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The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.

Late Recurrences of Cushing’s Disease after Initial Successful Transsphenoidal Surgery

Open access
Patil, Chirag G., Prevedello, Daniel M., Lad, Shivanand P., Vance, Mary Lee, Thorner, Michael O., Katznelson, Laurence, Laws, Edward R.·2008·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jc.2007-2013
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Abstract

Context: Few studies have systematically analyzed the long-term recurrence rates of Cushing’s disease after initial successful transsphenoidal surgery. Setting: This was a retrospective review of patients treated at the University of Virginia Medical Center. Patients: A total of 215 subjects with Cushing’s disease who underwent initial transsphenoidal surgery for resection of a presumed pituitary microadenoma from 1992–2006 were included. Main Outcome Measures: Remission and recurrence rates of Cushing’s disease were examined. Recurrence was defined as an elevated 24-h urine free cortisol with clinical symptoms consistent with Cushing’s disease. Results: Of the 215 patients who underwent transsphenoidal surgery for Cushing’s disease, surgical remission was achieved in 184 (85.6%). The mean length of follow-up was 45 months. Actuarial recurrence rates of Cushing’s disease after initially successful transsphenoidal surgery at 1, 2, 3, and 5 yr were 0.5, 6.7, 10.8, and 25.5%, respectively. Among the 184 patients who achieved remission, 32 (17.4%) patients followed for more than 6 months ultimately had a recurrence of Cushing’s disease. The median time to recurrence was 39 months. Immediate postoperative hypocortisolemia (serum cortisol ≤ 2 μg/dl within 72-h surgery) was achieved in 97 (45.1%) patients. Patients who had postoperative serum cortisol of more than 2 μg/dl were 2.5 times more likely to have a recurrence than patients who had serum cortisol less than or equal to 2 μg/dl (odds ratio = 2.5; 95% confidence interval 1.12–5.52; P = 0.022). Conclusions: A quarter of the patients with Cushing’s disease who achieve surgical remission after transsphenoidal surgery, recur with long-term follow-up. This finding emphasizes the need for continued biochemical and clinical follow-up to ensure remission after surgery.

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Metadata

Authors
Patil, C. G., Prevedello, D. M., Lad, S. P., Vance, M. L., Thorner, M. O., Katznelson, L., & Laws, E. R.
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
2008-02-01
Volume
93
Issue
2
Pages
358-362
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jc.2007-2013
OpenAlex
W2093010614
Cited by
320
References
34
FWCI
9.82
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Late Recurrences of Cushing’s Disease after Initial Successful Transsphenoidal Surgery. https://app.cochat.ai/papers/10.1210/jc.2007-2013
The paper
Patil, C. G., Prevedello, D. M., Lad, S. P., Vance, M. L., Thorner, M. O., Katznelson, L., & Laws, E. R. (2008). Late Recurrences of Cushing’s Disease after Initial Successful Transsphenoidal Surgery. The Journal of Clinical Endocrinology & Metabolism. https://doi.org/10.1210/jc.2007-2013

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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