The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
DNA double-strand breaks, chromosomal rearrangements, and genomic instability
Abstract
DNA double-strand breaks can lead to chromosomal rearrangements at the first mitosis after exposure to the DNA strand-breaking agent. The evidence suggests a number of different pathways for DNA double-strand break rejoining in mammalian cells, but it is unclear what factors determine the fate of the induced break and whether or not it will lead to chromosomal rearrangement. If a cell does survive and proliferate after DNA cleavage, delayed chromosomal instability can be observed in the clonal descendants of the exposed cell. Most, but not all DNA double-strand breaking agents are effective at inducing this delayed chromosomal instability. In this paper, we review the evidence for the role of the DNA double-strand break in directly induced and delayed chromosomal rearrangements.
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“DNA breaks can be substrates for fusions and translocations of chromosomes (Morgan et al., 1998), which can accumulate in aging mice (Dolle and Vijg, 2002).”
From Aging mice have increased chromosome instability that is exacerbated by elevated Mdm2 expression (2011) · cites this paper as Morgan et al., 1998
Citations
Cites
Genomic Instability Induced by Ionizing Radiation
Morgan, W. F., Day, J. P., Kaplan, M. I., McGhee, E. M., & Limoli, C. L. (1996) · Radiation Research · doi:10.2307/3579454 · Cited by 480
Self-citationThe role of DNA double strand breaks in lonizing radiation‐induced killing of eukaryotic cells
Lliakis, G. (1991) · BioEssays · doi:10.1002/bies.950131204 · Cited by 329
Delayed Chromosomal Instability Induced by DNA Damage
Marder, B. A., & Morgan, W. F. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.11.6667-6677.1993 · Cited by 273
Self-citationNatarajan, A. T., Obe, G., van Zeeland, A. A., Palitti, F., Meijers, M., & Verdegaal-Immerzeel, E. A. M. (1980) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/0027-5107(80)90094-9 · Cited by 270
Delayed chromosomal instability induced by DNA damage.
Marder, B. A., & Morgan, W. F. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.11.6667 · Cited by 204
Self-citationObe, G., Johannes, C., & Schulte‐Frohlinde, D. (1992) · Mutagenesis · doi:10.1093/mutage/7.1.3 · Cited by 165
Chromosomal Aberrations: Basic and Applied Aspects
Obe, G., & Natarajan, A. T. (2011) · Cited by 119
Differential induction of chromosomal instability by DNA strand-breaking agents.
Limoli, C. L., Kaplan, M. I., Phillips, J. W., Adair, G. M., & Morgan, W. F. (1997) · PubMed · Cited by 118
Self-citationIllegitimate recombination induced by DNA double-strand breaks in a mammalian chromosome.
Phillips, J. W., & Morgan, W. F. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.9.5794 · Cited by 117
Self-citationBryant, P. E. (1988) · International Journal of Radiation Biology · doi:10.1080/09553008814552291 · Cited by 110
Chang, W. P., & Little, J. B. (1992) · Radiation Research · doi:10.2307/3578316 · Cited by 74
Illegitimate Recombination Induced by DNA Double-Strand Breaks in a Mammalian Chromosome
Phillips, J. W., & Morgan, W. F. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.9.5794-5803.1994 · Cited by 49
Self-citationWang, P., Zhou, R.-H., Zou, Y. S., Jackson‐Cook, C. K., & Povirk, L. F. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.22.12018 · Cited by 40
Ager, D. D., Phillips, J. W., Columna, E. A., Winegar, R. A., & Morgan, W. F. (1991) · Radiation Research · doi:10.2307/3578132 · Cited by 31
Self-citationThe Use of Restriction Endonucleases to Study the Mechanisms of Chromosome Damage
Morgan, W. F., & Winegar, R. A. (1990) · Springer eBooks · doi:10.1007/978-3-642-75682-5_8 · Cited by 30
Self-citationXiao, Z. J., Miller, G. G., McCallum, T. J., Brown, K. M., Lown, J. W., TULIP, J., & Moore, R. B. (1998) · Photochemistry and Photobiology · doi:10.1562/0031-8655(1998)067 · Cited by 30
The Nucleus Is the Target for Radiation-Induced Chromosomal Instability
Kaplan, M. I., & Morgan, W. F. (1998) · Radiation Research · doi:10.2307/3579656 · Cited by 29
Self-citationInduction of Chromosome Aberrations and Delayed Genomic Instability by Photochemical Processes
Limoli, C. L., Day, J. P., Ward, J. F., & Morgan, W. F. (1998) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1998.tb05192.x · Cited by 16
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Morgan, W. F. (2003) · Radiation Research · doi:10.1667/0033-7587(2003)159[0567:nadeoe]2.0.co;2 · Cited by 651
Self-citationAndrogen-induced TOP2B-mediated double-strand breaks and prostate cancer gene rearrangements
Haffner, M. C., Aryee, M. J., Toubaji, A., Esopi, D., Albadine, R., Gürel, B., Isaacs, W. B., Bova, G. S., Liu, W., Xu, J., et al. (2010) · Nature Genetics · doi:10.1038/ng.613 · Cited by 624
Role of plant polyphenols in genomic stability
Ferguson, L. R. (2001) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(01)00073-2 · Cited by 591
Seril, D. N. (2003) · Carcinogenesis · doi:10.1093/carcin/24.3.353 · Cited by 467
The role of DNA damage and repair in aging through the prism of Koch-like criteria
Moskalev, A. A., Shaposhnikov, M. V., Plyusnina, E. N., Zhavoronkov, A., Budovsky, A., Yanai, H., & Fraifeld, V. E. (2013) · Ageing Research Reviews · doi:10.1016/j.arr.2012.02.001 · Cited by 387
Metadata
- Authors
- Morgan, W. F., Corcoran, J., Hartmann, A., Kaplan, M. I., Limoli, C. L., & Ponnaiya, B.
- Affiliations
- University of California, San Francisco (US)
- Lawrence Berkeley National Laboratory (US)
- Corresponding author
- Morgan, William F.
- ORCID
- Limoli, Charles L.
- Venue
- Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
- Publisher
- Elsevier BV
- Published
- 1998-08
- Volume
- 404
- Issue
- 1-2
- Pages
- 125-128
- ISSN
- 0027-5107 (ISSN-L)
- 1386-1964
- OpenAlex
- W1971729092
- Cited by
- 105
- References
- 15
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 5 · 2021: 3 · 2020: 5 · 2019: 4 · 2018: 1 · 2017: 2 · 2016: 5 · 2015: 4 · 2014: 3 · 2013: 5 · 2012: 2
- FWCI
- 0.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Mutation research. Fundamental and molecular mechanisms of mutagenesis (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5-T32-ES07016)
- Office of Naval Research
- U.S. Department of Energy (DE-4459-011542)
- National Institute of Environmental Health Sciences
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genomic variations and chromosomal abnormalities
- Keywords
- DNA double-strand breaks, chromosomal rearrangements, genomic instability, DNA double-strand break rejoining, mitotic recombination, clonal cell lines, mammalian cells
- MeSH terms
- Animals, Chromosome Aberrations, DNA, DNA Damage, DNA Repair, DNA Restriction Enzymes, Cricetinae, Mammals, CHO Cells, Chromosome Breakage
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