Transcriptional roles of nuclear factor κB and nuclear factor-interleukin-6 in the tumor necrosis factor α-dependent induction of cyclooxygenase-2 in MC3T3-E1 cells.

Yamamoto, Kei; Arakawa, Toshiya; Ueda, Natsuo; Yamamoto, Shozo

doi:10.1074/jbc.270.52.31315

Cited by 647Inflammatory mediators and NSAID effectsNF-κB Signaling PathwaysSignaling Pathways in Disease

Transcriptional roles of nuclear factor κB and nuclear factor-interleukin-6 in the tumor necrosis factor α-dependent induction of cyclooxygenase-2 in MC3T3-E1 cells.

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Yamamoto, Kei, Arakawa, Toshiya, Ueda, Natsuo, Yamamoto, Shozo·1995·Journal of Biological Chemistry

DOI 10.1074/jbc.270.52.31315

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Abstract

When a mouse osteoblastic cell line MC3T3-E1 was cultured in the presence of tumor necrosis factor alpha (TNF alpha), the release of prostaglandin E2 and the cyclooxygenase activity increased in a dose- and time-dependent manner. The increase of the enzyme activity was attributed mostly to the induction of cyclooxygenase-2 rather than cyclooxygenase-1 as judged by the inhibitory effect of NS398, Western blotting, and Northern blotting. In this system we attempted to elucidate the transcriptional regulation of the cyclooxygenase-2 gene. As examined by the luciferase assay, two positive regulatory regions (-186 to -131 and -512 to -385 base pairs) were found in the 5'-flanking promoter region of the mouse cyclooxygenase-2 gene in the TNF alpha-stimulated cells. The former included putative NF-IL6 (C/EBP beta) and AP2 elements, and the latter contained the NF kappa B motif. A DNA probe including the NF-IL6 and AP2 sites gave positive bands upon electrophoretic mobility shift assay using the nuclear extracts of MC3T3-E1 cells. The bands were supershifted by the addition of anti-NF-IL6 antibody but not by anti-AP2 antibody. A probe including the NF kappa B site also gave positive bands, which were supershifted by anti-NF kappa B p50 and p65 antibodies. Furthermore, when the motif of NF-IL6 or NF kappa B or both was subjected to point mutation, the luciferase activity was markedly reduced. These data suggested a potential role of both NF-IL6 and NF kappa B in the induction of cyclooxygenase-2 by TNF alpha.

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IL-6 is remarkably noninflammatory in tissues.
“One of the conundrums is that IL-6 is remarkably noninflammatory in tissues, and although there are some reports that IL-6 induces PGs in non-CNS cells, this seems to be uncommon and to occur at quite high concentrations (57) despite the presence of a nuclear factor IL-6 site upstream of the COX-2 gene (58).”
From Interleukin-6 is an afferent signal to the hypothalamo-pituitary-adrenal axis during local inflammation in mice (2003) · cites this paper as [58]

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PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT
Lowry, O. H., Rosebrough, N., Farr, A. L., & Randall, R. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52451-6 · Cited by 315,771 · see citing works
Multiple nuclear factors interact with the immunoglobulin enhancer sequences
Sen, R., & Baltimore, D. (1986) · Cell · doi:10.1016/0092-8674(86)90346-6 · Cited by 2,754 · see citing works
In vitro differentiation and calcification in a new clonal osteogenic cell line derived from newborn mouse calvaria.
Sudo, H., Kodama, H. A., Amagai, Y., Yamamoto, S., & Kasai, S. (1983) · The Journal of Cell Biology · doi:10.1083/jcb.96.1.191 · Cited by 1,673 · see citing works
NF-κB: A pleiotropic mediator of inducible and tissue-specific gene control
Lenardo, M. J., & Baltimore, D. (1989) · Cell · doi:10.1016/0092-8674(89)90833-7 · Cited by 1,611 · see citing works
A nuclear factor for IL‐6 expression (NF‐IL6) is a member of a C/EBP family.
Akira, S., Isshiki, H., Sugita, T., Tanabe, O., Kinoshita, S. M., Nishio, Y., Nakajima, T., Hirano, T., & Kishimoto, T. (1990) · The EMBO Journal · doi:10.1002/j.1460-2075.1990.tb08316.x · Cited by 1,446 · see citing works
The inducible transcription activator NF-κB: regulation by distinct protein subunits
Baeuerle, P. A. (1991) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/0304-419x(91)90007-8 · Cited by 1,036 · see citing works
Transcription factors NF-IL6 and NF-kappa B synergistically activate transcription of the inflammatory cytokines, interleukin 6 and interleukin 8.
Matsusaka, T., Fujikawa, K., Nishio, Y., Mukaida, N., Matsushima, K., Kishimoto, T., & Akira, S. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.21.10193 · Cited by 959 · see citing works
Compilation of vertebrate-encoded transcription factors
Faisst, S., & Meyer, S. (1992) · Nucleic Acids Research · doi:10.1093/nar/20.1.3 · Cited by 902 · see citing works
NS-398, a new anti-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitro
Futaki, N., Takahashi, S., Yokoyama, M., Arai, I., Higuchi, S., & Otomo, S. (1994) · Prostaglandins · doi:10.1016/0090-6980(94)90074-4 · Cited by 821 · see citing works
Functional dichotomy of neutral and acidic sphingomyelinases in tumor necrosis factor signaling
Wiegmann, K., Schütze, S., Machleidt, T., Witte, D., & Krönke, M. (1994) · Cell · doi:10.1016/0092-8674(94)90275-5 · Cited by 714 · see citing works
IL‐6 and NF‐IL6 in Acute‐Phase Response and Viral Infection
Akira, S., & Kishimoto, T. (1992) · Immunological Reviews · doi:10.1111/j.1600-065x.1992.tb01407.x · Cited by 531 · see citing works
Establishment of a clonal osteogenic cell line from newborn mouse calvaria
Kodama, H.-A., Amagai, Y., Sudo, H., Kasai, S., & Yamamoto, S. (1981) · Japanese Journal of Oral Biology · doi:10.2330/joralbiosci1965.23.899 · Cited by 506 · see citing works
Structure of the mitogen-inducible TIS10 gene and demonstration that the TIS10-encoded protein is a functional prostaglandin G/H synthase.
Fletcher, B. S., Kujubu, D. A., Perrin, D. M., & Herschman, H. R. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)42840-2 · Cited by 491 · see citing works
NF-κB and related proteins: Rel/dorsal homologies meet ankyrin-like repeats
Blank, V., Kourilsky, P., & Israël, A. (1992) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(92)90321-y · Cited by 399 · see citing works
Characterization of the human gene (PTGS2) encoding prostaglandin‐endoperoxide synthase 2
Kosaka, T., Miyata, A., Ihara, H., Hara, S., SUGIMOTO, T., Takeda, O., Takahashi, E., & Tanabe, T. (1994) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1994.tb18804.x · Cited by 383 · see citing works
Independent modes of transcriptional activation by the p50 and p65 subunits of NF-kappa B.Preprint
Fujita, T., Nolan, G. P., Ghosh, S., & Baltimore, D. (1992) · Genes & Development · doi:10.1101/gad.6.5.775 · Cited by 369 · see citing works
Regulation of prostaglandin synthase-1 and prostaglandin synthase-2
Herschman, H. R., & Hall, W. (1994) · Cancer and Metastasis Reviews · doi:10.1007/bf00666095 · Cited by 340 · see citing works
The p50 subunit of NF-kappa B associates with the NF-IL6 transcription factor.
LeClair, K. P., Blanar, M. A., & Sharp, P. A. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.17.8145 · Cited by 321 · see citing works
Constitutive and Interleukin-1 (IL-1)-Inducible Factors Interact with the IL-1-Responsive Element in the IL-6 Gene
Isshiki, H., Akira, S., Tanabe, O., Nakajima, T., Shimamoto, T., Hirano, T., & Kishimoto, T. (1990) · Molecular and Cellular Biology · doi:10.1128/mcb.10.6.2757 · Cited by 285 · see citing works
Transcriptional regulation of the rat prostaglandin endoperoxide synthase 2 gene in granulosa cells. Evidence for the role of a cis-acting C/EBP beta promoter element.
Sirois, J., & Richards, J. S. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)80630-9 · Cited by 233 · see citing works
[47] Oligonucleotide probes for the screening of recombinant DNA libraries
Wallace, R. B., & Miyada, C. G. (1987) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(87)52050-x · Cited by 214 · see citing works
v-src Induction of the TIS10/PGS2 Prostaglandin Synthase Gene Is Mediated by an ATF/CRE Transcription Response Element
Xie, W., Fletcher, B. S., Andersen, R. D., & Herschman, H. R. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.10.6531 · Cited by 205 · see citing works
The cyclic AMP response element plays an essential role in the expression of the human prostaglandin‐endoperoxide synthase 2 gene in differentiated U937 monocytic cells
Inoue, H., Nanayama, T., Hara, S., Yokoyama, C., & Tanabe, T. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)00731-4 · Cited by 186 · see citing works
Characterization and hormonal regulation of the promoter of the rat prostaglandin endoperoxide synthase 2 gene in granulosa cells. Identification of functional and protein-binding regions
Sirois, J., Levy, L. O., Simmons, D. L., & Richards, J. S. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)50326-x · Cited by 172 · see citing works
Differential regulation of inducible and constitutive prostaglandin endoperoxide synthase in osteoblastic MC3T3-E1 cells.
Pilbeam, C. C., Kawaguchi, H., Hakeda, Y., Voznesensky, O. S., Alander, C., & Raisz, L. G. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)74438-x · Cited by 171 · see citing works
Stimulation of prostaglandin E2 synthesis in cloned osteoblastic cells of mouse (MC3T3-E1) by epidermal growth factor.
Yokota, K., Kusaka, M., Ohshima, T., Yamamoto, S., Kurihara, N., Yoshino, T., & Kumegawa, M. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)66726-2 · Cited by 165 · see citing works
Proteins controlling the nuclear uptake of NF-κB, Rel and dorsal
Schmitz, M. L., Henkel, T., & Baeuerle, P. A. (1991) · Trends in Cell Biology · doi:10.1016/0962-8924(91)90118-s · Cited by 105 · see citing works
Tumor necrosis factor type α (cachectin) stimulates mouse osteoblast-like cells (MC3T3-E1) to produce macrophage-colony stimulating activity and prostaglandin E2
Sato, K., Kasono, K., Fujii, Y., Kawakami, M., Tsushima, T., & SHIZUME, K. (1987) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(87)91324-6 · Cited by 77 · see citing works
Induction of Cyclooxygenase-2 is Responsible for Interleukin-1 β-Dependent Prostaglandin E2 Synthesis by Human Lung Fibroblasts
Endo, T., Ogushi, F., Sone, S., Ogura, T., Taketani, Y., Hayashi, Y., Ueda, N., & Yamamoto, S. (1995) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.12.3.7873203 · Cited by 76 · see citing works
Studies on the induction of cyclooxygenase isozymes by various prostaglandins in mouse osteoblastic cell line with reference to signal transduction pathways
Takahashi, Y., Taketani, Y., Endo, T., Yamamoto, S., & Kumegawa, M. (1994) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(94)90256-9 · Cited by 62 · see citing works
cAMP-dependent induction of fatty acid cyclooxygenase mRNA in mouse osteoblastic cells (MC3T3-E1)
Oshima, T., Yoshimoto, T., Yamamoto, S., Kumegawa, M., Yokoyama, C., & Tanabe, T. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)92745-6 · Cited by 59 · see citing works
Possible induction of fatty acid cyclooxygenase in mouse osteoblastic cells (MC3T3-E1) by cAMP
Kusaka, M., Oshima, T., Yokota, K., Yamamoto, S., & Kumegawa, M. (1988) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/s0005-2728(88)80066-5 · Cited by 50 · see citing works
The transcriptional regulation of human arachidonate 12‐lipoxygenase gene by NFκB/Rel
Arakawa, T., Nakamura, M., Yoshimoto, T., & Yamamoto, S. (1995) · FEBS Letters · doi:10.1016/0014-5793(95)00293-i · Cited by 46 · see citing works
Signal transduction by tumor necrosis factor alpha is mediated through a guanine nucleotide-binding protein in osteoblast-like cell line, MC3T3-E1.
Yanaga, F., Abe, M., Koga, T., & Hirata, M. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)42738-x · Cited by 45 · see citing works
Fatty acid cyclooxygenase activity stimulated by transforming growth factor-β in mouse osteoblastic cells (MC3T3-E1)
Sumitani, K., Kawata, T., Yoshimoto, T., Yamamoto, S., & Kumegawa, M. (1989) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(89)90541-9 · Cited by 44 · see citing works
Molecular structure and function of the porcine arachidonate 12-lipoxygenase gene.
Arakawa, T., Oshima, T., Kishimoto, K., Yoshimoto, T., & Yamamoto, S. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)49822-0 · Cited by 33 · see citing works
Tumor necrosis factor-α stimulates phosphatidylinositol breakdown by phospholipase C to coordinately increase the levels of diacylglycerol, free arachidonic acid and prostaglandins in an osteoblast (MC3T3-E1) cell line
Rapuano, B. E., & Bockman, R. S. (1991) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/0167-4889(91)90203-a · Cited by 32 · see citing works
Section Review: Pulmonary-Allergy, Dermatological, Gastrointestinal & Arthritis: Differential interactions of prostaglandin endoperoxide synthases with nonsteroidal anti-inflammatory drugs
Smith, W. L., & DeWitt, D. L. (1994) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.3.1.1 · Cited by 19 · see citing works

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Research works printed but not linked: 2

Matsusaka, T., Fujikawa, K., Nishio, Y., Mukaida, N., Matsushima, K., Kishimoto, T., and Akira, S. (1993) Proc. Natl. Acad. Sci. U. S. A. 90, 10193-10197
LeClair, K. P., Blanar, M. A., and Sharp, P. A. (1992) Proc. Natl. Acad. Sci.

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Kiritoshi, S., Nishikawa, T., Sonoda, K., Kukidome, D., Senokuchi, T., Matsuo, T., Matsumura, T., Tokunaga, H., Brownlee, M., & Araki, E. (2003) · Diabetes · doi:10.2337/diabetes.52.10.2570 · Cited by 345 · see citing works
Transcriptional Activation of the Cyclooxygenase-2 Gene in Endotoxin-treated RAW 264.7 Macrophages
Wadleigh, D. J., Reddy, S. T., Kopp, E. B., Ghosh, S., & Herschman, H. R. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.9.6259 · Cited by 340 · see citing works
Role of pro-oxidants and antioxidants in the anti-inflammatory and apoptotic effects of curcumin (diferuloylmethane)
Sandur, S. K., Ichikawa, H., Pandey, M. K., Kunnumakkara, A. B., Sung, B., Sethi, G., & Aggarwal, B. B. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.05.009 · Cited by 331 · see citing works
Cyclo‐oxygenase‐2: pharmacology, physiology, biochemistry and relevance to NSAID therapy
Mitchell, J. A., & Warner, T. D. (1999) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0702897 · Cited by 324 · see citing works
“These pathways include, but are not limited to, reactive oxygen intermediates (Feng et al., 1995), NF-kB and NF-IL6 (Yamamoto et al., 1995), Ras/Rac1/ MEKK-1/JNK kinase/JNK signal transduction leading to phosphorylation of c-Jun (Xie & Herschman, 1996), ceramide (Hayakawa et al., 1996), mitogen-activated protein kinas…”
Background
Induction of Cyclooxygenase-2 and Activation of Nuclear Factor-κB in Myocardium of Patients With Congestive Heart Failure
Wong, S. C. Y., Fukuchi, M., Melnyk, P. M., Rodger, I. W., & Giaid, A. (1998) · Circulation · doi:10.1161/01.cir.98.2.100 · Cited by 323 · see citing works
Plumbagin (5-Hydroxy-2-methyl-1,4-naphthoquinone) Suppresses NF-κB Activation and NF-κB-regulated Gene Products Through Modulation of p65 and IκBα Kinase Activation, Leading to Potentiation of Apoptosis Induced by Cytokine and Chemotherapeutic Agents
Sandur, S. K., Ichikawa, H., Sethi, G., Ahn, K. S., & Aggarwal, B. B. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m601595200 · Cited by 322 · see citing works
Cyclooxygenase-2: a target for the prevention and treatment of breast cancer.
Howe, L. R., Subbaramaiah, K., Brown, A. M. C., & Dannenberg, A. J. (2001) · Endocrine Related Cancer · doi:10.1677/erc.0.0080097 · Cited by 322 · see citing works
Transcription factors and asthma
Barnes, P. J., & Adcock, I. M. (1998) · European Respiratory Journal · doi:10.1183/09031936.98.12010221 · Cited by 317 · see citing works
“NF-κB also regulates the expression of inflammatory enzymes, including the inducible form of nitric oxide synthase (iNOS) that produces large amounts of NO [36] and inducible cyclo-oxygenase (COX-2) that produces prostanoids [37, 38].”
Background
Targeting Nuclear Factor-κB Activation Pathway by Thymoquinone: Role in Suppression of Antiapoptotic Gene Products and Enhancement of Apoptosis
Sethi, G., Ahn, K. S., & Aggarwal, B. B. (2008) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-07-2088 · Cited by 316 · see citing works
Nonsteroidal anti-inflammatory agents differ in their ability to suppress NF-κB activation, inhibition of expression of cyclooxygenase-2 and cyclin D1, and abrogation of tumor cell proliferation
Takada, Y., Bhardwaj, A., Potdar, P. D., & Aggarwal, B. B. (2004) · Oncogene · doi:10.1038/sj.onc.1208169 · Cited by 310 · see citing works
“NSAIDs inhibit TNF-induced and NF-kB-regulated protein expression Through activation of NF-kB, TNF induces cyclin D1 and COX-2, both of which have NF-kB-binding sites in their promoters (Yamamoto et al., 1995; Guttridge et al., 1999; Hinz et al., 1999).”
Background
Lipopolysaccharide-Dependent Prostaglandin E2 Production Is Regulated by the Glutathione-Dependent Prostaglandin E2 Synthase Gene Induced by the Toll-Like Receptor 4/MyD88/NF-IL6 Pathway
Uematsu, S., Matsumoto, M., Takeda, K., & Akira, S. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.11.5811 · Cited by 308 · see citing works
The Spinal Phospholipase-Cyclooxygenase-Prostanoid Cascade in Nociceptive Processing
Svensson, C. I., & Yaksh, T. L. (2002) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.42.092401.143905 · Cited by 302 · see citing works
Suppression of inducible cyclooxygenase 2 gene transcription by aspirin and sodium salicylate
Xu, X.-M., Sansores-García, L., Chen, X.-M., Matijevic‐Aleksic, N., Du, M., & Wu, K. K. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.9.5292 · Cited by 301 · see citing works
Regulation of intracellular cyclooxygenase levels by gene transcription and protein degradation
Kang, Y.-J., Mbonye, U. R., DeLong, C. J., Wada, M., & Smith, W. L. (2007) · Progress in Lipid Research · doi:10.1016/j.plipres.2007.01.001 · Cited by 298 · see citing works
Physiological regulation of cyclooxygenase-2 in the kidney
Harris, R. C., & Breyer, M. D. (2001) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.2001.281.1.f1 · Cited by 297 · see citing works
Disease-modifying activity of SB 242235, a selective inhibitor of p38 mitogen-activated protein kinase, in rat adjuvant-induced arthritis
Badger, A. M., Griswold, D. E., Kapadia, R. D., Blake, S. M., Swift, B. A., Hoffman, S. J., Stroup, G. B., Webb, E. F., Rieman, D. J., Gowen, M., et al. (2000) · Arthritis & Rheumatism · doi:10.1002/1529-0131(200001)43:1 · Cited by 213 · see citing works
Targeting inflammation in metabolic syndrome
Welty, F. K., Alfaddagh, A., & Elajami, T. K. (2016) · Translational Research · doi:10.1016/j.trsl.2015.06.017 · Cited by 287 · see citing works
Expression from the human occludin promoter is affected by tumor necrosis factor α and interferon γ
Mankertz, J., Tavalali, S., Schmitz, H., Mankertz, A., Riecken, E. O., Fromm, M., & Schulzke, J. (2000) · Journal of Cell Science · doi:10.1242/jcs.113.11.2085 · Cited by 287 · see citing works
Spreading depression and focal brain ischemia induce cyclooxygenase-2 in cortical neurons through N -methyl- d -aspartic acid-receptors and phospholipase A 2
Miettinen, S., Fusco, F. R., Yrjänheikki, J., Keinänen, R., Hirvonen, T. J., Roivainen, R., Närhi, M. V. O., Hökfelt, T. G. M., & Koıstınaho, J. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.12.6500 · Cited by 276 · see citing works
Feedback control of cyclooxygenase-2 expression through PPARγ
Inoue, H., Tanabe, T., & Umesono, K. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001387200 · Cited by 276 · see citing works
The IKK/NF-kappa B pathway.
Senftleben, U., & Karin, M. (2002) · PubMed · Cited by 272 · see citing works
Induction of cyclooxygenase-2 by Epstein–Barr virus latent membrane protein 1 is involved in vascular endothelial growth factor production in nasopharyngeal carcinoma cells
Murono, S., Inoue, H., Tanabe, T., Joab, I., Yoshizaki, T., Furukawa, M., & Pagano, J. S. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.121016998 · Cited by 271 · see citing works
Resveratrol: Preventing properties against vascular alterations and ageing
Delmas, D., Jannin, B., & Latruffe, N. (2005) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200400098 · Cited by 269 · see citing works
Involvement of NF‐κB in the regulation of cyclooxygenase‐2 protein expression in LPS‐stimulated J774 macrophages
D’Acquisto, F., Iuvone, T., Rombolà, L., Sautebin, L., Rosa, M. D., & Carnuccio, R. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)01377-x · Cited by 269 · see citing works
Anacardic acid (6-nonadecyl salicylic acid), an inhibitor of histone acetyltransferase, suppresses expression of nuclear factor-κB–regulated gene products involved in cell survival, proliferation, invasion, and inflammation through inhibition of the inhibitory subunit of nuclear factor-κBα kinase, leading to potentiation of apoptosis
Sung, B., Pandey, M. K., Ahn, K. S., Yi, T., Chaturvedi, M. M., Liu, M., & Aggarwal, B. B. (2008) · Blood · doi:10.1182/blood-2007-10-117994 · Cited by 265 · see citing works
Neuroprotective Effect of Quercetin Against the Detrimental Effects of LPS in the Adult Mouse Brain
Khan, A., Ali, T., Rehman, S. U., Khan, M. S., Alam, S. I., Ikram, M. A., Muhammad, T., Saeed, K. M., Badshah, H., & Kim, M. O. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01383 · Cited by 262 · see citing works
“TNF-α, IL-1β and reactive species such NO and iNOS induced the overexpression of COX2, which has a key role in the intensification of neuroinflammation-mediated neurodegeneration (Feng et al., 1995; Yamamoto et al., 1995; O’Banion et al., 1996; Salvemini, 1997).”
Background
Guggulsterone Inhibits NF-κB and IκBα Kinase Activation, Suppresses Expression of Anti-apoptotic Gene Products, and Enhances Apoptosis
Shishodia, S., & Aggarwal, B. B. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m408093200 · Cited by 259 · see citing works
Discovery of a new function of cyclooxygenase (COX)-2: COX-2 is a cardioprotective protein that alleviates ischemia/reperfusion injury and mediates the late phase of preconditioning
Bolli, R. (2002) · Cardiovascular Research · doi:10.1016/s0008-6363(02)00414-5 · Cited by 258 · see citing works
Effects of Resveratrol in Inflammatory Arthritis
Elmali, N., Baysal, Ö., Harma, A., Esenkaya, İ., & Mızrak, B. (2006) · Inflammation · doi:10.1007/s10753-006-9012-0 · Cited by 251 · see citing works
Distribution of cyclooxygenase-1 and cyclooxygenase-2 mRNAs and proteins in human brain and peripheral organs
Yasojima, K., Schwab, C., McGeer, E. G., & McGeer, P. L. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01389-x · Cited by 250 · see citing works
Expression of mitogen-inducible cyclooxygenase induced by lipopolysaccharide
Hwang, D. H., Jang, B. C., Yu, G., & Boudreau, M. D. (1997) · Biochemical Pharmacology · doi:10.1016/s0006-2952(97)00154-8 · Cited by 248 · see citing works
Gambogic acid, a novel ligand for transferrin receptor, potentiates TNF-induced apoptosis through modulation of the nuclear factor-κB signaling pathway
Pandey, M. K., Sung, B., Ahn, K. S., Kunnumakkara, A. B., Chaturvedi, M. M., & Aggarwal, B. B. (2007) · Blood · doi:10.1182/blood-2007-03-079616 · Cited by 247 · see citing works
MiR-101 downregulation is involved in cyclooxygenase-2 overexpression in human colon cancer cells
Strillacci, A., Griffoni, C., Sansone, P., Paterini, P., Piazzi, G., Lazzarini, G., Spisni, E., Pantaleo, M. A., Biasco, G., & Tomasi, V. (2008) · Experimental Cell Research · doi:10.1016/j.yexcr.2008.12.010 · Cited by 243 · see citing works
The IKK/NF-κB pathway
Senftleben, U., & Karin, M. (2002) · Critical Care Medicine · doi:10.1097/00003246-200201001-00003 · Cited by 290 · see citing works
Transcriptional Regulation of Prostaglandin Synthase 2 Gene Expression by Platelet-derived Growth Factor and Serum
Xie, W., & Herschman, H. R. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.49.31742 · Cited by 239 · see citing works
Neuroprotective Strategies in Parkinson???s Disease
Mandel, S. A., Grünblatt, E., Riederer, P. F., Gerlach, M., Levites, Y., & Youdim, M. B. H. (2003) · CNS Drugs · doi:10.2165/00023210-200317100-00004 · Cited by 238 · see citing works
Differences in signaling pathways by IL-1β and IL-18
Lee, J.-K., Kim, S.-H., Lewis, E. C., Azam, T., Reznikov, L. L., & Dinarello, C. A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402800101 · Cited by 237 · see citing works
Identification of Direct Genomic Targets Downstream of the Nuclear Factor-κB Transcription Factor Mediating Tumor Necrosis Factor Signaling
Tian, B., Nowak, D. E., Jamaluddin, M., Wang, S., & Brasier, A. R. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m500437200 · Cited by 237 · see citing works
Inhibition of Nuclear Factor Kappa B (NF-B):: An Emerging Theme in Anti-Inflammatory Therapies
D’Acquisto, F. (2002) · Molecular Interventions · doi:10.1124/mi.2.1.22 · Cited by 237 · see citing works
15-epi-lipoxin A4–mediated Induction of Nitric Oxide Explains How Aspirin Inhibits Acute Inflammation
Paul‐Clark, M. J., Cao, T. V., Moradi‐Bidhendi, N., Cooper, D., & Gilroy, D. W. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20040566 · Cited by 236 · see citing works
Expression and Regulation of Cyclooxygenase‐2 in Rat Microglia
Bauer, M. K. A., Lieb, K., Schulze‐Osthoff, K., Berger, T., Gebicke‐Haerter, P. J., Bauer, J., & Fiebich, B. L. (1997) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1997.00726.x · Cited by 235 · see citing works
Vitamin E and immune response in the aged: molecular mechanisms and clinical implications
Meydani, S. N., Han, S. N., & Wu, D. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00274.x · Cited by 234 · see citing works
IL-6-regulated transcription factors
Akira, S. (1997) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(97)00063-0 · Cited by 231 · see citing works
NF-IL6 and NF-kappa B in cytokine gene regulation.
Akira, S., & Kishimoto, T. (1997) · PubMed · Cited by 231 · see citing works
miR‐301a as an NF‐κB activator in pancreatic cancer cells
Lu, Z., Li, Y., Takwi, A. A., Li, B., Zhang, J., Conklin, D. J., Young, K. H., Martin, R. C. G., & Li, Y. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.296 · Cited by 227 · see citing works
“We transfected PANC-1 cells with anti- miR-301a or an Nkrf overexpression construct and the Cox2 promoter upstream of a luc reporter (Yamamoto et al, 1995).”
Method
Withanolides potentiate apoptosis, inhibit invasion, and abolish osteoclastogenesis through suppression of nuclear factor-κB (NF-κB) activation and NF-κB–regulated gene expression
Ichikawa, H., Takada, Y., Shishodia, S., Bolleddula, J., Nair, M. G., & Aggarwal, B. B. (2006) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-06-0096 · Cited by 225 · see citing works
“4B), which is a NF-nB-regulated gene product (35, 36).”
Background
Cyclooxygenases and prostaglandins: shaping up the immune response
Rocca, B., & FitzGerald, G. A. (2002) · International Immunopharmacology · doi:10.1016/s1567-5769(01)00204-1 · Cited by 219 · see citing works
Resveratrol Suppresses Colitis and Colon Cancer Associated with Colitis
Cui, X., Yu, J. H., Hofseth, A. B., Peña, E. A., Habiger, J., Chumanevich, A. A., Poudyal, D., Nagarkatti, M., Nagarkatti, P. S., Singh, U. P., et al. (2010) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-09-0117 · Cited by 219 · see citing works
“For immunohistochemical staining, serial sections of mouse colon tissues (processed as described above) were incubated with antibodies against inducible nitric oxide synthase (iNOS; mouse monoclonal clone 5D5-H7; diluted 1:10,000; Research & Diagnostic Antibodies), cyclooxygenase-2 (COX-2; rabbit polyclonal; diluted 1…”
BackgroundInfluential
Acetyl-11-Keto-β-Boswellic Acid Potentiates Apoptosis, Inhibits Invasion, and Abolishes Osteoclastogenesis by Suppressing NF-κB and NF-κB-Regulated Gene Expression
Takada, Y., Ichikawa, H., Badmaev, V., & Aggarwal, B. B. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.5.3127 · Cited by 214 · see citing works
RETRACTED: Rosiglitazone, a ligand of the peroxisome proliferator-activated receptor-γ, reduces acute inflammation
Cuzzocrea, S., Pisano, B., Dugo, L., Ianaro, A., Maffia, P., Patel, N. S. A., Paola, R. D., Ialenti, A., Genovese, T., Chatterjee, P. K., et al. (2003) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2003.10.056 · Cited by 214 · see citing works
Retracted
Nuclear Factor-κB Regulates Cyclooxygenase-2 Expression and Cell Proliferation in Human Gastric Cancer Cells
Lim, J. W., Kim, H., & Kim, K. H. (2001) · Laboratory Investigation · doi:10.1038/labinvest.3780243 · Cited by 210 · see citing works
“The promoter region of the human COX-2 gene contains two NF-k B consensus sites, and the expression of COX-2 is largely regulated by NF-k B in several cells (Hla and Neilson, 1992; Yamamoto et al, 1995).”
An Essential Role of the Nuclear Factor of Activated T Cells in the Regulation of the Expression of the Cyclooxygenase-2 Gene in Human T Lymphocytes
Iñiguez, M. A., Martı́nez-Martı́nez, S., Punzón, C., Redondo, J. M., & Fresno, M. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001381200 · Cited by 205 · see citing works
Role of Mitogen-Activated Protein Kinase Cascades in Mediating Lipopolysaccharide-Stimulated Induction of Cyclooxygenase-2 and IL-1β in RAW264 Macrophages
Caivano, M., & Cohen, P. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.6.3018 · Cited by 204 · see citing works
“For example, NFkB is capable of activating a COX-2 promoter construct in IL-1 b-stimulated human pulmonary type II A549 cells (19), and mutation of the NF-kB response element partially inhibited TNFa-stimulated luciferase activity in transfected mouse osteoblastic MC3T3-E1 cells (20).”
Background
Repression of Cyclooxygenase-2 and Prostaglandin E2Release by Dexamethasone Occurs by Transcriptional and Post-transcriptional Mechanisms Involving Loss of Polyadenylated mRNA
Newton, R. C., Seybold, J., Kuitert, L. M. E., Bergmann, M., & Barnes, P. J. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.48.32312 · Cited by 197 · see citing works
NF-IL6 and NF-κB in Cytokine Gene Regulation
Akira, S., & Kishimoto, T. (1997) · Advances in immunology · doi:10.1016/s0065-2776(08)60740-3 · Cited by 201 · see citing works
NF-κB in cancer therapy
Li, F., Zhang, J., Arfuso, F., Chinnathambi, A., Zayed, M. E., Alharbi, S. A., Kumar, A. P., Ahn, K. S., & Sethi, G. (2015) · Archives of Toxicology · doi:10.1007/s00204-015-1470-4 · Cited by 198 · see citing works
“COX-2 has been also found to promote colon carcinoma-induced angiogenesis by producing important angiogenic factors (Tsujii et al. 1998).”
BackgroundInfluential
Prostaglandin E2 Regulates the Level and Stability of Cyclooxygenase-2 mRNA through Activation of p38 Mitogen-activated Protein Kinase in Interleukin-1β-treated Human Synovial Fibroblasts
Faour, W. H., He, Y., He, Q. W., de Ladurantaye, M., Quintero, M. V., Mancini, A. D., & Battista, J. A. D. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104036200 · Cited by 198 · see citing works
Transcriptional Regulation of Cyclooxygenase-2 in Mouse Skin Carcinoma Cells
Kim, Y., & Fischer, S. M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.42.27686 · Cited by 197 · see citing works
TNF-α-Induced Cyclooxygenase-2 Expression in Human Lung Epithelial Cells: Involvement of the Phospholipase C-γ2, Protein Kinase C-α, Tyrosine Kinase, NF-κB-Inducing Kinase, and I-κB Kinase 1/2 Pathway
Chen, C., Sun, Y.-T., Chen, J., & Chiu, K.-T. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.5.2719 · Cited by 197 · see citing works
“However, another transcriptional factor, NF-IL-6, might also be involved, as reported in MC3T3-E1 cells (12).”
Background
Zerumbone abolishes NF-κB and IκBα kinase activation leading to suppression of antiapoptotic and metastatic gene expression, upregulation of apoptosis, and downregulation of invasion
Takada, Y., Murakami, A., & Aggarwal, B. B. (2005) · Oncogene · doi:10.1038/sj.onc.1208845 · Cited by 196 · see citing works
“TNF has been shown to induce cyclin D1, c-Myc, COX-2, MMP-9, and ICAM-1, all of which have NF-kB binding sites in their promoters (Duyao et al., 1992; van de Stolpe et al., 1994; Yamamoto et al., 1995; Guttridge et al., 1999; Esteve et al., 2002).”
Background
Antioxidants modulate acute solar ultraviolet radiation-induced NF-kappa-B activation in a human keratinocyte cell line
Saliou, C., Kitazawa, M., McLaughlin, L., Yang, J., Lodge, J. K., Tetsuka, T., Iwasaki, K., Cillard, J., Okamoto, T., & Packer, L. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(98)00212-3 · Cited by 190 · see citing works
Butein, a Tetrahydroxychalcone, Inhibits Nuclear Factor (NF)-κB and NF-κB-regulated Gene Expression through Direct Inhibition of IκBα Kinase β on Cysteine 179 Residue
Pandey, M. K., Sandur, S. K., Sung, B., Sethi, G., Kunnumakkara, A. B., & Aggarwal, B. B. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m700890200 · Cited by 189 · see citing works
From chemoprevention to chemotherapy: common targets and common goals
Aggarwal, B. B., Takada, Y., & Oommen, O. V. (2004) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.13.10.1327 · Cited by 187 · see citing works
“NF-κB activation has been shown to regulate the expression of antiapoptotic proteins, such as B-cell leukaemia-2 (Bcl-2), long form of Bcl-x (Bcl-xL), survivin, TNF receptor-associated factor (TRAF)-1 and -2, cellular inhibitorof-apoptosis protein (cIAP), X-linked cIAP (XIAP) and cellular Fas-associated death domain p…”
Background
Cyclooxygenase (COX)-2 Inhibitor Celecoxib Abrogates TNF-Induced NF-κB Activation through Inhibition of Activation of IκBα Kinase and Akt in Human Non-Small Cell Lung Carcinoma: Correlation with Suppression of COX-2 Synthesis
Shishodia, S., Koul, D., & Aggarwal, B. B. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.3.2011 · Cited by 185 · see citing works
“Although celecoxib is known to inhibit the activity of COX-2, our results indicate that it can also suppress the synthesis of COX-2, which is regulated by NF- B (48).”
Background
Inhibitory effects of the ginsenoside Rg3 on phorbol ester-induced cyclooxygenase-2 expression, NF-κB activation and tumor promotion
Keum, Y., Han, S. S., Chun, K., Park, K.-K., Park, J.-H., Lee, S. K., & Surh, Y. (2003) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(02)00323-8 · Cited by 185 · see citing works
Transcriptional Role of the Nuclear Factor κB Site in the Induction by Lipopolysaccharide and Suppression by Dexamethasone of Cyclooxygenase-2 in U937 Cells
Inoue, H., & Tanabe, T. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.8222 · Cited by 185 · see citing works
Curcumin Modulates the Radiosensitivity of Colorectal Cancer Cells by Suppressing Constitutive and Inducible NF-κB Activity
Sandur, S. K., Deorukhkar, A., Pandey, M. K., Pabón, A. M., Shentu, S., Guha, S., Aggarwal, B. B., & Krishnan, S. (2009) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2009.06.034 · Cited by 183 · see citing works

TNF alpha-dependent induction of cyclooxygenase-2 mediated by NF kappa B and NF-IL6.
Yamamoto, K., Arakawa, T., Taketani, Y., Takahashi, Y., Hayashi, Y., Ueda, N., Yamamoto, S., & Kumegawa, M. (1997) · PubMed · Cited by 20 · see citing works
Transcriptional regulation of fatty acid cyclooxygenases-1 and -2.
Yamamoto, S., Yamamoto, K., Kurobe, H., Yamashita, R., Yamaguchi, H., & Ueda, N. (1998) · PubMed · Cited by 22 · see citing works
TNFα-Dependent Induction of Cyclooxygenase-2 Mediated by NFκB and NF-IL6
Yamamoto, K., Arakawa, T., Taketani, Y., Takahashi, Y., Hayashi, Y., Ueda, N., Yamamoto, S., & Kumegawa, M. (1997) · Advances in experimental medicine and biology · doi:10.1007/978-1-4899-1813-0_28 · Cited by 20 · see citing works
Tumor necrosis factor α (TNF-α)-induced prostaglanding E2 release is mediated by the activation of cyclooxygenase-2 (COX-2)transcription via NFκB in human gingival fibroblasts
Nakao, S., Ogtata, Y., Shimizu, E., Yamazaki, M., Furuyama, S., & Sugiya, H. (2002) · Molecular and Cellular Biochemistry · doi:10.1023/a:1019927616000 · Cited by 155 · see citing works
Involvement of TNF and NF-κB in the Transcriptional Control of Cyclooxygenase-2 Expression by IFN-γ in Macrophages
Sol, V. V., & Fresno, M. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.5.2825 · Cited by 77 · see citing works

Authors: Yamamoto, K., Arakawa, T., Ueda, N., & Yamamoto, S.
Affiliations: Tokushima University (JP)
Corresponding author: Yamamoto, Kei
Yamamoto, Shozo
ORCID: Yamamoto, Kei
Arakawa, Toshiya
Venue: Journal of Biological Chemistry
Publisher: Elsevier BV
Published: 1995-12
Volume: 270
Issue: 52
Pages: 31315-31320
ISSN: 0021-9258 (ISSN-L)
DOI: 10.1074/jbc.270.52.31315
OpenAlex: W2002708977
Cited by: 647
References: 38
Citations by year: 2026: 2 · 2025: 2 · 2024: 7 · 2023: 2 · 2022: 3 · 2021: 17 · 2020: 8 · 2019: 11 · 2018: 12 · 2017: 8 · 2016: 10 · 2015: 8 · 2014: 10 · 2013: 15 · 2012: 14
FWCI: 17.65
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 9116 d)
Locations: Journal of Biological Chemistry (publishedVersion, cc-by)
PubMed (publishedVersion)
Funders: Japan Foundation for Applied Enzymology
Japan Research Foundation for Clinical Pharmacology
Kissei
Ono Pharmaceutical
Japan Society for the Promotion of Science
Daiichi Sankyo Company
Topics: Health Sciences › Medicine › Pharmacology › Inflammatory mediators and NSAID effects
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
Keywords: cyclooxygenase-2, NF-κB, NF-IL6, C/EBPβ, TNF-α, transcriptional regulation, prostaglandin E2, MC3T3-E1 cells, osteoblasts, promoter regulation, gene induction
MeSH terms: Animals, Base Sequence, DNA-Binding Proteins, Enzyme Induction, Isoenzymes, Molecular Sequence Data, Nuclear Proteins, Oligodeoxyribonucleotides, Promoter Regions, Genetic, Prostaglandin-Endoperoxide Synthases, Regulatory Sequences, Nucleic Acid, Transcription, Genetic, Tumor Necrosis Factor-alpha, NF-kappa B, 3T3 Cells, CCAAT-Enhancer-Binding Proteins, Mice

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Transcriptional roles of nuclear factor κB and nuclear factor-interleukin-6 in the tumor necrosis factor α-dependent induction of cyclooxygenase-2 in MC3T3-E1 cells.

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