Cited by 566Adipokines, Inflammation, and Metabolic DiseasesCytokine Signaling Pathways and InteractionsSkin Diseases and Diabetes

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Plasma interleukin-6, tumour necrosis factor α and blood cytokine production in type 2 diabetes

Pickup, John C., Chusney, Gary D., Thomas, Stephen M., Burt, Davina·2000·Life Sciences

DOI 10.1016/s0024-3205(00)00622-6

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Abstract

Type 2 diabetes is associated with increased circulating concentrations of markers of the acute-phase response and interleukin-6 (IL-6). An augmented acute-phase response may be a mechanism which explains many of the clinical and biochemical features of type 2 diabetes and its complications. We sought to confirm that circulating concentrations of the cytokine acute-phase mediators IL-6 and tumour necrosis factor alpha [TNFalpha] are elevated in type 2 diabetes, and investigated blood as a source of cytokines in type 2 diabetes. Blood samples from 20 type 2 diabetic and 17 age-matched healthy subjects were incubated in vitro for 24 hr with and without lipopolysaccharide (LPS) stimulation and secreted cytokines measured. Plasma IL-6 and TNFalpha were significantly increased in type 2 diabetes compared to normal subjects. However, basal production of IL-6 and TNFalpha in cultured diabetic blood was markedly depressed in comparison with non-diabetic samples. IL-6 and TNFalpha production was increased in blood in response to LPS, reaching similar levels in diabetic and non-diabetic subjects, though IL-6 was slightly but significantly higher in controls. We conclude that circulating levels of IL-6 and TNFalpha are increased in type 2 diabetes but there is downregulation of basal cytokine production in blood cells in type 2 diabetes. Blood has the capacity to produce cytokines in diabetes which contribute to the augmented acute-phase response, but the main source of the increased plasma IL-6 and TNFalpha concentrations may be from non-circulating cells.

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Tuttle, H. A., Davis‐Gorman, G., Goldman, S., Copeland, J. G., & McDonagh, P. F. (2004) · Journal of Diabetes and its Complications · doi:10.1016/s1056-8727(03)00088-6 · Cited by 73
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Román-Ramos, R., Almanza-Pérez, J., García-Macedo, R., Blancas-Flores, G., Fortis-Barrera, Á., Jasso, E. I., García-Lorenzana, M., Campos-Sepúlveda, A. E., Cruz, M., & Alarcón-Aguilar, F. (2011) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/j.1742-7843.2011.00671.x · Cited by 76
The 2012 SEMDSA Guideline for the Management of Type 2 Diabetes
Amod, A. (2012) · Journal of Endocrinology Metabolism and Diabetes of South Africa · doi:10.1080/22201009.2012.10872276 · Cited by 69
“Eur J Clin Invest 2004; 34(8): 535-542 21.”
Anti‐inflammatory effects of exendin‐4, a glucagon‐like peptide‐1 analog, on human peripheral lymphocytes in patients with type 2 diabetes
He, L., Wong, C. K., Cheung, K. K., Yau, H. C., Fu, A., Zhao, H., Leung, K. M., Kong, A. P., Wong, G. W., Chan, P. K., et al. (2013) · Journal of Diabetes Investigation · doi:10.1111/jdi.12063 · Cited by 70
Preventive effects of bitter melon (Momordica charantia) against insulin resistance and diabetes are associated with the inhibition of NF-κB and JNK pathways in high-fat-fed OLETF rats
Yang, S. J., Choi, J. M., Park, S. E., Rhee, E., Lee, W., Oh, K. W., Park, S. W., & Park, C. (2014) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2014.10.010 · Cited by 69
Effects ofSambucus nigraandAronia melanocarpaextracts on immune system disorders within diabetes mellitus
Bădescu, M., Bădulescu, O. V., Bădescu, L., & Ciocoiu, M. (2014) · Pharmaceutical Biology · doi:10.3109/13880209.2014.931441 · Cited by 69
“These interleukins, especially IL-1 and IL-6, contribute greatly to inflammation intensification (Heinrich et al., 1990; Pickup et al., 2000).”
Background
Factors accounting for high ferritin levels in obesity
Lecube, A., Hernández, C., Pelegrí, D., & Simó, R. (2008) · International Journal of Obesity · doi:10.1038/ijo.2008.154 · Cited by 68
Cellular inflammatory responses: Novel insights for obesity and insulin resistance
Chen, H. (2006) · Pharmacological Research · doi:10.1016/j.phrs.2006.03.003 · Cited by 68
Inflammatory biomarkers in type 2 diabetic patients: effect of glycemic control and impact of ldl subfraction phenotype
Vinagre, I., Sánchez‐Quesada, J. L., Sánchez-Hernández, J. J., Santos, D., Ordóñez‐Llanos, J., de Leiva, A., & Pérez, A. (2014) · Cardiovascular Diabetology · doi:10.1186/1475-2840-13-34 · Cited by 67
Pentoxifylline for Renal Protection in Diabetic Kidney Disease. A Model of Old Drugs for New Horizons
Donate‐Correa, J., Tagua, V. G., Ferri, C. M., Martín‐Núñez, E., Hernández-Carballo, C., Ureña, P., Ruiz‐Ortega, M., Ortíz, A., Fernández, C. M., & Navarro‐González, J. F. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8030287 · Cited by 66
“Plasma concentrations of inflammatory molecules, including proinflammatory cytokines, are elevated in patients with DM [19,20].”
Background
Current Status of Angiogenic Cell Therapy and Related Strategies Applied in Critical Limb Ischemia
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Diabetes-Induced Activation of Canonical and Noncanonical Nuclear Factor-κB Pathways in Renal Cortex
Starkey, J. M., Haidacher, S. J., LeJeune, W. S., Zhang, X., Tieu, B. C., Choudhary, S., Brasier, A. R., Denner, L. A., & Tilton, R. G. (2006) · Diabetes · doi:10.2337/db05-1554 · Cited by 65
“The proinflammatory cytokines interleukin (IL)-6, tumor necrosis factor (TNF)- , and IL-1 , as well as plasminogen activator inhibitor are increased in diabetic patients and are independently correlated with duration of diabetes (11,12), suggesting that chronic hyperglycemia creates a proinflammatory milieu.”
Background
Nephropathic complication of type-2 diabetes is following pattern of autoimmune diseases?
Arababadi, M. K., Nosratabadi, R., Hassanshahi, G., Yaghini, N., Pooladvand, V., Shamsizadeh, A., Hakimi, H., & Derakhshan, R. (2009) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2009.09.027 · Cited by 64
Serum concentrations of cortisol, interleukin 6, leptin and adiponectin predict stress induced insulin resistance in acute inflammatory reactions
Lehrke, M., Broedl, U. C., Biller-Friedmann, I. M., Vogeser, M., Henschel, V., Nassau, K., Göke, B., Kilger, E., & Parhofer, K. G. (2008) · Critical Care · doi:10.1186/cc7152 · Cited by 64
“Initial evidence for a functional interplay was created by increased serum levels of IL6 in obesity in which IL6 was found to be associated with insulin resistance [ 14-17 ].”
Background
Beneficial effects of flaxseed oil and fish oil diet are through modulation of different hepatic genes involved in lipid metabolism in streptozotocin–nicotinamide induced diabetic rats
Devarshi, P. P., Jangale, N. M., Ghule, A. E., Bodhankar, S. L., & Harsulkar, A. (2012) · Genes & Nutrition · doi:10.1007/s12263-012-0326-2 · Cited by 62
“T2DM patients have higher circulating levels of these cytokines, probably produced by non-circulating cells such as hepatocytes (Pickup et al. 2000).”
Background
Cytokine profiling of young overweight and obese female African American adults with prediabetes
Lucas, R., Parikh, S. J., Sridhar, S., Guo, D.-H., Bhagatwala, J., Dong, Y., Caldwell, R. B., Mellor, A. L., Caldwell, W., Zhu, H., et al. (2013) · Cytokine · doi:10.1016/j.cyto.2013.05.025 · Cited by 61
“T2D is now recognized as an immune-mediated disease leading to impaired insulin signaling and selective destruction of insulin producing b-cells, in which cytokines play an important role [13,28,29].”
Caloric restriction inhibits up-regulation of inflammatory cytokines and TNF-α, and activates IL-10 and haptoglobin in the plasma of streptozotocin-induced diabetic rats
Ugochukwu, N. H., & Figgers, C. L. (2006) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2006.03.008 · Cited by 61
Vascular endothelium and inflammatory process, in patients with combined Type 2 diabetes mellitus and coronary atherosclerosis: the effects of vitamin C
Antoniades, C. A., Tousoulis, D., Tountas, C. D., Tentolouris, C., Toutouza, M., Vasiliadou, C., Tsioufis, C. P., TOUTOUZAS, P. K., & Stefanadis, C. (2004) · Diabetic Medicine · doi:10.1111/j.1464-5491.2004.01201.x · Cited by 60
Effects of rosiglitazone and aspirin on experimental model of induced type 2 diabetes in rats: focus on insulin resistance and inflammatory markers
Abdin, A. A., Baalash, A., & Hamooda, H. E. (2009) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2009.01.005 · Cited by 62
The Mechanism of Contrast-Induced Acute Kidney Injury and Its Association with Diabetes Mellitus
Li, Y., & Ren, K. (2020) · Contrast Media & Molecular Imaging · doi:10.1155/2020/3295176 · Cited by 65
Circulating pro-inflammatory cytokines and adiponectin in young men with type 2 diabetes
Su, S., Pei, D., Hsieh, C., Hsiao, F., Wu, C., & Hung, Y.-J. (2010) · Acta Diabetologica · doi:10.1007/s00592-009-0171-y · Cited by 59
“Moreover, several reports in the literature have evidenced that the properties of inflammation and atherogenesis coexisted in several populations, including adult-onset diabetes, obesity and metabolic syndrome [10, 14, 16, 20, 21].”
BMP-7 attenuates adverse cardiac remodeling mediated through M2 macrophages in prediabetic cardiomyopathy
Urbina, P., & Singla, D. K. (2014) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00367.2014 · Cited by 60
“Several clinical studies (2, 22, 24) have shown increased levels of monocytes and proinflammatory cytokines, TNF- and IL-6, in PD patients.”
BackgroundResult
Role of adipocytokines in predicting the development of diabetes and its late complications
Gülçelik, N. E., Usman, A., & Gürlek, A. (2009) · Endocrine · doi:10.1007/s12020-009-9234-7 · Cited by 60
Glycaemic status in relation to oxidative stress and inflammation in well-controlled type 2 diabetes subjects
Rytter, E., Vessby, B. O., Åsgård, R., et al. (2009) · British Journal Of Nutrition · doi:10.1017/s0007114508076204 · Cited by 59
The 2012 SEMDSA Guideline for the Management of Type 2 Diabetes (Revised)
(2012) · Journal of Endocrinology Metabolism and Diabetes of South Africa · doi:10.1080/22201009.2012.10872287 · Cited by 58
“Eur J Clin Invest 2004; 34(8): 535-542 21.”
Correlation between Insulin Resistance and Thyroid Nodule in Type 2 Diabetes Mellitus
Tang, Y., Yan, T., Gang, W., Chen, Y., Zhu, Y., Jiang, Z., Yang, M. H., Li, C., Li, Z., Yü, P., et al. (2017) · International Journal of Endocrinology · doi:10.1155/2017/1617458 · Cited by 59
“In van der Poll’s study, TNF induced decreases in T3 and TSH levels, either directly or indirectly, in the pathogenesis of the ESS [33].”
Background

Authors: Pickup, J. C., Chusney, G. D., Thomas, S. M., & Burt, D.
Affiliations: Guy's Hospital (GB)
Corresponding author: Pickup, John C.
Venue: Life Sciences
Publisher: Elsevier BV
Published: 2000-06
Volume: 67
Issue: 3
Pages: 291-300
ISSN: 0024-3205 (ISSN-L)
DOI: 10.1016/s0024-3205(00)00622-6
OpenAlex: W2084483597
Cited by: 566
References: 0
Citations by year: 2026: 4 · 2025: 19 · 2024: 18 · 2023: 21 · 2022: 13 · 2021: 23 · 2020: 26 · 2019: 20 · 2018: 20 · 2017: 17 · 2016: 24 · 2015: 25 · 2014: 35 · 2013: 29 · 2012: 21
FWCI: 11.17
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Life Sciences (publishedVersion)
PubMed (publishedVersion)
Research Portal (King's College London) (submittedVersion)
Funders: Bupa Foundation
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
Health Sciences › Medicine › Dermatology › Skin Diseases and Diabetes
Keywords: type 2 diabetes, interleukin-6, TNF-α, acute phase response, lipopolysaccharide stimulation, plasma cytokines, cytokine downregulation, inflammation in diabetes
MeSH terms: Acute-Phase Reaction, Diabetes Mellitus, Type 2, Female, Humans, Immunoenzyme Techniques, Lipopolysaccharides, Male, Middle Aged, Tumor Necrosis Factor-alpha, Interleukin-6, N-Acetylneuraminic Acid

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Plasma interleukin-6, tumour necrosis factor α and blood cytokine production in type 2 diabetes

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