Cited by 566Adipokines, Inflammation, and Metabolic DiseasesCytokine Signaling Pathways and InteractionsSkin Diseases and Diabetes

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Plasma interleukin-6, tumour necrosis factor α and blood cytokine production in type 2 diabetes

Pickup, John C., Chusney, Gary D., Thomas, Stephen M., Burt, Davina·2000·Life Sciences

DOI 10.1016/s0024-3205(00)00622-6

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Abstract

Type 2 diabetes is associated with increased circulating concentrations of markers of the acute-phase response and interleukin-6 (IL-6). An augmented acute-phase response may be a mechanism which explains many of the clinical and biochemical features of type 2 diabetes and its complications. We sought to confirm that circulating concentrations of the cytokine acute-phase mediators IL-6 and tumour necrosis factor alpha [TNFalpha] are elevated in type 2 diabetes, and investigated blood as a source of cytokines in type 2 diabetes. Blood samples from 20 type 2 diabetic and 17 age-matched healthy subjects were incubated in vitro for 24 hr with and without lipopolysaccharide (LPS) stimulation and secreted cytokines measured. Plasma IL-6 and TNFalpha were significantly increased in type 2 diabetes compared to normal subjects. However, basal production of IL-6 and TNFalpha in cultured diabetic blood was markedly depressed in comparison with non-diabetic samples. IL-6 and TNFalpha production was increased in blood in response to LPS, reaching similar levels in diabetic and non-diabetic subjects, though IL-6 was slightly but significantly higher in controls. We conclude that circulating levels of IL-6 and TNFalpha are increased in type 2 diabetes but there is downregulation of basal cytokine production in blood cells in type 2 diabetes. Blood has the capacity to produce cytokines in diabetes which contribute to the augmented acute-phase response, but the main source of the increased plasma IL-6 and TNFalpha concentrations may be from non-circulating cells.

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Authors: Pickup, J. C., Chusney, G. D., Thomas, S. M., & Burt, D.
Affiliations: Guy's Hospital (GB)
Corresponding author: Pickup, John C.
Venue: Life Sciences
Publisher: Elsevier BV
Published: 2000-06
Volume: 67
Issue: 3
Pages: 291-300
ISSN: 0024-3205 (ISSN-L)
DOI: 10.1016/s0024-3205(00)00622-6
OpenAlex: W2084483597
Cited by: 566
References: 0
Citations by year: 2026: 4 · 2025: 19 · 2024: 18 · 2023: 21 · 2022: 13 · 2021: 23 · 2020: 26 · 2019: 20 · 2018: 20 · 2017: 17 · 2016: 24 · 2015: 25 · 2014: 35 · 2013: 29 · 2012: 21
FWCI: 11.17
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Life Sciences (publishedVersion)
PubMed (publishedVersion)
Research Portal (King's College London) (submittedVersion)
Funders: Bupa Foundation
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
Health Sciences › Medicine › Dermatology › Skin Diseases and Diabetes
Keywords: type 2 diabetes, interleukin-6, TNF-α, acute phase response, lipopolysaccharide stimulation, plasma cytokines, cytokine downregulation, inflammation in diabetes
MeSH terms: Acute-Phase Reaction, Diabetes Mellitus, Type 2, Female, Humans, Immunoenzyme Techniques, Lipopolysaccharides, Male, Middle Aged, Tumor Necrosis Factor-alpha, Interleukin-6, N-Acetylneuraminic Acid

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Plasma interleukin-6, tumour necrosis factor α and blood cytokine production in type 2 diabetes

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