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Inhibitory effects of the ginsenoside Rg3 on phorbol ester-induced cyclooxygenase-2 expression, NF-κB activation and tumor promotion
Open accessAbstract
Our previous studies demonstrated the anti-oxidant and anti-tumor promotional properties of the methanol extract of heat-processed Panax ginseng C.A. Meyer [Cancer Lett. 150 (2000) 41]. In the present work, we have evaluated anti-inflammatory as well as anti-tumor promoting effects of Rg(3), a major ginsenoside derived from heat-processed ginseng. Pretreatment of dorsal skins of female ICR mice with Rg(3) significantly inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ornithine decarboxylase activity and 7,12-dimethylbenz[a]anthracene-initiated papilloma formation. In another experiment, Rg(3) pretreatment abrogated the expression of cyclooxygenase-2 in TPA-stimulated mouse skin. Rg(3) also inhibited the TPA-induced activation of the eukaryotic transcription factor, NF-kappaB in both mouse skin and cultured human pro-myelocytic leukemia (HL-60) cells. Moreover, Rg(3) exerted potent inhibitory effects on the activation of another transcription factor, activator protein-1 (AP-1) that is responsible for c-jun and c-fos oncogenic transactivation. Based on these findings, it is likely that the anti-tumor promoting activity of Rg(3) is mediated possibly through down-regulation of NF-kappaB and AP-1 transcription factors.
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Yamamoto, K., Arakawa, T., Ueda, N., & Yamamoto, S. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.52.31315 · Cited by 647
Dong, Z., Birrer, M. J., Watts, R. G., Matrisian, L. M., & Colburn, N. H. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.2.609 · Cited by 386
Yang, H.-S., Jansen, A. P., Nair, R., Shibahara, K., Verma, A. K., Cmarik, J. L., & Colburn, N. H. (2001) · Oncogene · doi:10.1038/sj.onc.1204137 · Cited by 185
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Shaito, A., Thuan, D. T. B., Phu, H. T., Nguyen, T. H. D., Hasan, H., Halabi, S., Abdelhady, S., Nasrallah, G. K., Eid, A. H., & Pintus, G. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00422 · Cited by 437
Xiang, Y., Shang, H., Gao, X., & Zhang, B. (2008) · Phytotherapy Research · doi:10.1002/ptr.2384 · Cited by 298
Metadata
- Authors
- Keum, Y.-S., Han, S. S., Chun, K.-S., Park, K.-K., Park, J.-H., Lee, S. K., & Surh, Y.-J.
- Venue
- Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
- Publisher
- Elsevier BV
- Published
- 2003-02
- Volume
- 523-524
- Pages
- 75-85
- ISSN
- 0027-5107 (ISSN-L)
- 1386-1964
- OpenAlex
- W2170781836
- Cited by
- 185
- References
- 3
- FWCI
- 3.86
- Type
- journal article
- Language
- en
- Open access
- green
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- Keum, Y.-S., Han, S. S., Chun, K.-S., Park, K.-K., Park, J.-H., Lee, S. K., & Surh, Y.-J. (2003). Inhibitory effects of the ginsenoside Rg3 on phorbol ester-induced cyclooxygenase-2 expression, NF-κB activation and tumor promotion. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. https://doi.org/10.1016/s0027-5107(02)00323-8
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