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Folate and human reproduction

Tamura, Tsunenobu, Picciano, Mary Frances·2006·The American Journal of Clinical Nutrition
DOI 10.1093/ajcn/83.5.993
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Abstract

The influence of folate nutritional status on various pregnancy outcomes has long been recognized. Studies conducted in the 1950s and 1960s led to the recognition of prenatal folic acid supplementation as a means to prevent pregnancy-induced megaloblastic anemia. In the 1990s, the utility of periconceptional folic acid supplementation and folic acid food fortification emerged when they were proven to prevent the occurrence of neural tube defects. These distinctively different uses of folic acid may well be ranked among the most significant public health measures for the prevention of pregnancy-related disorders. Folate is now viewed not only as a nutrient needed to prevent megaloblastic anemia in pregnancy but also as a vitamin essential for reproductive health. This review focuses on the relation between various outcomes of human reproduction (ie, pregnancy, lactation, and male reproduction) and folate nutrition and metabolism, homocysteine metabolism, and polymorphisms of genes that encode folate-related enzymes or proteins, and we identify issues for future research.

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  • Congenital malformations induced by inadequate folate are believed to have been instrumental in the natural selection of dark skin at low latitudes to protect folate for reproductive success and maintenance of fertility.

    “congenital malformations induced by inadequate folate are also believed to have been instrumental in the natural selection of dark skin at low latitudes to protect folate for reproductive success and the maintenance of fertility”

    From The evolution of human skin pigmentation: A changing medley of vitamins, genetic variability, and UV radiation during human expansion (2023) · cites this paper as Tamura & Picciano, 2006

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Metadata

Authors
Tamura, T., & Picciano, M. F.
Venue
The American Journal of Clinical Nutrition
Publisher
Elsevier BV
Published
2006-05
Volume
83
Issue
5
Pages
993-1016
ISSN
0002-9165
DOI
10.1093/ajcn/83.5.993
Cited by
379
References
1
Language
en
Licence

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