The DOI matches its Crossref record.
Placental apoptosis in preeclampsia
Abstract
OBJECTIVE: To determine whether preeclampsia is associated with an increase in placental apoptosis and differential expression of mediators of apoptosis. METHODS: Placental samples from 31 preeclamptic women and 31 normotensive controls were analyzed using terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labeling staining. Expression of Fas, Fas ligand, Bcl-2, and Bax was assessed using immunohistochemistry. RESULTS: The median percent apoptotic nuclei was significantly higher for the study group than for the controls (0.49 versus 0.19; P =.001), as was the median percent apoptotic nuclei in the trophoblast nuclei (0.33 versus 0.09; P <.01). Fas ligand expression was significantly less and Fas expression significantly greater in the villus trophoblast among the study subjects compared with controls. There was no difference in the expression of Bax or Bcl-2 between groups. CONCLUSION: Placental apoptosis and altered expression of Fas and Fas ligand in trophoblast might influence pathogenesis or sequelae of preeclampsia.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Roberts, J. M., & Gammill, H. S. (2005) · Hypertension · doi:10.1161/01.hyp.0000188408.49896.c5 · Cited by 693
Burton, G. J., Yung, H.-W., Cindrova-Davies, T., & Charnock-Jones, D. S. (2009) · Placenta · doi:10.1016/j.placenta.2008.11.003 · Cited by 502
Apoptosis in the Trophoblast—Role of Apoptosis in Placental Morphogenesis
Huppertz, B., & Kingdom, J. C. P. (2004) · Journal of the Society for Gynecologic Investigation · doi:10.1016/j.jsgi.2004.06.002 · Cited by 262
Formation of Syncytial Knots is Increased by Hyperoxia, Hypoxia and Reactive Oxygen Species
Heazell, A. E. P., Moll, S. J., Jones, C. J. P., Baker, P. N., & Crocker, I. P. (2007) · Placenta · doi:10.1016/j.placenta.2006.10.007 · Cited by 204
Differential Regulation and Function of the Fas/Fas Ligand System in Human Trophoblast Cells1
Aschkenazi, S., Straszewski, S., Verwer, K. M. A., Foellmer, H., Rutherford, T., & Mor, G. (2002) · Biology of Reproduction · doi:10.1095/biolreprod66.6.1853 · Cited by 161
Metadata
- Authors
- Allaire, A.
- Venue
- Obstetrics & Gynecology
- Published
- 2000-08
- Volume
- 96
- Issue
- 2
- Pages
- 271-276
- ISSN
- 0029-7844 (ISSN-L)
- OpenAlex
- W2028397040
- Cited by
- 434
- References
- 0
- FWCI
- 18.63
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Placental apoptosis in preeclampsia. https://app.cochat.ai/papers/10.1016/s0029-7844(00)00895-4
- The paper
- Allaire, A. (2000). Placental apoptosis in preeclampsia. Obstetrics & Gynecology. https://doi.org/10.1016/s0029-7844(00)00895-4
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
