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Elevated homocyst(e)ine levels with preeclampsia
Abstract
OBJECTIVE: To determine whether homocyst(e)ine, a relatively new risk factor for possible endothelial cell dysfunction and premature vascular disease, is elevated in nulliparous pregnant women with preeclampsia. METHODS: We measured plasma homocyst(e)ine, folic acid, and vitamin B12 levels in 40 nulliparas, 20 with and 20 without preeclampsia at the time of their delivery. RESULTS: Mean (+/- standard deviation) plasma homocyst(e)ine levels in the 20 nulliparous women with preeclampsia were significantly higher than in the 20 nulliparous women without preeclampsia (8.66 +/- 3.05 versus 4.99 +/- 1.11 mumol/L, P < .001). Folic acid and vitamin B12 concentrations were not significantly different between the two groups. CONCLUSION: Homocyst(e)ine levels are elevated in pregnant nulliparas with preeclampsia at the time of their delivery. Further studies are necessary to determine what role homocyst(e)ine may play in the etiology of preeclampsia.
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Cited by
Folic Acid: Nutritional Biochemistry, Molecular Biology, and Role in Disease Processes
Lucock, M. (2000) · Molecular Genetics and Metabolism · doi:10.1006/mgme.2000.3027 · Cited by 815
Ray, J. G., & Laskin, C. A. (1999) · Placenta · doi:10.1053/plac.1999.0417 · Cited by 401
Tamura, T., & Picciano, M. F. (2006) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/83.5.993 · Cited by 379
Ultraviolet photodegradation of folic acid
Off, M. K., Steindal, A. E., Porojnicu, A. C., Juzeniene, A., Vorobey, A., Johnsson, A., & Moan, J. (2005) · Journal of Photochemistry and Photobiology B: Biology · doi:10.1016/j.jphotobiol.2005.03.001 · Cited by 235
A critical role for B-vitamin nutrition in human developmental and evolutionary biology
Lucock, M., Yates, Z., Glanville, T., Leeming, R., Simpson, N., & Daskalakis, I. (2003) · Nutrition Research · doi:10.1016/s0271-5317(03)00156-8 · Cited by 47
Metadata
- Authors
- RAJKOVIC, A., CATALANO, P., & MALINOW, M.
- Venue
- Obstetrics & Gynecology
- Published
- 1997-08
- Volume
- 90
- Issue
- 2
- Pages
- 168-171
- ISSN
- 0029-7844 (ISSN-L)
- OpenAlex
- W2060639189
- Cited by
- 174
- References
- 0
- FWCI
- 16.22
- Type
- journal article
- Language
- en
- Open access
- closed
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- RAJKOVIC, A., CATALANO, P., & MALINOW, M. (1997). Elevated homocyst(e)ine levels with preeclampsia. Obstetrics & Gynecology. https://doi.org/10.1016/s0029-7844(97)00223-8
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