The DOI matches its Crossref record; 11 of the 12 references it cites were found in a registry or an index.
Identification of a Novel Dioxin-Inducible Cytochrome P450
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In the citing paper
“This receptor was also more highly expressed in Hepa1–6, providing a ready explanation for the up-regulation.”
From Comparative proteomic phenotyping of cell lines and primary cells to assess preservation of cell type-specific functions (2009) · cites this paper as [26]
In the citing paper
“Two of them (CYP1A1 and CYP2S1) are known to be regulated by the aryl hydrogen receptor (25, 26).”
From Comparative proteomic phenotyping of cell lines and primary cells to assess preservation of cell type-specific functions (2009) · cites this paper as [26]
Citations
Cites
The Aryl Hydrocarbon Receptor Complex
Hankinson, O. (1995) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.35.040195.001515 · Cited by 1,649 · cited 1×
“Dioxin is the most carcinogenic substance evaluated (Hankinson, 1995).”
Self-citationINDUCTION OF CYTOCHROME P4501A1
Whitlock, J. P. (1999) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.39.1.103 · Cited by 1,136
Savas, Ü., Bhattacharyya, K. K., Christou, M., Alexander, D. L., & Jefcoate, C. R. E. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)36551-1 · Cited by 206
Induction of mRNA specific for cytochrome P1-450 in wild type and variant mouse hepatoma cells.
Israel, D. I., & Whitlock, J. P. (1983) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)44469-3 · Cited by 115
Dey, A., Jones, J. E., & Nebert, D. W. (1999) · Biochemical Pharmacology · doi:10.1016/s0006-2952(99)00110-0 · Cited by 113
Identification and Tissue Distribution of the Novel Human Cytochrome P450 2S1 (CYP2S1)
Rylander‐Rudqvist, T., Neve, E. P. A., Ingelman‐Sundberg, M., & Oscarson, M. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.4390 · Cited by 106
Israel, D. I., Estolano, M. G., Galeazzi, D. R., & Whitlock, J. P. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)89072-x · Cited by 103
Sun, W., Zhang, J., & Hankinson, O. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.50.31845 · Cited by 63
Self-citationSantostefano, M. J., Ross, D. G., Savas, Ü., Jefcoate, C. R. E., & Birnbaum, L. S. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.6389 · Cited by 56
A genetic analysis of processes regulating cytochrome P4501A1 expression
Hankinson, O. (1994) · Advances in Enzyme Regulation · doi:10.1016/0065-2571(94)90015-9 · Cited by 24
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Elshenawy, O. H., & El‐Kadi, A. O. S. (2015) · Xenobiotica · doi:10.3109/00498254.2015.1032385 · Cited by 14
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Alqahtani, M. A., El‐Ghiaty, M. A., & El‐Kadi, A. O. S. (2022) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.23243 · Cited by 13
Arsenic Through the Gastrointestinal Tract
Calatayud, M., & Llopis, J. M. L. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-418688-0.00010-1 · Cited by 15
Functional Genomics Approaches to Studies of the Cytochrome P450 Superfamily
Režen, T., Contreras, J. A., & Rozman, D. (2007) · Drug Metabolism Reviews · doi:10.1080/03602530701498760 · Cited by 13
Drug Metabolism: Significance and Challenges
Prakash, C., & Vaz, A. D. N. (2008) · Wiley eBooks · doi:10.1002/9780470409107.ch1 · Cited by 13
Knockdown CYP2S1 inhibits lung cancer cells proliferation and migration
Guo, H., Zeng, B., Wang, L., Ge, C., Zuo, X., Li, Y., Ding, W., Deng, L., Zhang, J., Qian, X., et al. (2021) · Cancer Biomarkers · doi:10.3233/cbm-210189 · Cited by 12
Madanayake, T. W., Lindquist, I. E., Devitt, N. P., Mudge, J., & Rowland, A. M. (2013) · BMC Genomics · doi:10.1186/1471-2164-14-833 · Cited by 12
CYP2S1 is negatively regulated by corticosteroids in human cell lines
Bebenek, I. G., Solaimani, P., Bui, P. H., & Hankinson, O. (2011) · Toxicology Letters · doi:10.1016/j.toxlet.2011.11.020 · Cited by 12
Self-citationFlavonoids and Resveratrol as Regulators of Ah-Receptor Activity: Protection from Dioxin Toxicity
Tutelyan, V. A., Gapparov, M. M. G., Telegin, L. Y., Vm, D., & Pevnitskiĭ, L. A. (2003) · Bulletin of Experimental Biology and Medicine · doi:10.1023/b:bebm.0000020196.18460.99 · Cited by 12
Metabolism of Xenobiotics in the Respiratory Tract
Tran, L. M., Zhang, Q.-Y., Winkle, L. S. V., & Ding, X. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-95488-4.00101-7 · Cited by 12
Biochemical Function of the Respiratory Tract: Metabolism of Xenobiotics
Ding, X., Li, L., Winkle, L. S. V., & Zhang, Q.-Y. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.95653-8 · Cited by 11
CYP2S1 Gene Polymorphisms in a Korean Population
Jang, Y., Cha, E., Kim, W., Park, S. W., Shon, J., Lee, S. S., & Shin, J. (2007) · Therapeutic Drug Monitoring · doi:10.1097/ftd.0b013e318058a4e0 · Cited by 8
Brauze, D. (2004) · Toxicology Letters · doi:10.1016/j.toxlet.2004.04.011 · Cited by 7
Mosa, F. E. S., El‐Kadi, A. O. S., & Barakat, K. (2021) · IntechOpen eBooks · doi:10.5772/intechopen.99228 · Cited by 8
A prospective pilot study of the T‐lymphocyte response to fine particulate matter exposure
Zallouha, M. A., Landkocz, Y., Méausoone, C., Ledoux, F., Visade, F., Cazier, F., Martin, P. J., Borgie, M., Vitagliano, J., Trémolet, G., et al. (2020) · Journal of Applied Toxicology · doi:10.1002/jat.3932 · Cited by 5
Bergander, L. V. (2005) · KTH Publication Database DiVA (KTH Royal Institute of Technology) · Cited by 5
Korkalainen, M. (2005) · Työväentutkimus Vuosikirja · Cited by 5
Rowland, A. M., & Yost, G. S. (2010) · Elsevier eBooks · doi:10.1016/b978-0-08-046884-6.00926-x · Cited by 4
Cytochrome P450 Cyp2s1 regulation of the intestinal metabolome and microbiome
Dylgjeri, S., Bartoszek, E. M., Hruz, P. L., Melhem, H., & Niess, J. H. (2025) · Mucosal Immunology · doi:10.1016/j.mucimm.2025.10.007 · Cited by 3
Abdelhamid, G., Amara, I. E. A., Anwar‐Mohamed, A., & El‐Kadi, A. O. S. (2012) · Journal of Applied Toxicology · doi:10.1002/jat.2774 · Cited by 2
Ding, X., & Zhang, Q. (2010) · Elsevier eBooks · doi:10.1016/b978-0-08-046884-6.00402-4 · Cited by 2
Arzuaga, X. (2004) · UKnowledge (University of Kentucky) · Cited by 2
Variability in Induction of Human Drug Metabolizing Enzymes
Okey, A. B. (2005) · Drugs and the pharmaceutical sciences · doi:10.1201/9780849359507.ch6 · Cited by 2
Proteomic Characterization Reveals CYP2S1 as a Mediator of Drug Resistance in PDAC
Thiel, V., Nadler, W. M., Kerner, A., Kuhlmann, L., Reitberger, M., Vorberg, T., Schwerd‐Kleine, P., Noll, E. M., Giese, N. A., Yen, H.-Y., et al. (2025) · Pancreas · doi:10.1097/mpa.0000000000002553 · Cited by 1
Application of small interfering RNA technology in cytochrome P450 gene modulation
Jiang, W., Sang, R., Zhang, C., Yin, R., Ouyang, Z., & Yuan, W. (2025) · Drug Metabolism and Disposition · doi:10.1016/j.dmd.2025.100040 · Cited by 1
Shkrigunov, T., Vavilov, N. E., Samenkova, N. F., Kisrieva, Y. S., Rusanov, A. L., Romashin, D. D., Karuzina, I. I., Лисица, А. В., & Petushkova, N. A. (2024) · Biomeditsinskaya Khimiya · doi:10.18097/pbmc20247001061 · Cited by 1
Rowland, A. M., & Yost, G. S. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.64193-4 · Cited by 1
Novel extrahepatic P450 enzymes with emphasis on the tumor specific CYP2W1
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Extrahepatic cytochrome P450s - Relation to cancer susceptibility
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Characterization of proteins in the gonad of Limanda yokohamae from Masan Bay, Korea
Oh, J. H., Soo-Woon, K., Moon, H., Ok, G., & Choe, E. S. (2010) · Biologia · doi:10.2478/s11756-010-0068-9
Hu, S. (2005) · OhioLink ETD Center (Ohio Library and Information Network)
Biological and Toxicological responses to dioxins exposures
Malorni, L., Cozzolino, R., Boscaino, F., Castaldo, D., & Malorni, A. (2012)
Identifying Aryl Hydrocarbon Receptor Modulators from a Natural Source
Gendy, E. (2012) · ERA: Education and Research Archive (University of Alberta) · doi:10.7939/r3t40p
Modulation of Aryl Hydrocarbon Receptor Regulated-Genes by Mercury
Amara, I. E. A. (2013) · ERA: Education and Research Archive (University of Alberta) · doi:10.7939/r3zs2kq53
Elshenawy, O. H. (2017) · ERA: Education and Research Archive (University of Alberta) · doi:10.7939/r35h7c60g
Bioactivation of Xenobiotics in Lung: Role of CYPs and FMOs
Williams, D. E. (2008) · Springer eBooks · doi:10.1007/978-0-387-77300-1_13
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Fate of drug-metabolizing enzymes in cardiovascular diseases: Concepts and challenges
Shabbir, A., Niazi, S. G., Rehman, K., Akash, M. S. H., Kamran, S. H., & Khan, A. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-95120-3.00006-3
Haarmann‐Stemmann, T. (2007) · Univ. Duesseldorf: Duesseldorfer Dokumenten- und Publikationsserver
Wiles, M. C. (2004) · OakTrust (Texas A&M University Libraries)
Metadata
- Authors
- Rivera, S. P., Saarikoski, S. T., & Hankinson, O.
- Affiliations
- University of California, Los Angeles (US)
- Venue
- Molecular Pharmacology
- Publisher
- Elsevier BV
- Published
- 2002-02
- Volume
- 61
- Issue
- 2
- Pages
- 255-259
- ISSN
- 0026-895X (ISSN-L)
- OpenAlex
- W2166454597
- Cited by
- 149
- References
- 12
- Citations by year
- 2025: 3 · 2024: 3 · 2022: 4 · 2021: 4 · 2020: 3 · 2019: 4 · 2017: 5 · 2015: 5 · 2014: 3 · 2013: 5 · 2012: 6
- FWCI
- 12.50
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Cancer Institute (2 R01 CA28868-20, R01CA028868, R01 CA 28868)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Keywords
- CYP2S1, cytochrome P450, 2,3,7,8-tetrachlorodibenzo-p-dioxin, aryl hydrocarbon receptor, gene induction, lung epithelial cells, liver, representational difference analysis, cDNA cloning
- MeSH terms
- Amino Acid Sequence, Animals, Carcinogens, Cell Transformation, Neoplastic, Cytochrome P-450 Enzyme System, Dioxins, Enzyme Induction, Humans, Molecular Sequence Data, Oxygenases, RNA, Messenger, Transfection, Tumor Cells, Cultured, Gene Expression, Sequence Homology, Amino Acid, Mice
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