The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Is resection of pulmonary and hepatic metastases warranted in patients with colorectal cancer?
Open accessAbstract
Background Conventional management of stage IV colorectal carcinoma is palliative. The value of resecting both liver and lung colorectal metastases that occur in isolation of other sites of metastasis is undetermined.Objectives Our objectives were to (1) assess the efficacy of resecting both hepatic and pulmonary metastases, (2) investigate the influence of the sequence and timing of metastases, and (3) identify the profile of patients likely to benefit from both hepatic and pulmonary metastasectomy.Patients and methods Of 48 patients identified with resection of colorectal cancer and, at some point in time, both liver and lung metastases, 25 patients underwent metastasectomy (resection group). The remaining 23 patients comprised the nonresection group. Risk factors for death were identified by multivariable analyses.Results Median survival was longer after the last metastatic appearance in the resection group (16 months) than in the nonresection group (6 months; P <.001). The pattern of risk also differed; it peaked at 2 years and then declined in the resection group but was constant in the nonresection group. In the resection group, patients with metachronous resections survived longer after colorectal resection (median, 70 months) than patients with synchronous (median, 22 months) or mixed resections (median, 31 months; P <.001). Risk factors for death included older age, multiple liver metastases, and a short disease-free interval.Conclusions Younger patients with solitary metachronous metastases to the liver, then the lung, and long disease-free intervals are more likely to benefit from resection of both liver and lung metastases. Patients with risk factors also had better survival with resection than without resection.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“There are reports showing the efficacy of hepatectomy in patients who have controllable extrahepatic metastases (mainly lung metastases) in addition to liver metastases [35, 36, 39, 43] (CQ-7).”
From Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines 2016 for the treatment of colorectal cancer (2018) · cites this paper as [39]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Nonparametric Estimation from Incomplete Observations
Kaplan, E. L., & Meier, P. (1992) · Springer series in statistics · doi:10.1007/978-1-4612-4380-9_25 · Cited by 45,239
Regression Models and Life-Tables
Cox, D. R. (1972) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1972.tb00899.x · Cited by 39,793
Nonparametric Estimation from Incomplete Observations
Kaplan, E. L., & Meier, P. (1958) · Journal of the American Statistical Association · doi:10.1080/01621459.1958.10501452 · Cited by 39,158
Regression Models and Life-Tables
Cox, D. R. (1992) · Springer Series in Statistics · doi:10.1007/978-1-4612-4380-9_37 · Cited by 26,297
Blackstone, E. H., Naftel, D. C., & Turner, M. E. (1986) · Journal of the American Statistical Association · doi:10.1080/01621459.1986.10478314 · Cited by 646
Self-citationBootstrap investigation of the stability of a cox regression model
Altman, D. G., & Andersen, P. K. (1989) · Statistics in Medicine · doi:10.1002/sim.4780080702 · Cited by 311
Surgery for lung metastases from colorectal cancer: analysis of prognostic factors.
Girard, P., Ducreux, M. P., Baldeyrou, P., Rougier, P. R., Chevalier, T. L., Bougaran, J., Lasser, P., Gayet, B., Ruffiè, P., & Grunenwald, D. H. (1996) · Journal of Clinical Oncology · doi:10.1200/jco.1996.14.7.2047 · Cited by 185
Long-term effects of testicular cancer on sexual functioning in married couples
Gritz, E. R., Wellisch, D. K., Wang, H.-J., Siau, J., Landsverk, J. A., & Cosgrove, M. D. (1989) · Cancer · doi:10.1002/1097-0142(19891001)64:7 · Cited by 86
Repeat hepatic resections for colorectal metastases.
Griffith, K. D., Sugarbaker, P. H., & Chang, A. E. (1990) · PubMed · Cited by 86
Results of pulmonary resection of metastatic colorectal cancer and its application
Yano, T., Hara, N., Ichinose, Y., Yokoyama, H., Miura, T., & Ohta, M. (1993) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/s0022-5223(19)34042-5 · Cited by 80
Research works printed but not linked: 1
- Äberg, 1997, Selection mechanisms as major determinants of survival after pulmonary metastasectomy, Ann Thorac Surg, 63, 611
Cited by
Sorted by citations
Items 101–111 of 111
Medina-Fernández, F. J., Jiménez, D. E., Luque-Molina, A., López‐Cillero, P., & Peña, S. R. (2014) · Cirugía Española (English Edition) · doi:10.1016/j.cireng.2012.05.006
Resection of pulmonary metastases after hepatic metastases from colorectal cancer.
Tanaka, R., Amemiya, R., Asato, Y., Kiyoshima, M., Oka, D., Ikeda, M., & Yoshimi, F. (2001) · The Journal of the Japanese Association for Chest Surgery · doi:10.2995/jacsurg.15.92
Sumpter, K., & Cunningham, D. (2001) · Springer eBooks · doi:10.1007/978-1-4471-0331-8_14
Medina-Fernández, F. J., Jiménez, D. E., Luque-Molina, A., López‐Cillero, P., & Peña, S. R. (2012) · Cirugía Española · doi:10.1016/j.ciresp.2012.05.022
Resection of Colorectal Metastases to the Lung
Downey, R. J. (2002) · Humana Press eBooks · doi:10.1007/978-1-59259-160-2_21
Hiroo, K. U. N. O., Tanimura, H., YAMAMOTO, M., Tani, M., & Yamaue, H. (2001) · Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association) · doi:10.3919/jjsa.62.977
Metastatic Cancers in Lung: Isolated Lung Perfusion: Clinical Studies
Schil, P. E. V., den Hengst, W., & Hendriks, J. M. H. (2016) · Springer eBooks · doi:10.1007/978-3-319-28773-7_31
Rehabilitation and palliation of patients with colon cancer
(2008) · Collection de l'Académie européenne de médecine de réadaptation · doi:10.1007/978-2-287-72827-3_10
Sugenoya, S., Nakata, T., NAKAMURA, K., Watanabe, T., OKITA, K., Kasuga, Y., & UEHARA, G. (2023) · Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association) · doi:10.3919/jjsa.84.773
Impact of surgery for colorectal cancer liver metastasis: Systematic review and meta-analysis
Petrelli, F., Cherri, S., Ghidini, A., Rossitto, M., Bukovec, R., Roncari, L., Dottorini, L., Arru, M., Libertini, M., & Zaniboni, A. (2026) · World Journal of Clinical Oncology · doi:10.5306/wjco.v17.i5.118670
Metadata
- Authors
- Robinson, B. J., Rice, T. W., Strong, S. A., Rybicki, L. A., & Blackstone, E. H.
- Affiliations
- Cleveland Clinic (US)
- Venue
- The Journal of Thoracic and Cardiovascular Surgery
- Publisher
- Elsevier BV
- Published
- 1999-01
- Volume
- 117
- Issue
- 1
- Pages
- 66-76
- ISSN
- 0022-5223 (ISSN-L)
- OpenAlex
- W2069317815
- Cited by
- 111
- References
- 17
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 2 · 2021: 2 · 2020: 1 · 2019: 2 · 2018: 1 · 2017: 3 · 2016: 4 · 2015: 4 · 2014: 3 · 2013: 6 · 2012: 5
- FWCI
- 3.38
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Thoracic and Cardiovascular Surgery (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Colorectal Cancer Treatments and Studies
- Health Sciences › Medicine › Oncology › Colorectal Cancer Surgical Treatments
- Health Sciences › Medicine › Surgery › Intraperitoneal and Appendiceal Malignancies
- Keywords
- colorectal cancer, metastasectomy, liver metastasis, lung metastasis, metachronous metastasis, synchronous metastases, survival, disease-free interval, mortality risk factors, solitary liver metastasis
- MeSH terms
- Female, Humans, Liver Neoplasms, Lung Neoplasms, Male, Neoplasm Staging, Risk Factors, Colorectal Neoplasms, Multivariate Analysis, Survival Analysis, Treatment Outcome, Patient Selection
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
