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Transsphenoidal Removal of Pituitary Microadenoma in Cushing’s Disease
Open accessAbstract
Twenty-two of 32 patients with Cushing's disease seen at the Mayo Clinic during a 3-year period were carefully studied radiologically (triaxial spiral tomograms of the sella and bilateral carotid arteriograms with magnification and subtraction techniques). Eighteen of these 22 pat-ents had radiologic evidence of small pituitary gland tumors and underwent transsphenoidal microsurgical exploration of the pituitary. A microadenoma (less than 10 mm) was found in 17 of the 18 patients. Hypercortisolism was corrected, and a clinical remission occurred in 16 of the 18 patients; the hypercortisolism persisted in 2 patients. A period of hypocortisolism occurred after removal of the pituitary tumor in all patients who experienced a remission. Remissions have been associated with normal anterior pituitary and adrenocortical function in a large percentage of patients who were adequately studied 6 months or more after pituitary surgery.
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Citations
Cited by
The Treatment of Cushing's Disease
Pivonello, R., De Leo, M., Cozzolino, A., & Colao, A. (2015) · Endocrine Reviews · doi:10.1210/er.2013-1048 · Cited by 465
Cushing's syndrome: a review of diagnostic tests.
Crapo, L. (1979) · Metabolism · doi:10.1016/0026-0495(79)90097-0 · Cited by 393
Long-term results in transsphenoidal removal of nonfunctioning pituitary adenomas
Ebersold, M. J., Quast, L. M., Laws, E. R., Scheithauer, B., & Randall, R. V. (1986) · Journal of Neurosurgery · doi:10.3171/jns.1986.64.5.0713 · Cited by 324
Self-citationLate Recurrences of Cushing’s Disease after Initial Successful Transsphenoidal Surgery
Patil, C. G., Prevedello, D. M., Lad, S. P., Vance, M. L., Thorner, M. O., Katznelson, L., & Laws, E. R. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-2013 · Cited by 320
Self-citationRees, D. A., Hanna, F. W. F., Davies, J. S., Mills, R. G., Vafidis, J., & Scanlon, M. F. (2002) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2002.01511.x · Cited by 261
Metadata
- Authors
- Salassa, R. M., Laws, E. R., Carpenter, P. C., & Northcutt, R. C.
- Venue
- Mayo Clinic Proceedings
- Publisher
- Elsevier BV
- Published
- 1978-01
- Volume
- 53
- Issue
- 1
- Pages
- 24-28
- ISSN
- 0025-6196 (ISSN-L)
- OpenAlex
- W7124728998
- Cited by
- 204
- References
- 0
- FWCI
- 14.85
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Transsphenoidal Removal of Pituitary Microadenoma in Cushing’s Disease. https://app.cochat.ai/papers/10.1016/s0025-6196(25)38014-6
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- Salassa, R. M., Laws, E. R., Carpenter, P. C., & Northcutt, R. C. (1978). Transsphenoidal Removal of Pituitary Microadenoma in Cushing’s Disease. Mayo Clinic Proceedings. https://doi.org/10.1016/s0025-6196(25)38014-6
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
