Preeclampsia: Recent Insights
Abstract
Preeclampsia is a pregnancy complication with serious consequences for mother and infant. The disorder is diagnosed by gestational hypertension and proteinuria but is far more than pregnancy induced hypertension. Preeclampsia is proposed to occur in 2 stages. Stage 1 reduced placental perfusion is postulated as the root cause and to lead to the maternal syndrome, Stage 2. Why perfusion is reduced, how this translates to a maternal disease in some but not all women and what is the linkage of the 2 stages are topics of intense study. In the last decade such studies have provided valuable insights into pathophysiology that now guide ongoing clinical trials.
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Pre-eclampsia is caused by the development of arterial dysfunction in the placenta, which involves oxidative injury and an inflammatory response spreading beyond the placenta to impact upon all major organs in the mother.
“PE is caused by the development of arterial dysfunction in the placenta, which involves oxidative injury and an inflammatory response spreading beyond the placenta to impact upon all major organs in the mother. 64”
From Overweight, obesity and excessive weight gain in pregnancy as risk factors for adverse pregnancy outcomes: A narrative review (2022) · cites this paper as [64]
Cites
Circulating angiogenic factors and the risk of preeclampsia
Levine, R. J., Maynard, S. E., Qian, C., Lim, K.-H., England, L. J., Yu, K. F., Schisterman, E. F., Thadhani, R., Sachs, B. P., Epstein, F. H., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa031884 · Cited by 3,720 · see citing works
Risk factors for pre‐eclampsia in nulliparous and parous women: the Jerusalem Perinatal Study
Funai, E. F., Paltiel, O. B., Malaspina, D., Friedlander, Y., Deutsch, L., & Harlap, S. (2005) · Paediatric and Perinatal Epidemiology · doi:10.1111/j.1365-3016.2004.00623.x · Cited by 135 · see citing works
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Pre-eclampsia part 1: current understanding of its pathophysiology
Chaiworapongsa, T., Chaemsaithong, P., Yeo, L., & Romero, R. (2014) · Nature Reviews Nephrology · doi:10.1038/nrneph.2014.102 · Cited by 956 · see citing works
Kell, D. B. (2009) · BMC Medical Genomics · doi:10.1186/1755-8794-2-2 · Cited by 554 · see citing works
Langley‐Evans, S. C., Pearce, J., & Ellis, S. (2022) · Journal of Human Nutrition and Dietetics · doi:10.1111/jhn.12999 · Cited by 288 · see citing works
Tosun, M., Celik, H., Avci, B., Yavuz, E., Alper, T., & Malatyalioğlu, E. (2010) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.3109/14767051003774942 · Cited by 185 · see citing works
Recent Progress Toward the Understanding of the Pathophysiology of Hypertension During Preeclampsia
LaMarca, B. D., Gilbert, J., & Granger, J. P. (2008) · Hypertension · doi:10.1161/hypertensionaha.107.108837 · Cited by 142 · see citing works
Hypertensive Disorders of Pregnancy and Offspring Cardiac Structure and Function in Adolescence
Timpka, S., Macdonald‐Wallis, C., Hughes, A. D., Chaturvedi, N., Franks, P. W., Lawlor, D. A., & Fraser, A. (2016) · Journal of the American Heart Association · doi:10.1161/jaha.116.003906 · Cited by 106 · see citing works
Preeclampsia and Risk for Epilepsy in Offspring
Wu, C. S., Sun, Y., Vestergaard, M., Christensen, J., Ness, R. B., Haggerty, C. L., & Olsen, J. (2008) · Pediatrics · doi:10.1542/peds.2007-3666 · Cited by 77 · see citing works
Trace elements and oxidative stress in hypertensive disorders of pregnancy
Fenzl, V., Flegar-Meštrić, Z., Perkov, S., Andrišić, L., Tatzber, F., Žarković, N., & Duić, Ž. (2013) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-012-2502-4 · Cited by 61 · see citing works
A review of inter- and intraspecific variation in the eutherian placenta
Gundling, W. E., & Wildman, D. E. (2015) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2014.0072 · Cited by 58 · see citing works
Yang, J., Pearl, M., DeLorenze, G. N., Romero, R., Dong, Z., Jelliffe-Pawlowski, L., Currier, R., Flessel, M., & Kharrazi, M. (2016) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2016.04.002 · Cited by 37 · see citing works
- Authors
- Roberts, J. M., & Gammill, H. S.
- Affiliations
- University of Pittsburgh (US)
- ORCID
- Roberts, James M.
- Venue
- Hypertension
- Published
- 2005-12
- Volume
- 46
- Issue
- 6
- Pages
- 1243-1249
- ISSN
- 0194-911X (ISSN-L)
- 1524-4563
- OpenAlex
- W2116806083
- Cited by
- 693
- References
- 2
- Citations by year
- 2026: 14 · 2025: 22 · 2024: 24 · 2023: 23 · 2022: 24 · 2021: 41 · 2020: 34 · 2019: 28 · 2018: 21 · 2017: 34 · 2016: 33 · 2015: 31 · 2014: 51 · 2013: 39 · 2012: 50
- FWCI
- 5.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Hypertension (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD30367, P01HD030367)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Health Sciences › Medicine › Psychiatry and Mental health › Neurological Complications and Syndromes
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Keywords
- preeclampsia, gestational hypertension, proteinuria, placental perfusion, pathophysiology, pregnancy complications, clinical trials
- MeSH terms
- Endocrinology, Female, Humans, Maternal-Fetal Exchange, Placenta, Pre-Eclampsia, Pregnancy, Regional Blood Flow
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