W., Strong, S. A., Rybicki, L. A., & Blackstone, E. H.
- Affiliations
- Cleveland Clinic (US)
- Venue
- The Journal of Thoracic and Cardiovascular Surgery
- Publisher
- Elsevier BV
- Published
- 1999-01
- Volume
- 117
- Issue
- 1
- Pages
- 66-76
- ISSN
- 0022-5223 (ISSN-L)
- OpenAlex
- W2069317815
- Cited by
- 111
- References
- 17
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 2 · 2021: 2 · 2020: 1 · 2019: 2 · 2018: 1 · 2017: 3 · 2016: 4 · 2015: 4 · 2014: 3 · 2013: 6 · 2012: 5
- FWCI
- 3.38
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Thoracic and Cardiovascular Surgery (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Colorectal Cancer Treatments and Studies
- Health Sciences › Medicine › Oncology › Colorectal Cancer Surgical Treatments
- Health Sciences › Medicine › Surgery › Intraperitoneal and Appendiceal Malignancies
- Keywords
- colorectal cancer, metastasectomy, liver metastasis, lung metastasis, metachronous metastasis, synchronous metastases, survival, disease-free interval, mortality risk factors, solitary liver metastasis
- MeSH terms
- Female, Humans, Liver Neoplasms, Lung Neoplasms, Male, Neoplasm Staging, Risk Factors, Colorectal Neoplasms, Multivariate Analysis, Survival Analysis, Treatment Outcome, Patient Selection
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